Giant Cell Tumor of the Orbit

Abstract

Giant cell tumors of the skull are very rare and usually occur in the sphenoid bone. The authors report the case of a 10-year-old boy with such a tumor involving exclusively the roof of the left orbit. He presented essentially with edema of the left superior eyelid and diplopia. Computed tomographic examination and magnetic resonance imaging delineated the lesion, which was radically removed via a left fronto-orbital craniotomy. Some aspects of this rare neoplasm are reviewed.

Giant-Cell Tumors of the Sphenoid Bone in Four Children: Radiological, Clinical, and Pathological Findings

“…On cross section, some areas of yellowish discoloration may be present, which is secondary to lipid accumulation in histiocytes. 27 On histopathological examination, the tumor is composed of osteoclastic giant cells that are evenly distributed throughout the tumor tissue. The giant cells contain a variable amount of nuclei with an average of about 10 to 30 nuclei in most cases.…”

Giant cell tumor of the clivus with presence of epithelioid histiocytes

“…[9] Skull X-rays and angiography have been the traditional investigations for the diagnosis of the GCTs of the skull. [39] Recently, computed tomography (CT) and MRI have been increasingly used for the diagnosis of these lesions, and the CT appearance of GCT is that of a homogeneous hyperdense mass highly enhancing after contrast administration. [211] Bony erosions can also be demonstrated by CT scan examination,[311] and the bone adjacent the lesion can appear hyperplastic in some cases.…”

“…[39] Recently, computed tomography (CT) and MRI have been increasingly used for the diagnosis of these lesions, and the CT appearance of GCT is that of a homogeneous hyperdense mass highly enhancing after contrast administration. [211] Bony erosions can also be demonstrated by CT scan examination,[311] and the bone adjacent the lesion can appear hyperplastic in some cases. [12] The treatment of choice of GCTs is complete surgical excision and if it can be achieved it is curative; however, as was seen in the present case, it is may not always be feasible.…”

“…[3] In the present article, we report a case of GCT of the clivus and review the relevant literature.…”

Tumores benignos e lesões pseudotumorais do crânio: Aspectos clínicos e radiológicos

“…O aspecto radiopaco e esclerótico é observado em osteoma, fibroma ossificante e osteocondroma 8,13,28,49,53,55,58,60,73,74 . O aspecto radiotransparente é observado em granuloma eosinofílico, hemangioma, cisto ósseo aneurismático, condroblastoma, osteoblastoma e tumor de células gigantes 3,4,12,16,17,21,23,31,35,58,59,63,64,65,66,68,78,81,84 . No granuloma eosinofílico, podemos ter a presença de calcificação central dando o aspecto de "olho de boi" (bull eye) 16,23,48,57,59,78 .…”