Giant pituitary macroadenoma at the age of 4 months: case report and review of the literature

Abstract

Cushing's disease due to ACTH-secreting pituitary macroadenoma is a possible diagnosis in early infancy. This report, along with five previously reported cases in the literature, revealed a poor surgical outcome. This surgical morbidity is possibly attributed to difficult peroperative hemostasis due to vasculopathy in Cushing's disease, which leads to excessive blood loss, adverse hemodynamic changes, myocardial dysfunction and disseminated intravascular coagulopathy.

Congenital Immature Teratoma Mimicking Cushing’s Disease

“…Cushing’s disease is the commonest cause of CS after 5 years of age, though there have been case reports of functioning pituitary macroadenoma in infants [9]. The prognosis in these patients was uniformly poor and the cause of mortality was essentially sepsis, as in the present case [9]. …”

“…For example, CS in infancy is usually associated with McCune-Albright syndrome; adrenocortical tumors most commonly occur in children under 4 years of age [8]. Cushing’s disease is the commonest cause of CS after 5 years of age, though there have been case reports of functioning pituitary macroadenoma in infants [9]. The prognosis in these patients was uniformly poor and the cause of mortality was essentially sepsis, as in the present case [9].…”

ACTH-producing carcinoma of the pituitary with refractory Cushing's Disease and hepatic metastases: a case report and review of the literature

“…Pituitary carcinomas are rare neoplasms of the adenohypophysis, representing only 0.1–0.2% of all pituitary tumors[ 3 , 4 ]. To date, only 150 well-documented cases have been reported in the English literature[ 3 , 8 - 18 ]. ACTH-producing carcinomas represent 25% to 42% of endocrinologically active pituitary carcinomas[ 2 , 3 , 19 ].…”

Death from Neglected Pituitary Adenoma: A Case Report

“…Autopsy studies suggest that microadenomas(<10mm) occur in 10 to 20% of the population [2,3], while macroadenomas >10 mm are quite rare [4,5]. PA commonly produce ocular, or endocrine Case Report symptoms [6], others symptoms relate to mass effect as well as obstruction to cerebrospinal fluid(CSF) flow.Giant PA >/=4cm have been reported [7][8][9][10]. PA occur mostly in adults, but a case in infancy resulting in sudden death was reported [11].…”