Giant cranial and cerebellar hemangioma treated with propranolol

Benvenisti, Haggai; Ben-Sira, Liat; Constantini, Shlomi; Roth, Jonathan

doi:10.1007/s00381-014-2603-4

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…Surgical resection was performed in most of the cases. Other treatment options are propranolol [17], and systemic corticoids [18]. Thalidomide has been anecdotally reported as a treatment in cases of unresectable lesions [19], but never in infants.…”

Section: Discussionmentioning

confidence: 99%

Giant Congenital Hemangioma of the Skull: Prenatal Diagnosis and Multimodal Endovascular and Surgical Management

Alexandre,

Romi,

Gaudino

et al. 2024

Medicina

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Introduction: calvarial capillary hemangiomas are vascular tumors rarely seen in newborns. Differential diagnosis may be not straightforward on imaging studies and the management depends on patient and lesion characteristics. Case report: we present the case of a large congenital intracranial extra-axial lesion detected by routine prenatal US screening, a giant calvarial congenital hemangioma, treated with a multimodal strategy. Neonatal MR showed a hemorrhagic solid lesion, causing compression of brain tissue. Conservative treatment was attempted, but a one-month follow-up MR showed growth of the lesion with increased mass effect. Pre-operative endovascular embolization and surgical resection were performed. The pathology was consistent with intraosseous capillary hemangioma. The post-operative course was uneventful. At the 8-month follow-up, the patient had no clinical deficits and MR showed complete resection of the lesion. At the 13-month follow-up, the patient was asymptomatic, showing normal neurological examination and psychophysical development. Conclusions: although wait-and-see policy is feasible for small and asymptomatic lesions, radical resection is indicated when the mass is large, thus causing severe mass effect on the brain. Hypervascularization of the tumor may be responsible for hemorrhagic complications and severe anemia. On these grounds, endovascular treatment is feasible and effective to reduce hemorrhagic complications.

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Section: Discussionmentioning

confidence: 99%

Giant Congenital Hemangioma of the Skull: Prenatal Diagnosis and Multimodal Endovascular and Surgical Management

Alexandre,

Romi,

Gaudino

et al. 2024

Medicina

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“…We identified 41 cases of reported intracranial infantile hemangioma in the literature ( Table 1 ) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. The majority of patients were female (68%).…”

Section: Discussionmentioning

confidence: 99%

“…Five cases of intracranial infantile hemangioma successfully treated with oral propranolol have been reported since then. In four cases, there was complete resolution of the intracranial hemangioma [ 6 , 8 , 16 ], and there was a reduction in lesion size in the final case [ 28 ]. No adverse effects were encountered.…”

Section: Discussionmentioning

confidence: 99%

“…This report was reviewed by the Oxford University Hospitals’ ethics team and formal ethical approval was deemed not to be required. We performed a literature review using Pubmed, searching for keywords “intracranial infantile hemangioma/s”, and identified 41 reported cases ( Table 1 ) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. There was no uniform treatment approach observed.…”

Section: Introductionmentioning

confidence: 99%

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Safe and Effective Treatment of Intracranial Infantile Hemangiomas with Beta-Blockers

2021

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Infantile hemangiomas are common benign vascular tumors but are rarely found in an intracranial location. Our literature review identified 41 reported cases. There is no general consensus on management of these rare lesions and until recently, treatment was limited to surgery or pharmacological management with steroids or interferon. Although beta-blockers have been widely prescribed in the treatment of cutaneous infantile hemangiomas since 2008, their use in the treatment of intracranial infantile hemangiomas has been minimal. We present a case of infantile hemangioma affecting the right orbit, associated with intracranial extension, causing intermittent right facial nerve palsy. The patient achieved an excellent outcome following combined treatment with oral propranolol and topical timolol maleate 0.5%, with complete regression of the lesion by 4 months. We conclude that beta-blockers are a safe and effective treatment of intracranial infantile hemangiomas and can be employed as first-line management of these lesions.

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Infantile Hemangiomas of the Central Nervous System

Winograd

Reynolds

et al. 2021

Pediatric Vascular Neurosurgery

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Giant cranial and cerebellar hemangioma treated with propranolol

Abstract: Propranolol is a valid treatment for large cranial hemangiomas, avoiding the risks involved in surgeries.

Cited by 8 publications

References 13 publications

Giant Congenital Hemangioma of the Skull: Prenatal Diagnosis and Multimodal Endovascular and Surgical Management

Giant Congenital Hemangioma of the Skull: Prenatal Diagnosis and Multimodal Endovascular and Surgical Management

Safe and Effective Treatment of Intracranial Infantile Hemangiomas with Beta-Blockers

Infantile Hemangiomas of the Central Nervous System

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