Giant ganglioneuroma of the posterior mediastinum

Hayat, Javed; Ahmed, Riaz; Alizai, Shereen; Awan, Muhammad Umer

doi:10.1510/icvts.2011.267393

Cited by 22 publications

(19 citation statements)

References 9 publications

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“…Patients with these tumors are often asymptomatic and are incidentally detected on imaging for other purposes in late childhood [2] . Although benign and often asymptomatic, intrathoracic GN may grow aggressively compressing vital structures such as the spinal cord and tracheobronchial tree leading to neurologic and respiratory symptoms [3] , [4] 5] . The CT appearance of a GN is usually nonspecific, however the differential diagnosis tends to be limited to other neuroblastic tumors given their characteristic location.…”

Section: Introductionmentioning

confidence: 99%

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Brock

Sharma

Villada

et al. 2021

Radiology Case Reports

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Ganglioneuromas (GN) are rare, mature tumors that arise in the posterior mediastinum or retroperitoneum from neural crest cells and present as slow growing masses in the pediatric population. While they are often found incidentally in unrelated diagnostic workup, they can become symptomatic due to their size and location. They typically demonstrate the nonspecific appearance of a solid mass without invasive or destructive features across different modalities. Such features are normally indicative of more aggressive neoplasms from similar cellular ancestry or an entirely different lineage. Here we present a case of mediastinal GN that on imaging was initially suggestive of an osteochondroma with malignant degeneration based on the presence of an exostosis associated with a large solid mass. Final pathology, however, revealed GN with involvement of the adjacent bone. While the final diagnosis was benign, it is important to recognize this pattern of exostosis with solid mass, especially since the overall survival rate of sarcomata is much worse than that of a classic GN.

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Section: Introductionmentioning

confidence: 99%

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Brock

Sharma

Villada

et al. 2021

Radiology Case Reports

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“…With the recent improvements in radiological imaging, the number of incidentalomas found has increased [2,5,8] . On CT, ganglioneuromas predominantly exhibit low to intermediate signal intensity.…”

Section: Discussionmentioning

confidence: 99%

Posterior mediastinal ganglioneuroma:A case report and literature review

Jing

Sun

Guo

et al. 2017

Transl. Neurosci. Clin.

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Objectives: Ganglioneuroma is a rare, benign neurogenic tumor arising from the sympathetic ganglia. In this report, we reviewed and summarized the clinical features, treatment, and prognosis of a posterior mediastinal ganglioneuroma.Case: Here, we report on a 29-year-old man referred to us with transient pain in the right side of the chest, lasting for three days. Physical examination revealed no abnormalities.The results of routine laboratory tests were within the normal ranges. Thoracic spinal magnetic resonance imaging showed a well-defined, solid mass in the right paravertebral region at the T5-T8 level, measuring 7.5 cm × 4.2 cm × 1.5 cm. To accurately locate the lesion during surgery, O-arm intraoperative imaging was used in conjunction with the Stealth Station navigation system. The tumor was completely excised and no related complications occurred. The tumor was an encapsulated mass with a solid, homogenous, grayish-tan cut surface. Histopathological examinations confirmed that the mass was a ganglioneuroma.Conclusions: Ganglioneuroma is a rare, benign tumor. Prior to treatment, a careful imaging evaluation is necessary in order to obtain an accurate diagnosis. A definitive diagnosis can be made by histological examination. En bloc resection is the preferred treatment for ganglioneuroma as it has an excellent prognosis.

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“…Ganglioneuroma is a rare, slow-growing, benign tumor that arises from sympathetic ganglion along the spinal column and adrenal glands [1][2][3][4][5]. Most of ganglioneuromas are found in the posterior mediastinum and retroperitoneum, and less than 10 % in the spine [6,7]. Ganglioneuromas may be present in any part of the spine with more prevalence in the thoracic region [6].…”

Section: Introductionmentioning

confidence: 99%

Single stage complete resection of giant dumbbell lumbar ganglioneuroma: a case report and review of the literature

Wang

Jian

et al. 2016

Chin Neurosurg Jl

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Background: Ganglioneuroma is a rare benign tumor, which is usually located in the posterior mediastinum and retroperitoneum. Occasionally, it involves the paraspinal region with intraspinal extension and becomes dumbbell shaped. Dumbbell ganglioneuromas rarely affect the lumbar spine, and only nine cases of dumbbell lumbar ganglioneuromas have been reported previously. Case presentation: We are reporting an extremely rare case of a giant dumbbell tumor in the lumbar spine. We performed a one stage total resection of the tumor with posterior approach and long-segment fixation and fusion. This approach is different from previous methods. Histopathological examination of the surgical specimen confirmed the diagnosis of ganglioneuroma. Thirty months follow up showed a satisfactory outcome. Conclusions: Single-stage posterior tumor resection with fixation and fusion is effective and an appropriate choice for the treatments of lumbar dumbbell ganglioneuromas.

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Giant ganglioneuroma of the posterior mediastinum

Cited by 22 publications

References 9 publications

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Posterior mediastinal ganglioneuroma:A case report and literature review

Single stage complete resection of giant dumbbell lumbar ganglioneuroma: a case report and review of the literature

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