Giant posterior fossa tuberculoma in immunocompetent adults

Bouali, Sofiene; Bahri, K.; Zehani, Alia; Ghedira, Khalil; Abderrahmen, Khansa; Kallel, Jalel

doi:10.1016/j.ehpc.2019.200342

Cited by 6 publications

(17 citation statements)

References 11 publications

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“…Most literature have described adult intracranial tuberculomas to be commonly seen in the supratentorial location of the frontal and the parietal lobes however few cases in children have shown involvement in the infratentorial region [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Caseating solid tuberculomas appear hypo-intense on T1WI and T2WI which is thought to be due to granulation tissue and compressed glial tissue in the central core resulting in greater cellular density than the brain parenchyma. On post gadolinium, these also demonstrate rim enhancement [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…The recommended drugs are Isoniazid, rifampin, pyrazinamide, and ethambutol. In cases with perilesional edema or paradoxical progression during treatment, addition of corticosteroids is preferred [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tuberculomas are seen to have resolved on follow up scans if they demonstrate calcifications or non-enhancement of previous enhancing lesions and these patients after completing therapy and do not have recurring symptoms then they don't need to be followed up [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Magic Dr.T? Tuberculous brain lesions in an immunocompetent patient-A case report

Saleh

Mango

et al. 2022

Radiology Case Reports

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Tuberculomas in the form of multiple ring-enhancing brain lesions is an uncommon occurrence in immunocompetent patient. Central nervous system tuberculosis may manifest as meningitis, tuberculoma, or abscess and can even occur in patients with or without active respiratory tract infection. In the case of active infection, specific antibiotic combinations and dosing duration are required, and respiratory isolation/precautionary measures must be taken by the health care workers and members of the family. Most literature has reported Central nervous system tuberculosis in patients with immunosuppression such as from HIV infection or solid organ transplantation; however, in endemic areas, CNS tuberculoma should be a differential consideration even for immunocompetent patients presenting with ring enhancing lesion (s). Our case highlights the importance of maintaining this clinical suspicion. Early diagnosis and management of our patient helped prevent potentially serious neurological sequelae.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Magic Dr.T? Tuberculous brain lesions in an immunocompetent patient-A case report

Saleh

Mango

et al. 2022

Radiology Case Reports

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“…Infection of MTB can result in the hematogenous or lymphatic spread of the pathogens, which can lead to pulmonary and extrapulmonary TB (Sutantoyo and Sugianto, 2022). CNS tuberculoma is a rare cause of intracranial masses; they are granulomas that form from an inflammatory response to MTB infection, with 3-4% of cases involving the cerebellum (Bouali et al, 2020), (Er et al, 2018). Cerebellar or brainstem tuberculoma is found at much lower rates in adults (Bouali et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Cerebellar tuberculoma in an immunocompetent patient

Sihombing

Sugianto

2022

ijhs

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Background: Tuberculosis infection of the Central Nervous System is the major cause of death and morbidity in developing countries. The clinical manifestations and radiological findings in tuberculoma are nonspecific. This article reports a rare case of cerebellar tuberculoma with the manifestation related to an intracranial mass and without the typical clinical symptoms of Tuberculosis in an immunocompetent patient. Case Report: A 20-year-old female with seizure, headache, and vertigo. A mass in the posterior fossa was revealed by Magnetic Resonance Imaging. Thorax scan results showed the Tuberculosis process. The patient then underwent surgery. Histopathological examination displayed chronic granulomatous inflammation and the presence of Acid-Fast Bacilli. The patient received anti-tuberculous drug treatment for one year and anti-seizure medication. Discussion: Cerebellar tuberculoma can resemble an intracranial tumor or cranial abscess. Diagnosis is based on clinical, radiological manifestations, and histopathological analysis. Surgical intervention still has a role in the treatment of this disease. The finding of Mycobacterium tuberculosis on histopathological examination is the gold standard in diagnosing Tuberculosis. Conclusions: Although it is rare, the involvement of Tuberculosis in the CNS should be taken into account in both immunocompetent and immunocompromised patients with neurological symptoms who are living in an endemic area.

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