Giant Keratocystic Odontogenic Tumor of the Mandible – A Case Report

Abstract

SummaryBackgroundThe keratocystic odontogenic tumor (KCOT) is a relatively rare, benign neoplasm which develops in the maxilla or mandible, arising from the dental lamina or basal cells of the oral epithelium. It is often found incidentally and brings about late symptoms as it does not cause bone distension for a long time.Case ReportThe presented case is of a young woman with a giant keratocystic odontogenic tumor of the mandible.ConclusionsDespite its rare occurrence, it must be taken into consideration in radiological and clinical diagnostics. Due to the frequent recurrence of KCOT, patients are recommended to be kept under long-term and close radiological supervision.

Synthesis of Lupane‐Type Saponins Containing an Unusual α‐D‐Idopyranoside Fragment as Potent Cytotoxic Agents

“…Glycosylation of 3‐ O ‐acetylbetulinic acid 1 24 was performed by treatment with peracetylated ( 7 ) or perbenzoylated ( 8 ) D ‐idopyranosyl trichloroacetimidate in the presence of TMSOTf under standard conditions 25. Protected esters were obtained in high yields (89 % for 20 and 86 % for 21 ).…”

“…Herein, we report on the synthesis of perbenzoylated D ‐idose derivatives, as well as novel lupane‐type saponins bearing a D ‐idopyranoside moiety, and their anticancer properties determined by a cytotoxicity evaluation of these compounds. This is a continuation of our research on the synthesis and utility of saponins obtained from triterpenes isolated from white birch bark 24–26. The synthetic strategy is directed toward glycosylation of 3‐ O ‐acetylbetulinic acid 1 , betulin derivatives 2 – 4 , lupeol ( 5 ), and 28‐ O ‐acetyl‐ epi ‐betulin ( 6 ) with D ‐idopyranosyl trichloroacetimidates 7 39 and 8 (Figure 1).…”

Big keratocystic odontogenic tumor of the mandible: a case report

“…Furthermore, tooth resorption is rare while tooth dislocation is more common. Large tumors invade the soft tissue after damaging the compact external bone lamella (7). KCOTs are seldom large-sized; the dimension of our patient's lesion was16 x17 cm.…”

Synthesis of lupane saponins from acetylated glycosyl donors by acetonitrile directed glycosylation

“…They occur in nature less frequently than those having other triterpene-type aglycones, although a growing interest in their synthesis is noticeable. [3][4][5][6][7][8][9][10][11][12] They possess interesting biological properties including antitumor, antiviral, antifungal, and antiinflammatory activities, which have been extensively studied and reviewed in the last years. [13][14][15][16][17][18] Unfortunately, glycosylation of lupane type triterpenes M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 3/12 with acetylated glycosyl donors usually fails, due to the acetyl migration from donor to acceptor molecule.…”