“…Extended surgical excision or radical local excision with reconstruction of skin has been the primary treatment described (Ahsaini et al, 2013), and minimally invasive surgery has been favored as a first-line therapy (Spinu et al, 2014). Alternatives reported include CO 2 laser, electrocoagulation, radiation, intralesional injection of INF-alpha, or topical imiquimod (Akpadjan et al, 2017;Calderon-Castrat, Blanco, Santos-Duran, & Roncero-Riesco, 2017;Skowron, Raoulx, & Skowron, 2010). Cryotherapy (liquid nitrogen, nitric oxide) associated with topic chemotherapy has been proved effective in patients with small-sized tumors.…”