Giant Nevoid Hypertrichosis in an Iranian Girl

Abstract

A 12-year-old Iranian girl and her father had an extensive congenital nevus consisting of long, black terminal hair involving the entire back and the posterior surface of the arms without pigmentary changes of the underlying skin. A physical examination revealed no other abnormalities. In this study the possibility of a genetically determined etiology is considered.

Nevoid hypertrichosis: Case report with review of the literature

“…[1] Nevoid hypertrichosis is an uncommon congenital disorder consisting of terminal hair growth in a localized distribution. The skin lesions are usually present at or soon after birth and are typically solitary, though cases of multiple patches developing after puberty have been reported.…”

“…[2] The color of the terminal hair may be the same as the color of the scalp hair, rarely grey or white. [124] The histopathology usually shows a normal epidermis with increased number of morphologically normal hair follicles in the dermis but is needed to rule out any underlying nevus. [5]…”

“…Interestingly, an autosomal dominant mode of inheritance has been proposed in giant NH. [1] Lopez-Barrantes et al ., concluded that NH may occur in a mosaic pattern and may be associated with other cutaneous diseases that may show a segmental pattern as a twin spotting phenomenon with severe mental, ocular or myoskeletal anomalies or without any associated abnormalities. [6] Twin spots consist of two genetically different clones of neighboring cells in a background of normal cells.…”

“…Nevoid hypertrichosis (NH) is an uncommon disorder consisting of a solitary, circumscribed area of terminal hair growth present at or soon after birth. [12] The involved hair may be normal or hypo-pigmented, with or without any associated cutaneous and extra-cutaneous abnormalities. [2] We report a 12- year- old boy with localized hypertrichosis but without any underlying pigmentary or structural abnormality.…”

Nevoid hypertrichosis in a pre-adolescent girl

“…Mostly, it presents at or soon after birth;[1] although, uncommonly, it may present at a later age (around puberty). [2] The lesion is known to remain stable, with any increase in size being proportional to the growth of the child.…”