Giant fennel (<i>Ferula communis</i> L) intoxication in goats in Tunisia

Lahmar, Rym; Mahjoub, Tarek; Fourel, Isabelle; Gault, G.; Grancher, Denis

doi:10.1136/vetreccr-2018-000738

Cited by 5 publications

(9 citation statements)

References 8 publications

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“…The present study exhibited the fetotoxicity of F. communis extracts that caused histopathological alterations in the livers of mothers and their embryos. F. communis is reported as a poisonous plant to man and animals; that is goat intoxication was documented in Tunisia (Shlosberg and Egyed, 1983; Lahmar et al, 2018). The toxicity of F. communis was documented, that is, hemorrhage, general pain, teratogenic effects , abortion, irritation, and neurotoxicity (Shlosberg and Egyed, 1983; Kharchoufa et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Effects of silver nanoparticles prepared by aqueous extract of Ferula communis on the developing mouse embryo after maternal exposure

Seleem,

Hussein

2023

Toxicol Ind Health

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Green synthesis of silver nanoparticles (AgNPs) from aqueous silver nitrate has been achieved using an extract of Ferula communis leaf as a capping, reducing, and stabilizing agent. The formation and stability of the green synthesized silver nanoparticles in the colloidal solution were monitored by absorption measurements. Silver nanoparticles were characterized by different analyses such as X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), and FT-IR spectroscopy. The average particle size of silver nanoparticles was determined by high-resolution transmission electron microscopy (HRTEM) and scanning electron microscopy (SEM) analyses. In this experiment, pregnant female mice were divided into four groups (G); G1 was the control and received phosphate-buffered saline, G2 received orally aqueous extract of F. communis leaf , G3 received orally AgNPs chemically prepared by NaBH4, and G4 received orally AgNPs prepared by aqueous extract of F. communis leaf . The diameter of AgNPs was 20 nm. AgNPs exhibited good catalytic reduction ability toward methyl orange in the presence of sodium borohydride with a rate constant of 2.95 x 10−4 s−1. The results revealed the occurrence of resorbed embryos in G2, G3, and G4 with different percentages. The livers of mothers and embryos at E14.5 in G2, G3, and G4 showed different levels of histopathological alteration and increase in GFAP and CTGF expressions compared with the control group. The study concluded that the oral administration of small-sized AgNPs (20 nm) prepared by Ferula extract had less toxicity than those prepared by the chemical method.

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Section: Discussionmentioning

confidence: 99%

Effects of silver nanoparticles prepared by aqueous extract of Ferula communis on the developing mouse embryo after maternal exposure

Seleem,

Hussein

2023

Toxicol Ind Health

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“…The toxic variety is considered to be responsible for a lethal haemorrhagic syndrome which is also called ferulosis [ 22 ]. This intoxication can affect sheep ( Ovis aries ), goats ( Capra aegagrus hircus ), cattle ( Bos Taurus ) and horses ( Equus caballus ) [ 23 , 26 , 27 ].…”

Section: Haemorrhagic Disordersmentioning

confidence: 99%

“…This haemorrhagic syndrome is evidenced by the presence of bleeding from the nostrils or even blood in stools. Pale mucous membranes, muscle weakness, arrhythmias, shallow breathing and even death, may be associated with this syndrome [ 12 , 26 , 27 ]. Clinical signs appear within 24–48 h after consuming the plant [ 12 ].…”

Section: Haemorrhagic Disordersmentioning

confidence: 99%

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Anaemia in Ruminants Caused by Plant Consumption

Lacasta

Ramos

Quintas

et al. 2022

Animals

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Plant toxicology has affected animals throughout evolution. Plants have adapted themselves to the environment. This adaptation has led to the development of defensive strategies to avoid being consumed. Plants have several chemical compounds, which can cause deleterious effects on people or animals that consume them, causing a wide variety of clinical signs. Plants from various latitudes, both cultivated for human and animal feeding or decorative purpose and even wild growth plants are able to generate anaemia in ruminants. Coumarins or ptaquiloside predispose bleeding and haemorrhages, causing a haemorrhagic disease in affected animals. In this group, some important fodder plants, such sweet clover (Genus Melilotus spp.), or other weeds distributed worldwide, such as bracken fern (Pteridium aquilinum) of giant fennel (Ferula communis), are included. On the other hand, sulfur-containing chemicals (e.g., n-propyl disulfate and S-propyl cysteine sulfoxides (SMCOs)) may cause severe direct damage to the erythrocyte and their membrane, leading to their destruction and causing haemolytic anaemia in the animal. This review presents the most frequent intoxication by plants causing anaemia in ruminants. Toxic compounds, clinical signs, diagnosis and possible treatments are also presented.

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“…Livestock can also be exposed and intoxicated to natural anti-vitamin K like dicoumarol after the ingestion of moldy clover fodder ( 40 , 41 ) or like ferprenin and ferulenol after giant fennel intake ( 42 , 43 ).…”

Section: Anticoagulant Rodenticides Use and Propertiesmentioning

confidence: 99%

Biomarkers Potency to Monitor Non-target Fauna Poisoning by Anticoagulant Rodenticides

et al. 2020

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The widespread use of pesticides to control agricultural pests is a hot topic on the public scene of environmental health. Selective pest control for minimum environmental impact is a major goal of the environmental toxicology field, notably to avoid unintended poisoning in different organisms. Anticoagulant rodenticides cause abnormal blood coagulation process; they have been widely used to control rodents, allowing inadvertent primary and secondary exposure in domestic animals and non-target predatory wildlife species through direct ingestion of rodenticide-containing bait or by consumption of poisoned prey. To report toxic effect, the most common approach is the measurement of liver or plasma residues of anticoagulant rodenticides in dead or intoxicated animals showing clinical symptoms. However, one major challenge is that literature currently lacks a hepatic or plasma concentration threshold value for the differentiation of exposure from toxicity. Regarding the variation in pharmacology properties of anticoagulant rodenticides inter- and intra-species, the dose-response relationship must be defined for each species to prejudge the relative risk of poisoning. Beyond that, biomarkers are a key solution widely used for ecological risk assessment of contaminants. Since anticoagulant rodenticides (AR) have toxic effects at the biochemical level, biomarkers can serve as indicators of toxic exposure. In this sense, toxicological knowledge of anticoagulant rodenticides within organisms is an important tool for defining sensitive, specific, and suitable biomarkers. In this review, we provide an overview of the toxicodynamic and toxicokinetic parameters of anticoagulant rodenticides in different animal species. We examine different types of biomarkers used to characterize and differentiate the exposure and toxic effects of anticoagulant rodenticide, showing the strengths and weaknesses of the assays. Finally, we describe possible new biomarkers and highlight their capabilities.

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Giant fennel (Ferula communis L) intoxication in goats in Tunisia

Cited by 5 publications

References 8 publications

Effects of silver nanoparticles prepared by aqueous extract of Ferula communis on the developing mouse embryo after maternal exposure

Effects of silver nanoparticles prepared by aqueous extract of Ferula communis on the developing mouse embryo after maternal exposure

Anaemia in Ruminants Caused by Plant Consumption

Biomarkers Potency to Monitor Non-target Fauna Poisoning by Anticoagulant Rodenticides

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