Giant esophageal squamous papilloma: a case report

Tabatabaei, Sayed Abbas; Moghadam, Noshin Afshar; Ahmadinejad, Mojtaba; Mirmohammadsadeghi, Amir; Masoudpour, Hassan; Adibi, Peyman

doi:10.1111/j.1751-2980.2009.00390.x

Cited by 14 publications

(12 citation statements)

References 13 publications

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“…9 Giant squamous papillomas are known to occur and can present with symptoms, like dysphagia, coughing, and so on. 10 During endoscopy, squamous papilloma often shows a single, small (usually ,0.5 cm), whitish, and elevated sessile lesion or with vessels crossing on a wart-like surface. 3 Endoscopic appearance is usually characteristic but not pathognomonic.…”

Section: Squamous Papillomamentioning

confidence: 99%

Squamous Neoplasia in the Esophagus

Savant

Zhang

Yang

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Squamous lesions of the esophagus encompass a spectrum of disorders ranging from reactive changes and benign papilloma to squamous dysplasia and squamous cell carcinoma, which may pose diagnostic challenges especially in superficial biopsies. Objective.— To provide a review on the typical features of squamous neoplasia in the esophagus, with an emphasis on the key diagnostic features as well as differential diagnosis from mimicking lesions. Data Sources.— Data sources include published peer-reviewed literature and personal experiences of the authors. Conclusions.— Accurate diagnosis of squamous neoplasia requires adherence to established diagnostic criteria, attention to subtle histologic features, and correlation with clinical and imaging findings. In difficult cases, multiple biopsies may be necessary to reach a definitive diagnosis.

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Section: Squamous Papillomamentioning

confidence: 99%

Squamous Neoplasia in the Esophagus

Savant

Zhang

Yang

2020

Archives of Pathology &Amp; Laboratory Medicine

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“…Its macroscopic appearance is similar to other, less benign growths (verrucous squamous cell carcinoma, granulation tissue, or papillary leukoplakia). Other differential considerations should include fibrovascular polyp, inflammatory fibroid polyp, leiomyoma, and malignant melanoma [10]. Narrow band imaging (NBI) can further evaluate a squamous papilloma during endoscopy as microvessels within the lesion will not be dilated [11].…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Papilloma of the Esophagus: A Case Series Highlighting Endoscopic and Histologic Features

Uhlenhopp

Olson

Sunkara

2020

Case Reports in Gastrointestinal Medicine

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Esophageal squamous papillomas are rare epithelial lesions typically discovered incidentally during EGD. Their prevalence is estimated to be less than 0.01% in the general population. We present three cases of esophageal squamous papillomas identified histologically. It may be possible to identify these lesions macroscopically. One study provided a positive predictive value of 88% for squamous papilloma utilizing the triad of exophytic growth, wart-like projections, and surface vessel crossing seen on narrow band imaging during endoscopy. The etiology is unclear. Chronic mucosal irritation from GERD or esophagitis is the prevailing theory of pathogenesis, but HPV has been detected in some lesions. The malignant potential of these lesions is considered controversial. There are documented cases demonstrating complications with squamous cell carcinoma, so we recommend removal of all esophageal squamous papillomas; however, the small absolute number of cases documented in the literature makes drawing any associations or conclusions between esophageal squamous papillomas and squamous cell carcinoma difficult. Further research is needed regarding treatment and surveillance. This case series helps contribute to the small but growing literature of this rare finding.

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“…Squamous papillomas are typically reported as fleshy-pink in colour, with a soft to warty texture and exist in either sessile or pedunculated form. While the typical endoscopic appearance is a single, round sessile lesion, they can present with multiple esophageal lesions, with rare reports of papillomas exceeding 1 cm in diameter (4). Histologically, they are characterized by vascular connective tissue stalks branching out from the lamina propria with an overlying hyperplastic squamous epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…The management of esophageal papillomatosis has not been clearly defined in the literature. Small isolated lesions have been successfully treated with endoscopic resection using biopsy forceps, snare polypectomy and cautery (4). The management of multiple esophageal lesions can be more challenging and, due to the paucity of reported cases, the optimal clinical management of extensive papillomatosis remains unclear.…”

Section: Images Of the Monthmentioning

confidence: 99%

Endoscopic Mucosal Resection of Esophageal Squamous Papillomatosis

Kim

Byrne

Donnellan

2012

Canadian Journal of Gastroenterology

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A 62-year-old woman was referred for investigation of heartburn. She did not have any other significant medical history and denied any other symptoms including weight loss, dysphagia, odynophagia, regurgitation and hematemesis. Her only medication was pantoprazole 40 mg daily for her gastroesophageal reflux disease. Endoscopy was performed with a GIF-Q180 gastroscope (Olympus Optical, Japan), which demonstrated multiple flesh-coloured pedunculated papules at the gastroesophageal junction (Figure 1). Biopsies demonstrating atypical epithelial proliferation confirmed the diagnosis of esophageal squamous papillomatosis, without the presence of dysplasia or carcinoma. A polymerase chain reaction study was negative for herpes simplex virus. Following discussion with the patient, an extensive endoscopic mucosal resection (EMR) incorporating all of the lesions was performed using a band mucosectomy device (Duette, Cook Medical, Ireland) (Figures 2 and 3). Histology from the EMR specimens was similar to the original mucosal biopsy results. No immediate or delayed complications occurred.

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Giant esophageal squamous papilloma: a case report

Cited by 14 publications

References 13 publications

Squamous Neoplasia in the Esophagus

Squamous Neoplasia in the Esophagus

Squamous Cell Papilloma of the Esophagus: A Case Series Highlighting Endoscopic and Histologic Features

Endoscopic Mucosal Resection of Esophageal Squamous Papillomatosis

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