Giant Neurofibroma in the Right Lower Limb of a 26-Year-Old Woman: Report of a Case

Zhou, Jianda; Li, Ming; Luo, Chengqun; He, Qing-Yu; Yin, Zhu; Peng, Hao; Chen, Zizi; Chen, Jiye; Su, Zhong; Xie, Hui-Qing

doi:10.9738/cc2.1

Cited by 12 publications

(11 citation statements)

References 8 publications

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“…To ensure optimal outcomes a multidisciplinary surgical team is advantageous. There are very few case reports that discuss plexiform neurofibroma resections in the lower limbs [9–13] and our case adds to the evidence for preoperative embolization to ensure safe resection. There are also reports in the literature of a resection of a plexiform neurofibroma infiltrating the middle and lower parts of the patient's face [14] and reports of spinal neurofibromas removal [15] .…”

Section: Discussionmentioning

confidence: 67%

Hybrid resection of a giant thigh plexiform neurofibroma

Kolker

Wunder

Roche-Nagle

2015

International Journal of Surgery Case Reports

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HighlightsMassive plexiform neurofibromatosis is a rare expression of von Recklinghausen’s disease or Type 1 neurofibromatosis.Tumor progression is a serious problem for patients with a plexiform neurofibroma due to the debilitating nature of the disease to a patient’s function and potential for malignant transformation.Treatment has two goals, to restore function and to restore cutaneous appearance. This demands a multidisciplinary approach with preoperative embolization central to minimize peri-operative hemorrhage.

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Section: Discussionmentioning

confidence: 67%

Hybrid resection of a giant thigh plexiform neurofibroma

Kolker

Wunder

Roche-Nagle

2015

International Journal of Surgery Case Reports

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“…[4–6] However, we agree that the most difficult challenge for this surgery is the variation of anatomy and unclear tumor margin. In addition, the tumor contains thickened cord of nerves along with abundant abnormal vessels; therefore, excessive hemorrhage during the operation is also a brainteaser.…”

Section: Discussionmentioning

confidence: 95%

Lady with wings

Maharjan

Li²,

Cui³

et al. 2017

Medicine

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Rationale:Neurofibromatosis type I (NF-I) accounts for approximately 90% of neurofibromatosis. NF-I is an autosomal dominant genetic disease which results from the gene mutation of NF-I situated in chromosome 17q11.2.Patient concerns:A 32-year-old lady presented with a giant wing like structure on her back which started growing from her childhood.Diagnosis:A diagnosis of NF-I was confirmed as she presented with multiple cutaneous nodules, multiple café-au-lait macules of different sizes, scoliosis deformity, and positive family history of neurofibroma.Interventions:Surgical excision of tumor and multiple Z plasty reconstruction of the back was carried out.Outcomes:The excised neurofibroma weighed 6.7 kg containing thickened nerves, nerve roots, and circuitous vessels. The histopathological report confirmed plexiform and diffuse type cutaneous neurofibroma without any malignant transformation. Surgical excision and reconstruction with regular follow-up is an excellent choice of treatment for such a giant neurofibroma as in this case.Lessons:NF-I is a genetic disease which could present as a giant cutaneous neurofibroma. One of the treatment options for giant neurofibromas causing deformity and physical disability is by surgical excision and histopathological examination with regular follow-up for NF-I recurrence.

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“…9 There are very few case reports that discuss plexiform neurofibroma resections in the lower limbs. 10,11,12 Giant neurofibroma is a poorly defined term used to describe a neurofibroma that has grown to a significant but undefined size. However, the term "giant neurofibroma" be used for referring to those neurofibromas weighing 20% or more of the patient's total corporal weight.…”

Section: Case Reportmentioning

confidence: 99%

Large intramuscular plexiform neurofibroma of thigh: a multidisciplinary team approach

Mandal¹,

Kumar²,

Sinha³

et al. 2020

Int J Res Orthop

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<p>Large plexiform neurofibroma of lower extremity involving the muscle is a rare entity. In this article we present the case of plexiform neurofibroma of right thigh involving the muscular plane and entrapment of the sciatic nerve. A 28 year lady presented with a plexiform neurofibroma of right thigh of size 60 cm×30 cm×25 cm with a positive family history of neurofibromatosis type 1. MRI was done for the assessment of the tumour and the adjacent structure involvement. The neurofibroma was removed with a multidisciplinary team approach with an intensive peri operative management. The pathological diagnosis was plexiform neurofibroma with diffuse neurofibroma. We have reported a rare case of large plexiform neurofibroma of lower extremity with muscle involvement and nerve entrapment.</p>

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Giant Neurofibroma in the Right Lower Limb of a 26-Year-Old Woman: Report of a Case

Cited by 12 publications

References 8 publications

Hybrid resection of a giant thigh plexiform neurofibroma

Hybrid resection of a giant thigh plexiform neurofibroma

Lady with wings

Large intramuscular plexiform neurofibroma of thigh: a multidisciplinary team approach

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