Giant cell tumours in mandible and spine: a rare complication of Paget's disease of bone.

Abstract

The case of a man who was diagnosed as

Evidence for Increased Clinical Severity of Familial and Sporadic Paget's Disease of Bone in Campania, Southern Italy

“…(17–19 On the other hand, patients with sporadic PDB from this geographical area also showed a higher prevalence of this neoplasm, which in patients with PDB shows peculiar clinical characteristics. (29–31 Indeed, classic giant cell tumors affect patients between 20 and 40 years of age, whereas tumors in pagetic bones occur in patients older than 50 years. Moreover, in patients with PDB, giant cell tumor preferentially involves craniofacial and vertebral bones.…”

“…(36 The evidence that neoplastic degeneration in pagetic patients from Campania occurs even if they have lived for several years in other countries or continents suggests environmental factors in the pathogenesis of this phenomenon. (17,18,29,30 On the other hand, considering the possible viral etiology of PDB and the considerably low prevalence of anti‐paramixovirus vaccination in Campania, an epistemological interaction between genetic and viral factors in the pathogenesis and clinical manifestations of disease cannot be excluded. (37 Moreover, the analysis of lifestyle and dietary habits of patients recruited in this study showed some environmental differences with a greater use of unpasteurized milk and of fresh, homemade meat products without sanitary control in the group of patients from Campania with PDB with respect to patients with PDB from other geographical areas.…”

Benign Fibro-Osseous Lesions of the Craniofacial Complex A Review

“…Giant cell tumors are histologically identical with giant cell granulomas of the jaws and giant cell tumor of long bones [69,70]. In the craniofacial complex they appear as multilocular radiolucencies on plane films or as multicompartmentalized lesions on CT images.…”

Paget Sarcoma of the Spine: Scottish Bone Tumor Registry Experience

“…5-10 Giant cell tumor in association with vertebral Paget disease has been documented. 34 We found two cases of giant cell variant of osteosarcoma. The authors recall the rarity of nonosteogenic sarcomatous degeneration of lesions of the spine caused by Paget disease; osteosarcoma made up the majority of the current series.…”