Giant-Cell Tumor of the Tendon Sheath in the Upper Cervical Spine

Teixeira, William Gemio Jacobsen; Lara, Nilton Alves; Narazaki, Douglas Kenji; Oliveira, Cláudia de; Cavalcanti, Conrado Furtado de Albuquerque; Marins, Lidiane V.; Cristante, Alexandre Fogaça; Teixeira, Manoel Jacobsen; Filho, Tarcísio Eloy de Barros

doi:10.1200/jco.2011.36.7482

Cited by 16 publications

(9 citation statements)

References 19 publications

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“…It is similar with the rate of appendicular PVNS reported in different studies (0-50%)14,17,23,34). Various treatments for PVNS include surgery, radiation therapy, radioisotope infusions, and chemotherapy8,21,22,33,48). Surgical excision with the aim of gross total resection is accepted as the treatment of choice.…”

Section: Discussionmentioning

confidence: 99%

Pigmented Villonodular Synovitis on Lumbar Spine : A Case Report and Literature Review

Lee

Eoh

2014

J Korean Neurosurg Soc

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Pigmented villonodular synovitis (PVNS) is a benign proliferative joint disease with an uncertain etiology that uncommonly involves the spine. We present a case of PVNS involving the lumbar spine. A 38-year-old male developed back pain and pain in both legs caused by a mass in the L4 region of the right lamina. After gross total tumor removal, the symptoms improved. The pathological finding was synovial hyperplasia with accumulation of hemosiderin-laden macrophages. He was diagnosed with PVNS and experienced no recurrence for up to 2 years after surgery. In this report, we review the previous literature and discuss etiology, clinical manifestations, diagnosis, and treatment.

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Section: Discussionmentioning

confidence: 99%

Pigmented Villonodular Synovitis on Lumbar Spine : A Case Report and Literature Review

Lee

Eoh

2014

J Korean Neurosurg Soc

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“…There were 29 men and 40 women (the gender was unavailable in 1 case) (46), and the male to female ratio was 1:1.38. The …”

Section: Meta-analysismentioning

confidence: 99%

Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature

Wang

Zhu²,

Yang³

et al. 2014

Turkish Neurosurgery

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Three patients with spinal primary diffuse-type tenosynovial giant cell tumor (DTGCT) received surgical treatment in our department between 2002 and 2012. All 3 patients were female and aged 23, 33, and 44 years. The mean time from symptom onset to diagnosis was 17 months (range, 5-24 months). One case involved the C1 right lateral mass and C2 vertebral body, the second involved the C1-2 left lateral masses and C2 vertebral body, and the third involved the C5-7 left lateral mass and C6 vertebral body. All patients underwent computed tomographyguided biopsy to confirm the diagnosis of tenosynovial giant cell tumor. Gross total resection was achieved in all patients, including 2 piecemeal resections and 1 en-bloc resection. The mean follow-up time was 6 years (range, 1-11 years), and there was no sign of recurrence in the patients. Seventy cases have been identified so far in the English literature. The male to female ratio is 1:1.38. The mean patient age is 38.5 ± 17.9 years. The tumor distribution includes 32 cases in the cervical spine, 14 in the thoracic spine, 22 in the lumbar spine, and 1 in the sacrococcygeal region. The recurrence rate for patients who underwent gross total resection was 7.7%, and tumor progression was observed in 66.7% of patients who underwent subtotal resection. Above all, DTGCT is a rare primary spinal neoplasm. Preoperative image-guided biopsies play an important role in the diagnosis and treatment strategy. Gross total resection is the best treatment strategy and can reduce the recurrence rate. (aralık, 5-24 ay). Bir olguda C1 sağ lateral kitle ve C2 vertebral cisim tutulması vardı. İkinci olguda C1-2 sol lateral kitleleri ve C2 vertebra cismi tutulmuştu. Üçüncü olguda C5-7 sol lateral kitleleri ve C6 vertebra cismi tutulmuştu. Tüm hastalarda tenosinov yal dev hücreli tümör tanısını doğrulamak için bilgisayarlı tomografi kılavuzluğunda biyopsi yapıldı. Tüm hastalarda gros total rezeksiyon yapıldı. Hastaların ikisinde parça parça ve 1'inde ise en blok halinde rezeksiyon ile gerçekleştirildi. Ortalama takip süresi 6 yıldı (aralık, 1-11 yıl) ve hastalarda bir nüks bulgusu yoktu. İngilizce literatür-de şimdiye kadar 70 olgu tanımlanmıştır. Erkek/kadın oranı 1:1,38'dir. Ortalama hasta yaşı 38,5 ± 17,9 yıldır. Tümör dağılımı servikal omurgada 32 olgu, torasik omurgada 14 olgu, lomber omurgada 22 olgu ve sakrokoksigiyal bölgede 1 olgu şeklindedir. Gros total rezeksiyon yapılan hastalarda nüks oranı %7,7 bulunmuş ve subtotal rezeksiyon yapılan hastaların %66,7'sinde tümör ilerlemesi gözlenmiştir. Genel olarak DTGCT nadir bir primer spinal neoplazmdır. Preoperatif tomografi kılavuzluğunda biyopsiler, tanı ve tedavi stratejisinde önemli bir rol oynamaktadır. En iyi tedavi gros total rezeksiyondur.

