Giant Mediastinal Thymolipoma in 35-Year-Old Women

Aghajanzadeh, Manouchehr; Alavi, Ali; Pourrasouli, Zahra; Aghajanzadeh, Gilda; Massahnia, Sara

doi:10.5681/jcvtr.2011.014

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Here, we report a case of thymolipoma in a 23-year-old male. The tumor weighed more than 7 kg, and to our knowledge, it was the largest reported excised tumor of thymic origin, including various benign and malignant thymic neoplasms[ 5 - 9 ]. The mass was too large for en bloc resection by a sternotomy, so a posterolateral incision for piecemeal resection was selected as the surgical technique.…”

Section: Introductionmentioning

confidence: 99%

Surgical resection of a giant thymolipoma causing respiratory failure: A case report

Gong¹,

Wang²,

Zhou³

et al. 2023

World J Clin Cases

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BACKGROUND Thymolipoma is a rare benign tumor arising from the anterior mediastinal thymus and is composed of mature fatty tissue and interspersed nonneoplastic thymic tissue. This tumor accounts for only a small percentage of mediastinal masses, and the majority of them are asymptomatic and found incidentally. To date, fewer than 200 cases have been published in the world literature, of which most excised tumors weighed less than 0.5 kg and the largest weighed 6 kg. CASE SUMMARY A 23-year-old man presented with a complaint of progressive breathlessness for 6 mo. His forced vital capacity was only 23.6% of the predicted capacity, and his arterial partial pressure of oxygen and carbon dioxide were 51 and 60 mmHg, respectively, without oxygen inhalation. Chest computed tomography revealed a large fat-containing mass in the anterior mediastinum that measured 26 cm × 20 cm × 30 cm in size and occupied most of the thoracic cavity. Percutaneous mass biopsy revealed only thymic tissue without signs of malignancy. A right posterolateral thoracotomy was successfully performed to remove the tumor along with the capsule, and the excised tumor weighed 7.5 kg, which to our knowledge, was the largest surgically removed tumor of thymic origin. Postoperatively, the patient’s shortness of breath was resolved, and the histopathological diagnosis was thymolipoma. No signs of recurrence were observed at the 6-mo follow-up. CONCLUSION Giant thymolipoma causing respiratory failure is rare and dangerous. Despite the high risks, surgical resection is feasible and effective.

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Section: Introductionmentioning

confidence: 99%

Surgical resection of a giant thymolipoma causing respiratory failure: A case report

Gong¹,

Wang²,

Zhou³

et al. 2023

World J Clin Cases

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Giant Mediastinal Thymolipoma Mimicking Teratoma

Sureka

Agarwal

2014

Apollo Medicine

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A young female presented to us with chest complaints of 10 months duration. Imaging was done which revealed fat attenuation mass lesion in the mediastinum occupying both hemithoraces. Provisional differential diagnosis of giant teratoma, mediastinal thymolipoma, large pleural lipoma or a pulmonary lesion with effusion was kept. Patient underwent surgery, mass was resected and the patient discharged in good condition.

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Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors

et al. 2022

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Describing the changes in surgical procedures and factors affecting the surgical outcome of patients who have undergone complete resection of giant mediastinal tumors (GMTs, diameter ≥ 10 centimeters) could improve preoperative decision-making and prognostic evaluations. We accessed data from three sources, which are case reports on surgical treatment of GMTs from PubMed, Web of Science, and EMBASE until June 1, 2019; patients with resected GMT from the Surveillance, Epidemiology, and End Results (SEER) database; and retrospective review of medical records in our institution from 2000 to 2019. The worldwide distribution, clinicopathological characteristics, symptom profile, prognosis of patients with GMT resection, and nomogram for surgical outcome prediction are reported. A total of 242 rare GMT cases from four continents (Asia, North America, South America, and Europe) were included. The median age of the patients was 40 (IQR: 27, range: 13–83) years, and the male-to-female ratio was 1.57:1. Dyspnea, shortness of breath, cough, and chest pain or discomfort were the major symptoms at presentation. The prognosis of benign and low-grade malignant GMTs was superior to that of high-grade malignant GMTs. Tumor malignancy played the most critical role in predicting postoperative survival, followed by longest tumor diameter and a posterior mediastinum location. The findings of this study suggest that the number of successful GMT surgeries has increased over the last decade and describe clinical features of GMTs. Physicians should prioritize tumor malignancy as a leading factor in predicting outcome rather than tumor size.

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Giant Mediastinal Thymolipoma in 35-Year-Old Women

Cited by 4 publications

References 6 publications

Surgical resection of a giant thymolipoma causing respiratory failure: A case report

Surgical resection of a giant thymolipoma causing respiratory failure: A case report

Giant Mediastinal Thymolipoma Mimicking Teratoma

Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors

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