Giant Hemosiderotic Dermatofibroma

Adenodermatofibromas are an extremely rare subtype of dermatofibroma (DF) characterized by a dermal proliferation of spindle-shaped fibroblasts and histocytes, dilated glandular structures with apocrine secretion, and prominent vascular proliferation, with or without hemosiderotic features. We describe a recent extraordinary case of a hemosiderotic adenodermatofibroma in a 25-year-old female. We review histologic findings and theories behind etiology, as well as review the spectrum of clinical presentations for this lesion. We also discuss imaging findings that may make identification of these entities challenging.

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“…3 Here, we report a new case of a giant (>5 cm) hemosiderotic adenodermatofibroma with clinical workup. 4…”

Section: Introductionmentioning

confidence: 99%

Giant Hemosiderotic Adenodermatofibroma: A Case Report and Review of the Literature

Andrasik

Tamburro

2023

The American Journal of Dermatopathology

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Hemosiderotic dermatofibroma mimicking melanoma: A case report and review of the literature

Allen

Loxas

et al. 2021

Clinical Case Reports

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is a common benign skin tumor. Hemosiderotic dermatofibroma (HDF) is a rare variant of DF. It often mimics other skin lesions including melanocytic lesions and vascular tumors. In this report, we described the clinical features and histopathological findings of a rare HDF case that mimics melanoma. Dermatofibroma (DF) is a common benign cutaneous lesion generally reported in the trunk or extremities of young or middle-aged adults with a slight predominance in females. 1,2 Based on specific histopathological features, DF has multiple variants which may include but not limited to aneurysmal/hemosiderotic, 3 cellular, 4 epithelioid cell histiocytoma, 5 atypical (pseudosarcomatous), 6 atrophic, 7 and lipidized. 8 It usually presents as a solitary well-circumscribed nodule with reddish/ brown color on gross examination and central white patch and peripheral pigment network on dermatoscopy. 9 However, this disease has a wide range of presentations. About 29% DF cases harbor atypical macroscopic features resembling other skin malignancies including melanoma (16% of all cases), vascular tumor, and basal cell carcinoma. 10 Hemosiderotic DF (HDF) is a rare variant of DF which is known to have melanoma-like pattern. Skin examination by dermatoscopy is not able to reliably distinguish HDF from melanoma. 10,12 In this scenario, a definite diagnosis could only be made by histopathological examination. There are three cases of HDF reported in the literature from the United States. 13-15 Here, we report another case of HDF which was clinically suspicious for melanoma.

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