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“…The signals on T2WI were mostly isointense to hypointense because of the paramagnetic effect of haemosiderin. On gradientecho sequences, this finding is more obvious because of blooming artifacts [7][8][9]. The signals on T2WI can also be variable, depending on mass components, which may have variable haemosiderin, liquid, lipid, and fibrous tissue contents and haemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Giant cell tumour of the tendon sheath of the spine: clinical features and imaging findings

et al. 2021

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Objectives To review the clinical and imaging data of spinal giant cell tumour of the tendon sheath (GCTTS) to improve our understanding of the disease. Methods The imaging findings, clinicopathological features and clinical outcomes of 14 patients with pathologically confirmed spinal GCTTS were analysed retrospectively. Results All 14 patients had a single spinal lesion, including ten cervical vertebra lesions and four thoracic vertebra lesions. CT scan findings: The lesions showed osteolytic bone destruction and were centred on the facet joint, eroding the surrounding bone with a paravertebral soft tissue mass. MRI scan findings: all the lesions manifested predominantly as isointense or hypointense on T1-weighted imaging (T1WI). On T2-weighted imaging (T2WI), eight lesions were hypointense, and four were isointense. The remaining two lesions showed slight hyperintensity. The enhanced scans of eight lesions showed moderate to marked homogeneous or heterogeneous enhancement. PET/CT findings: Among the five patients who underwent PET/CT, three presented lesions with well-defined, sclerotic borders, and the uptake of 18F-FDG was markedly increased. One lesion showed an ill-defined border and an uneven increase in 18F-FDG uptake with an SUVmax value of 8.9. A recurrent lesion was only found on PET/CT 45 months after surgery and the SUVmax was 5.1. Conclusions Spinal GCTTS is extremely rare. Osteolytic bone destruction in the area of the facet joint with a soft tissue mass and hypointensity on T2WI images are indicative of the spinal GCTTS. GCTTS shows high uptake of 18F-FDG, and PET/CT is helpful in detecting recurrent lesions.

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Giant-Cell Tumor of the Tendon Sheath in the Upper Cervical Spine

Cited by 16 publications

References 19 publications

Pigmented Villonodular Synovitis on Lumbar Spine : A Case Report and Literature Review

Pigmented Villonodular Synovitis on Lumbar Spine : A Case Report and Literature Review

Primary diffuse-type tenosynovial giant cell tumor of the spine: a report of 3 cases and systemic review of the literature

Giant cell tumour of the tendon sheath of the spine: clinical features and imaging findings

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