Giant mesenteric myxoid liposarcoma: Challenges of diagnosis and treatment

Mokfi, Rania; Boutaggount, Farah; Maskrout, Meryem; Rais, Ghizlane

doi:10.1016/j.radcr.2022.08.005

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…The histopathological investigation of MPNST in this work confirms well-known features of these aggressive neoplasms (Figure 7 ). Previous studies have consistently shown an infiltrative growth pattern and the presence of pleomorphic nuclei, which are generally symptomatic of high-grade malignancy [ 13 ]. These characteristics highlight the aggressive nature of MPNSTs and the importance of early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

The Expression of Mucin-4 (MUC4) in Sarcomas Apart From Sclerosing Epithelioid Fibrosarcoma and Low-Grade Fibromyxoid Sarcoma

Hassan,

Saeed,

Mushtaq

et al. 2023

Cureus

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Background Low-grade fibromyxoid sarcoma (LGFMS) and sclerosing epithelioid fibrosarcoma (SEF) are two rare but aggressive soft tissue sarcomas that can be difficult to distinguish due to histopathological similarities. The present study examines the diagnostic capacities of mucin-4 (MUC4), a transmembrane mucin, in identifying different types of sarcomas and broadens its evaluation to include a wide range of sarcomas. Methods Immunohistochemical (IHC) examination of tissue samples from various sarcomas was performed using a mouse anti-MUC4 monoclonal antibody. IHC was conducted on 4-mm thick formalin-fixed paraffin-embedded tissue sections after pressure cooker antigen retrieval with a mouse anti-MUC4 monoclonal antibody. Results MUC4 was shown to be highly expressed in SEF (n=13) and LGFMS (n=10), while focal positivity in synovial sarcoma (n=1). Other sarcomas, such as malignant peripheral nerve sheath tumors, fibrosarcoma, leiomyosarcoma, liposarcoma, and myxofibrosarcoma, exhibited no expression (n=0). These findings are consistent with previous research and support MUC4 specificity as a SEF and LGFMS marker. This study provides information on the diagnostic efficacy of MUC4, particularly in the context of certain subtypes. It not only helps our understanding of these unique instances, but it also provides context for histopathological and IHC findings in soft tissue sarcoma. Furthermore, this study investigates the influence of age and gender on MUC4 expression in a range of sarcomas, which was typically understudied in the literature and found no relation with expression of MUC4. Conclusion In conclusion, this study adds to our understanding of soft tissue sarcomas by emphasizing the crucial role of MUC4 in certain sarcoma subtypes while acknowledging the complex variety of the sarcoma landscape. Further research is needed to understand the molecular mechanism that governs marker expression patterns, as well as the therapeutic implications.

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Section: Discussionmentioning

confidence: 99%

The Expression of Mucin-4 (MUC4) in Sarcomas Apart From Sclerosing Epithelioid Fibrosarcoma and Low-Grade Fibromyxoid Sarcoma

Hassan,

Saeed,

Mushtaq

et al. 2023

Cureus

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“…Metaphase fluorescence in situ hybridization (FISH) with a break-apart probe specific for the EWSR1 gene. An intact yellow signal is seen on the normal chromosome 22, whereas a split signal is seen on the derivative chromosomes 11 (green) and 22 (red) [ 26 , 27 ] …”

Section: Discussionmentioning

confidence: 99%

Extraskeletal myxoid chondrosarcoma of the gingival: a rare case report and review of the literature

Li,

Zheng,

Deng

et al. 2023

Diagn Pathol

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Background Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant tumor described in the head and neck region, especially in the gingival. We present one case arising in the gingival of right mandible, and briefly reviewed the related literature. Case presentation A 24-year-old male patient with a lesion of 3.5*2.0 cm in buccal gingival of right posterior mandible for 2 months. The tumor was composed of cartilaginous structures and myxoid matrix. Immunohistochemical(IHC) showed that the tumor cells to be positive for vimentin, focally positive for S-100, negative for calponin, SMA, SOX10. The Ki-67 labelling index was 80%. Fluorescent in situ Hybridization (FISH) was positive for NR4A3 rearrangement. Conclusions Due to its unusual site and low incidence in the oral region, a combination of histological findings, immunohistochemistry, and molecular pathology as well as differential diagnosis with other diseases should be taken into consideration in the process of clinical diagnosis and treatment.

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“…Although liposarcomas are common tumors of the retroperitoneum, primary mesenteric liposarcomas are extremely rare neoplasms. It was not until 1951 that it was first described in the literature by Manson [3] and the presence of only 23 well-described reported cases of mesenteric liposarcomas in literature is a testimony of this fact [4]. They are known to grow relentlessly into large tumors and become symptomatic due to compression on adjacent organs.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Primary Mesenteric Liposarcoma

Ahire¹,

Myrthong²,

Mahankudo³

et al. 2023

Cureus

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Primary mesenteric liposarcoma is a rare soft tissue malignant neoplasm. The authors present a case of a 42year-old male with pain in the abdomen and abdominal mass which showed a desmoid tumor on biopsy and CT shows a mesenteric mass present. The patient underwent exploratory laparotomy and a large tumor was excised. The specimen was sent for histopathology and showed dedifferentiated liposarcoma of the mesentery. Immunohistochemistry showed the tumor cells are diffusely positive for mouse double minute 2 (MDM2), p16, and show patchy positivity for the cluster of differentiation (CD) 34. The cells are negative for smooth muscle actin (SMA), desmin, S100, and ckit. After the surgery, the patient recovered well and was given adjuvant chemotherapy with doxorubicin, ifosfamide, and mesna. The patient has no signs or symptoms of recurrence to date. In this case, the combination of surgery and chemotherapy has shown to have a good clinical outcome.

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Giant mesenteric myxoid liposarcoma: Challenges of diagnosis and treatment

Cited by 5 publications

References 10 publications

The Expression of Mucin-4 (MUC4) in Sarcomas Apart From Sclerosing Epithelioid Fibrosarcoma and Low-Grade Fibromyxoid Sarcoma

The Expression of Mucin-4 (MUC4) in Sarcomas Apart From Sclerosing Epithelioid Fibrosarcoma and Low-Grade Fibromyxoid Sarcoma

Extraskeletal myxoid chondrosarcoma of the gingival: a rare case report and review of the literature

A Rare Case of Primary Mesenteric Liposarcoma

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