Giant multilocular cystadenoma of the prostate responsive to GnRH antagonists

Datta, Milton W.; Hosenpud, Janet; Osipov, Vladimir; Young, Robert H.

doi:10.1016/s0090-4295(02)02109-x

Cited by 25 publications

(25 citation statements)

References 9 publications

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“…Prostatic cystadenoma is usually characterized by large multilocular cysts that are located between the rectum and the bladder. The clinical presentation includes obstructive voiding symptoms, such as poor stream, intermittency, straining, and a sensation of incomplete emptying, and also defecation symptoms that result from the compression of the lower gastrointestinal system [1-10]. These lesions do not invade adjacent structures or show any malignant characteristics.…”

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confidence: 99%

Giant Multilocular Cystadenoma of the Prostate: A Rare Cause of Huge Cystic Pelvic Mass

et al. 2012

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Giant multilocular prostatic cystadenoma is a rare benign tumor that evolves from the prostate gland. Obstructive voiding symptoms occur in all reported cases. These lesions do not invade adjacent structures. Preoperative radiologic evaluation can define the benign nature of the lesion. Here we report a case of large cystic lesions identified by magnetic resonance imaging and sonographic findings that caused an extensive mass effect in the pelvis. When retrovesical, huge cystic lesions fill the pelvis completely in young men, with high levels of serum prostate-specific antigen, giant multilocular prostatic cystadenoma should be considered as a differential diagnosis. To our knowledge, this is the youngest case of prostatic cystadenoma reported in the literature.

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confidence: 99%

Giant Multilocular Cystadenoma of the Prostate: A Rare Cause of Huge Cystic Pelvic Mass

et al. 2012

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“…The sequelae or natural history of the disease prostate cyst adenoma still remains a mystery and there is still not a generally accepted consensus on optimum management. Surgery is currently the preferred treatment option despite Datta et al reporting otherwise [3]. Surgery provides samples for pathological diagnosis as well as a cure.…”

Section: Resultsmentioning

confidence: 99%

“…Maluf et al described this pathology in 1991 and proposed the name prostate cyst adenoma by Maluf et al in 1991 [1]. Most patients present with voiding and storage urinary symptoms mimicking benign prostate hyperplasia [2,3]. A few of the patients present with haematuria [4] abdominal distention, abdominal mass [5,6] constipation [6] or infertility [7,8].…”

Section: Discussionmentioning

confidence: 99%

Does Giant Multilocular Cystadenoma of Prostate Respond to LHRH Agonist or It Is a Case of Cystic Prostate Cancer Wrongly Diagnosed– A Report of 3 Cases and Review of Literature

Hammond¹,

Bradley²,

Ramani³

et al. 2017

J Clin Case Rep

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A retrospective review of radiology registry identified 3 cases of diagnosed giant multilocular cystadenoma of prostate. The first case illustrates a 59-year-old man with worsening voiding and storage symptoms of 2 months duration. The prostate was enlarged with the right lobe being bigger than the left node and his PSA was 9.3 ug/l. MRI showed large Multi cystic mass from the prostate and TRUS biopsy revealed adenocarcinoma prostate. Neoadjuvant LHRH agonist shrunk the mass before radiotherapy. He has no urinary symptoms and PSA consistently less than 0.1. Repeat MRI showed highly shrunken mass. In the second case, we present a 79-year-old patient presenting with rising PSA despite being on finasteride. MRI diagnosed large cystic and solid mass arising from the prostate and extending to the abdomen. Tran's rectal ultrasound guided biopsy plus aspiration of the fluid from the multiloculated cyst revealed benign cystic adenoma with no evidence of any malignancy. Repeat MRI after 6 months of LHRH agonist showed multiloculated cyst adenoma of the prostate appears stable with no significant reduction in size and his PSA remains high. The third case is an 83-year-old presenting with LUTS, haematuria and rising PSA. He has a past medical history of low grade prostate cancer (diagnosed at TURP). MRI scan showed an enlarged echogenic prostate. TRUS biopsy of the mass identified complex proliferation of atypical glandular epithelium in a rather villous adenomatous pattern. Neoadjuvant LHRH agonist showed reduction in lower urinary symptoms. Keywords: Multilocular cystadenoma; Luteinising hormone releasing hormone; Cystic prostate cancer Case Reports Case 1A 59-year-old Caucasian man presented with both worsening urinary voiding and storage symptoms of 2 months duration. In addition, he complained of dysuria but he denied fever, chills, rigors or penile discharges. He has background history of hypertension and impaired glucose tolerance. He is a non-smoker and moderately consumes alcohol. On examination, his external genitalia were normal. The prostate was enlarged and non-tender. The right lobe of the prostate was bigger and irregular with palpable nodules. Urinalysis was negative and mid-stream urine grew no organism. His prostate specific antigen (PSA) was 9.3 ug/l. His flow rate was 15 ml/s and had a residual volume of 50 ml. In view of his high prostate specific antigen (PSA) and enlarged prostate, a Trans Rectal Ultrasound (TRUS) guided biopsy was done and revealed a focus of 3+4 (mostly 3) adenocarcinoma prostate. Magnetic Resonance Imaging (MRI) requested for staging showed a large multi-cystic mass lesion arising from lateral aspect of base of prostate, displacing bladder base superiorly and extending down right side of prostate to para-urethral tissues in the region of membranous urethra. Bone scan was negative. At urology, multidisciplinary team (MDT) an option of Luteinizing Hormone-Releasing Hormone (LHRH) was started with the aim of shrinking the mass to make it operable or to have radiotherapy. Repe...

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“…2 Our review of the literature revealed 15 similar cases. [1][2][3][4][5][6][7][8][9][10][11][12][13] The clinical presentation in all of these patients with multilocular prostatic cystadenoma classically included obstructive voiding symptoms. Because these tumors tend to attain massive proportions, they produce a mass effect …”

Section: Discussionmentioning

confidence: 99%