Giant Parathyroid Tumor: Parathyroid Adenoma versus Parathyroid Carcinoma

Abstract

Parathyroid adenoma is the most common cause of primary hyperparathyroidism (PHPT). We present the preoperative detection of a giant parathyroid adenoma (GPA) using (99mTc)-sestamibi parathyroid scintigraphy in a patient presenting with severely elevated parathyroid hormone, hypercalcemia, hypophosphatemia, and vitamin D insufficiency. The patient complained of cerebral symptoms and intermittent abdominal discomfort without constipation. After surgical removal of the hyperactive parathyroid gland and D vitamin supplementation, all blood tests were normalized. The clinical and paraclinical characteristics of GPA may raise the suspicion of parathyroid carcinoma, but not absolutely in this case.

Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report

“…This condition has an annual prevalence of about 21 cases per 100,000 people, and 85% of these cases are caused by a parathyroid adenoma 8 . Limited incidents of giant parathyroid adenoma (GPA) have already been observed since it is an uncommon cause of PHPT 9 . Patients may also exhibit high PTH and normalized calcium levels.…”

“…8 Limited incidents of giant parathyroid adenoma (GPA) have already been observed since it is an uncommon cause of PHPT. 9 Patients may also exhibit high PTH and normalized calcium levels. This condition is classified as normocalcemic hyperparathyroidism to distinguish it from secondary hyperparathyroidism.…”

Double Parathyroid Adenoma Presenting as One Mass: A Case Report

“…Once considered rare, primary hyperparathyroidism (PHPT) is a third most common endocrine disease, that has an incidence of 0.4 to 82 cases per 100 000 persons/year [1][2][3]. Prevalence of PHPT is higher in perimenopausal and postmenopausal women, for instance, in Scandinavian women of that age it is 2-5% while in elderly men it is 0.73% [1,4].…”

“…PHPT is characterized mainly by elevated parathyroid hormone (PTH) levels, hypercalcemia and hypophosphatemia [ 3 , 9 ]. When it comes to treatment, surgical intervention is curative with cure rates raising from 94 to 99% [ 7 ].…”

“…When it comes to treatment, surgical intervention is curative with cure rates raising from 94 to 99% [ 7 ]. The best method is considered to be minimally invasive parathyroidectomy regarding the reduction of surgical complications as well as the cost and length of hospitalization [ 3 ].…”