Giant Magnetoresistance Biosensors for Food Safety Applications

Abstract

Nowadays, the increasing number of foodborne disease outbreaks around the globe has aroused the wide attention of the food industry and regulators. During food production, processing, storage, and transportation, microorganisms may grow and secrete toxins as well as other harmful substances. These kinds of food contamination from microbiological and chemical sources can seriously endanger human health. The traditional detection methods such as cell culture and colony counting cannot meet the requirements of rapid detection due to some intrinsic shortcomings, such as being time-consuming, laborious, and requiring expensive instrumentation or a central laboratory. In the past decade, efforts have been made to develop rapid, sensitive, and easy-to-use detection platforms for on-site food safety regulation. Herein, we review one type of promising biosensing platform that may revolutionize the current food surveillance approaches, the giant magnetoresistance (GMR) biosensors. Benefiting from the advances of nanotechnology, hundreds to thousands of GMR biosensors can be integrated into a fingernail-sized area, allowing the higher throughput screening of food samples at a lower cost. In addition, combined with on-chip microfluidic channels and filtration function, this type of GMR biosensing system can be fully automatic, and less operator training is required. Furthermore, the compact-sized GMR biosensor platforms could be further extended to related food contamination and the field screening of other pathogen targets.

Quartz crystal microbalance–based aptasensor integrated with magnetic pre-concentration system for detection of Listeria monocytogenes in food samples

“…By using this method, specific interactions between the target bacterium and the recognition molecule on the QCM chip surface could be created for the quick determination of foodborne pathogens in food samples. Although many methods have been reported to detect pathogens in food samples, nonspecific interactions hinder real-life applications of sensor systems [ 19 , 25 – 27 ]. Therefore, the magnetic pre-enrichment technique has been used to prevent the interaction of impurities with the QCM system for the isolation of protein, cells, and fine chemicals from complex solutions without using expensive laboratory equipment.…”

Non-contact Respiration Monitoring Using Bio- Radar Sensor Based on Linear Regression Classifier

“…Traditional techniques, characterized by their time-consuming and labor-intensive nature, are being surpassed by innovative biosensing platforms. The giant magnetoresistance (GMR) biosensors, fueled by nanotechnological advancements, emerge as a promising solution for revolutionizing current food surveillance approaches [13]. Test results revealed the system's ability to detect stop breathing.…”

Giant Magnetoresistance Based Biosensors for Cancer Screening and Detection

“…The resistance change, Δ R , exhibits high sensitivity toward magnetic labels, enabling the detection and quantification of biological analytes. GMR-based biosensors have demonstrated reliable performance and have been extensively employed in diverse fields such as biotechnology, medical diagnostics, environmental monitoring, and more. − Their versatility and sensitivity make them valuable tools in various applications.…”