Lipomas are tumors which grow into primary mesenchymal tumors. They develop in areas of abundant adipose tissue. Lipomas represent 4 to 5% of all benign tumors' in the body. If a Lipoma exceeds at least 10 cm in one dimension or weighs a minimum of 1000 grams, it is considered to be a giant lipoma. We report a case of a 55-year-old female. She was operated for left lipoma breast weighing 12.5 kg. This is probably the largest lipoma of breast reported in the literature. Postoperative recovery of the patient was uneventful. The case prompted this report because of its challenging size, location, diagnosis, and reconstructive solution.