Giant Intramural Left Ventricular Rhabdomyoma in a Newborn

Padalino, Massimo A.; Vida, Vladimiro L.; Bhattarai, Anil; Reffo, Elena; Milanesi, Ornella; Thiene, Gaetano; Stellin, Giovanni; Basso, Cristina

doi:10.1161/circulationaha.111.017897

Cited by 18 publications

(9 citation statements)

References 4 publications

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“…These non-proliferating collections of cardiomyocytes expressed cardiac markers, but had overly abundant glycogen exhibiting a hamartoma-like phenotype 40, 41 . The exact histogenesis of these foci is not known, but reports in pediatric cardiac hamartomas have indicated that they may regress over time 42 .…”

Section: Discussionmentioning

confidence: 99%

Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model

Riegler

Tiburcy

Ebert

et al. 2015

Circulation Research

208

168

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Rational Tissue engineering approaches may improve survival and functional benefits from human embryonic stem cell-derived cardiomyocte (ESC-CM) transplantation, thereby potentially preventing dilative remodelling and progression to heart failure. Objective Assessment of transport stability, long term survival, structural organisation, functional benefits, and teratoma risk of engineered heart muscle (EHM) in a chronic myocardial infarction (MI) model. Methods and Results We constructed EHMs from ESC-CMs and released them for transatlantic shipping following predefined quality control criteria. Two days of shipment did not lead to adverse effects on cell viability or contractile performance of EHMs (n=3, P=0.83, P=0.87). After ischemia/reperfusion (I/R) injury, EHMs were implanted onto immunocompromised rat hearts at 1 month to simulate chronic ischemia. Bioluminescence imaging (BLI) showed stable engraftment with no significant cell loss between week 2 and 12 (n=6, P=0.67), preserving up to 25% of the transplanted cells. Despite high engraftment rates and attenuated disease progression (change in ejection fraction for EHMs −6.7±1.4% vs control −10.9±1.5%, n>12, P=0.05), we observed no difference between EHMs containing viable or non-viable human cardiomyocytes in this chronic xenotransplantation model (n>12, P=0.41). Grafted cardiomyocytes showed enhanced sarcomere alignment and increased connexin 43 expression at 220 days after transplantation. No teratomas or tumors were found in any of the animals (n=14) used for long-term monitoring. Conclusions EHM transplantation led to high engraftment rates, long term survival, and progressive maturation of human cardiomyocytes. However, cell engraftment was not correlated with functional improvements in this chronic MI model. Most importantly, the safety of this approach was demonstrated by the lack of tumor or teratoma formation.

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Section: Discussionmentioning

confidence: 99%

Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model

Riegler

Tiburcy

Ebert

et al. 2015

Circulation Research

208

168

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“…13,14 Early identification with fetal echo cardiography, associated with a complete postnatal eva luation, enables prompt postnatal treatment with life saving surgical resection of the mass when significant hemodynamic compromise or lifethreatening arrhythmias are present. 4,15,16 Genetic counseling is also required when we have a patient with cardiac tumors.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Tumors in the Neonatal Period: Clinical Features and Echocardiographic Evaluation

Hășmășanu¹,

Oprita²,

Kovacs³

et al. 2014

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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“…This lends itself to imaging, and congenital heart images brighten up the pages of many major cardiac journals. Therefore it seems appropriate to end this Almanac with reference to some of the more stunning images that reflect the key areas in congenital heart disease that were discussed above, including intervention, [85][86][87][88][89][90][91] foetal and neonatal, [92][93][94][95] heart failure and mechanical support, 9 adolescent and adult congenital heart disease, 97,98 advanced imaging with MRI and CT 99,100 and unusual morphology. [101][102][103][104][105][106][107] All of which are well worth a look to brighten up a night catching up on the cardiac journals.…”

Section: Images Of Congenital Heart Diseasementioning

confidence: 99%

Almanac 2012: Congenital heart disease. The national society journals present selected research that has driven recent advances in clinical cardiology

Burch

Dedieu

2013

Revista Portuguesa de Cardiologia

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Giant Intramural Left Ventricular Rhabdomyoma in a Newborn

Cited by 18 publications

References 4 publications

Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model

Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model

Cardiac Tumors in the Neonatal Period: Clinical Features and Echocardiographic Evaluation

Almanac 2012: Congenital heart disease. The national society journals present selected research that has driven recent advances in clinical cardiology

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