Giant Primary Schwannoma of the Left Nasal Cavity and Ethmoid Sinus

Wong, Eugene; Kong, Justin; Oh, Lawrence; Cox, Daniel; Forer, Martin

doi:10.1155/2016/1706915

Cited by 9 publications

(10 citation statements)

References 5 publications

(5 reference statements)

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“…Mitra B et al [2] , Vaidya MM et al [3] , Dhawle MS et al [4] and Mangubat EZ et al [6] documented schwannoma in male patient. On the contrary, Singh M et al [5] , Mosalleum EMA [7] and Wong E et al [8] reported the lesion in female patients in their case reports.…”

Section: Discussionmentioning

confidence: 92%

“…Wong E et al [8] reported a case of sinonasal schwannoma in sixth decade in their case report. Mitra B et al [2] , Vaidya MM et al [3] , Dhawle MS et al [4] and Mangubat EZ et al [6] documented schwannoma in male patient.…”

Section: Discussionmentioning

confidence: 99%

“…Mangubat EZ et al [6] described a case of schwannoma presenting as right frontal sinus lesion. Wong E et al [8] reported a case of giant primary schannoma involving left nasal cavity and ethmoidal sinus. In contrast, Mosalleum EMA [7] et al documented the neoplasm involving left nasal vestibule without any involvement of paranasal sinues.…”

Section: Discussionmentioning

confidence: 99%

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Right Ethmoidal Sinus Schwannoma: Case Report of a Common Entity with an Unusual Presentation

Kavitha

Swapna

Kumarguru

et al. 2020

Ann of Pathol and Lab Med

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Schwannomas are benign, encapsulated nerve sheath tumors arising from Schwann cells. Approximately, 25-40% of all Schwannomas occur in the head and neck region, acoustic nerve being the most frequent site. The tumors originating from nasal cavity or paranasal sinuses are rare and constitutes only four percent. A 40-year-old male presented with history of blurred vision of right eye and protrusion of right eye ball since 6 months. It was associated with history of watering and redness. Examination of right eye revealed mild proptosis and ptosis. Computed Tomography [CT] scan showed a large expansile cystic lesion measuring about 5.2x5.6x6.5cm involving entire right ethmoidal sinus. It showed expansion into anterior cranial fossa, roof and medial wall of right orbit. Radiological opinion suggested mucocele of right ethmoidal sinus. Intra-operatively, tissue specimen was sent for squash smear cytology. Cytology smears showed features suggestive of spindle cell tumor. Possibility of Schwannoma was considered. The specimen was subsequently subjected to histopathological examination. Microscopy showed tumor tissue composed of tumor cells arranged in alternate hypercellular and hypocellular pattern. Hypercellular areas showed occasional verocay bodies. Hypocellular areas showed loosely arranged spindle shaped tumor cells. Histopathological features were suggestive of Schwannoma. On Immunohistochemistry (IHC), neoplastic cells were positive for S-100 and negative for EMA. Ethmoidal sinus schwannoma extending into anterior cranial fossa is an unusual presentation. Clinically, it poses a diagnostic dilemma. Squash smear cytology is challenging, but helpful in establishing the correct diagnosis. Histopathology is confirmatory and immunohistochemistry is supportive.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Right Ethmoidal Sinus Schwannoma: Case Report of a Common Entity with an Unusual Presentation

Kavitha

Swapna

Kumarguru

et al. 2020

Ann of Pathol and Lab Med

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“…Preoperative biopsy is considered to diagnose these type of cases but excisional biopsy can also be done based upon clinical and radiological assessment [10]. Schwannomas appear as gelatinous, cystic, well circumscribed encapsulated masses and are usually amenable for endoscopic removal [11]. On histopathological examination, schwannomas exhibit Antoni A and Antoni B patterns.…”

Section: Discussionmentioning

confidence: 99%

An Extensive Unilateral Nasal Mass: Septal Schwannoma—Case Report

Roy

Patel

Gahlot

2021

Indian J Otolaryngol Head Neck Surg

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Schwannomas are benign peripheral nerve sheath tumours that arise from the Schwann cells of the myelinated nerve and may occur throughout the body. Paranasal schwannomas are uncommon lesions, representing less than 4% of all head and neck schwannomas and nasal septal schwannomas are very rare. Here we report a rare case of sinonasal schwannoma in a 46-yearold male who presented with a history of progressive nasal blockage of 3 years duration. The mass was removed by endoscopic approach without any postoperative complication. The rarity of diagnosis was aided by immune histopathology (IHC) of the tissue to confirm the disease.

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“…In particular, it is difficult to distinguish between OEC tumors and schwannomas, since both tumors arise from glial cells with a shared developmental origin (the neural crest, [51]), as well as many similar morphological and molecular characteristics (reviewed in [6]). The schwannomas that are so easily confused with OEC tumors are usually termed anterior cranial fossa schwannomas or olfactory groove schwannomas (OGS) but can also occasionally be found in the nasal cavity and paranasal sinuses (nasoethmoid schwannomas) [71][72][73][74][75]. These schwannomas are rare; to date, approximately 45 cases (without neurofibromatosis/schwannomatosis) have been reported in the literature [76,77].…”

Section: Why Is It Difficult To Distinguish Between Oec Tumors and Scmentioning

confidence: 99%

Why are olfactory ensheathing cell tumors so rare?

et al. 2019

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The glial cells of the primary olfactory nervous system, olfactory ensheathing cells (OECs), are unusual in that they rarely form tumors. Only 11 cases, all of which were benign, have been reported to date. In fact, the existence of OEC tumors has been debated as the tumors closely resemble schwannomas (Schwann cell tumors), and there is no definite method for distinguishing the two tumor types. OEC transplantation is a promising therapeutic approach for nervous system injuries, and the fact that OECs are not prone to tumorigenesis is therefore vital. However, why OECs are so resistant to neoplastic transformation remains unknown. The primary olfactory nervous system is a highly dynamic region which continuously undergoes regeneration and neurogenesis throughout life. OECs have key roles in this process, providing structural and neurotrophic support as well as phagocytosing the axonal debris resulting from turnover of neurons. The olfactory mucosa and underlying tissue is also frequently exposed to infectious agents, and OECs have key innate immune roles preventing microbes from invading the central nervous system. It is possible that the unique biological functions of OECs, as well as the dynamic nature of the primary olfactory nervous system, relate to the low incidence of OEC tumors. Here, we summarize the known case reports of OEC tumors, discuss the difficulties of correctly diagnosing them, and examine the possible reasons for their rare incidence. Understanding why OECs rarely form tumors may open avenues for new strategies to combat tumorigenesis in other regions of the nervous system.

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Giant Primary Schwannoma of the Left Nasal Cavity and Ethmoid Sinus

Cited by 9 publications

References 5 publications

Right Ethmoidal Sinus Schwannoma: Case Report of a Common Entity with an Unusual Presentation

Right Ethmoidal Sinus Schwannoma: Case Report of a Common Entity with an Unusual Presentation

An Extensive Unilateral Nasal Mass: Septal Schwannoma—Case Report

Why are olfactory ensheathing cell tumors so rare?

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