Giant condyloma (Buschke—Loewenstein tumor) of the anorectum

Elliot, M. S.; Werner, I. D.; Immelman, E. J.; Harrison, A. C.

doi:10.1007/bf02586940

Cited by 28 publications

(10 citation statements)

References 11 publications

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“…Any compromise regarding radicality predisposes to local recurrence within a short period after the operation [4][5][6]8]. Patients with extensive lesions, especially those with multiple fistulous tracts and purulent discharge, may require a temporary loop colostomy.…”

Section: Discussionmentioning

confidence: 99%

Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-L�wenstein tumor)

Bertram

Treutner

Rübben³

et al. 1995

Langenbecks Arch Chir

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Giant condyloma acuminata, first described by Buschke and Löwenstein in 1925 as a penile lesion, is extremely rare in the anorectal region. The cauliflower-like tumor behaves clinically in a malignant fashion, although it shows no histomorphological criteria of malignancy. Up to the time of writing only 33 cases of anorectal origin, 42% with malignant transformation, have been published. The authors report 2 more cases of squamous-cell carcinoma in giant anorectal condylomata acuminata. Buschke-Löwenstein tumor is an intermediate entity between "ordinary" condyloma acuminata and squamous-cell carcinoma. Benign condyloma acuminata is caused by human papillomavirus 6 or 11. Carcinogenic cofactors promote the transition to giant, locally destructive condyloma acuminata and subsequent malignant transformation. Cure can only be achieved by early and radical excision. Formation of multiple fistulas and destruction of the sphincter may necessitate abdomino-perineal resection. Adjuvant radiation therapy should only be considered to render a tumor operable, as radiation may act as a cocarcinogenic effect and lead to a less differentiated and more aggressive cancer. The small number of cases reported and the variety of treatment regimens applied, however, do not allow the formulation of definitive therapeutic guidelines.

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Section: Discussionmentioning

confidence: 99%

Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-L�wenstein tumor)

Bertram

Treutner

Rübben³

et al. 1995

Langenbecks Arch Chir

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“…In patients with BLT with suspicion of malignant transformation, the optimal treatment is not well defined. Some authors recommend preoperative chemoradiotherapy to downstage extensive tumors, followed by radical surgery [24]. Tytherleigh et al .…”

Section: Discussionmentioning

confidence: 99%

Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke–Löwenstein tumor): a case report and review of the literature

et al. 2013

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IntroductionVerrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential.Case presentationWe report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke–Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later.ConclusionsThe purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management.

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“…6,10 These cases, however, form the exception and not the rule. In some cases, additional employment of fulguration, 11 fecal diversion, 12 or interferon 13 as an initial form of therapy has been described with varying results regarding disease recurrence. [11][12][13] When disease recurrence was observed, diathermy 6 or repeated simple excisions, 14 wide local excision, 15 or radiation therapy 16 were applied.…”

Section: Surgical Modalitiesmentioning

confidence: 99%

Surgical Management of Giant Condyloma Acuminatum (Buschke-Loewenstein Tumor) of the Perianal Region

et al. 2007

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Giant condyloma (Buschke—Loewenstein tumor) of the anorectum

Cited by 28 publications

References 11 publications

Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-L�wenstein tumor)

Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-L�wenstein tumor)

Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke–Löwenstein tumor): a case report and review of the literature

Surgical Management of Giant Condyloma Acuminatum (Buschke-Loewenstein Tumor) of the Perianal Region

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