Giant cell tumors of bone localized in distal radius

Atalay, İsmail Burak

doi:10.4328/acam.20011

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Local tumor control is difficult because of GCT's aggressive behavior. In some patients, functional statuses of joints and bones have to be sacrificed 21 , 22 . Recurrence rates of GCTs are highly controversial and major factors are about surgical technique.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio patients with giant cell tumor of bone

Yapar¹,

Atalay²,

Tokgöz³

et al. 2021

Afr H. Sci.

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Objective: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in giant cell tumor of bone (GCT). Methods: The patients with GCT were identified in the hospital records and pre-treatment complete blood count results were acquired retrospectively. Whether preoperative NLR lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) values had prognostic significance in predicting recurrence was evaluated by Receiver operating curve (ROC) analysis. Furthermore, the prognostic value of NLR was evaluated by Multivariable Cox Regression analysis. Results: There were 96 patients with GCT. It was found that only NLR values had prognostic significance for predicting recurrence (AUC:0.647; 95% CI:0.533-0.762; P=0.021). The statistically significant cut-off value of NLR for predicting re- currence was ≥2.25.NLR was ≥2.25 in 51% (n = 49) of patients. Multivariable analysis showed that NLR ≥2.25 (HR=2.9, 95% CI:1.3-6.6; p=0.009) and lung metastasis (HR=7.9, 95% CI:2.2-28.2; p=0.001) were independent factors of recurrence. In patients with lung metastasis and patients with NLR ≥2.25, recurrence was observed in a sooner period (Log rank test; p=0.001; p=0.009, respectively). Conclusion: Our findings showed that NLR is a new and promising inflammation-based prognostic factor in GCT patients. Keywords: Giant cell tumor of bone; neutrophil-to-lymphocyte ratio; prognostic significance.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio patients with giant cell tumor of bone

Yapar¹,

Atalay²,

Tokgöz³

et al. 2021

Afr H. Sci.

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“…It is slightly more common in women than in men. [3,4] In general, it constitutes 5% of all bone tumors. [5] It is most commonly located in distal femur, proximal tibia, and distal radius.…”

Section: Introductionmentioning

confidence: 99%

Kemiğin dev hücreli tümörlerinde rekürrens ve akciğer metastazı arasındaki ilişki

Yapar

Atalay

Ulucaköy

et al. 2020

Turkish Journal of Clinics and Laboratory

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Aim:The aim of this study is to evaluate the relationship between recurrence and lung metastasis in patients diagnosed with giant cell tumor of bone treated in our clinic and to present the other factors affecting the recurrence. Material and Methods:The patients who were treated and followed up for a giant cell tumor of the bone between 2002 and 2018 were retrospectively reviewed. A total of 114 patients with a mean age of 31.6 ± 13.3 were included in the study. Results:The mean follow-up period was 63.1 ± 33.4 months. Recurrence occurred in 26.3% (30 patients) of the patients in a mean of 17.1 months, while metastasis in the lung was found in 4.4% (5 patients). When the patients were evaluated according to their recurrence status, lung metastasis was observed in 13.3% of the patients with recurrence, while lung metastasis was observed in 1.2% of the patients without recurrence. Lung metastasis was found to be significantly higher in patients with recurrence than in the group without recurrence (p = 0.017). For lung metastasis, Hazard Ratio (HR) was calculated as 12.8 (95% CI: 1.4-119.5; p = 0.026). Conclusion:Giant cell tumors of the bone are locally aggressive tumors with unpredictable behavior. In our study, when the patients were evaluated according to their recurrence status, lung metastasis was observed in 13.3% of the patients with recurrence, and 1.2% of the patients without recurrence. Lung metastasis was found to be significantly higher in patients with recurrence than in the group without recurrence.

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Giant cell tumors of bone localized in distal radius

Cited by 2 publications

References 13 publications

Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio patients with giant cell tumor of bone

Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio patients with giant cell tumor of bone

Kemiğin dev hücreli tümörlerinde rekürrens ve akciğer metastazı arasındaki ilişki

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