Giant Cell Tumor of the Extremity

Niu, Xiaohui; Zhang, Qing; Lin, Hui‐Yi; Ding, Yi; Li, Yuan; Xu, Hairong; Liu, Weifeng

doi:10.2106/jbjs.j.01922

Cited by 156 publications

(91 citation statements)

References 41 publications

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“…Indeed, the incidence was slightly higher than previously reported in the US (0.16 per million) 17. Notably, a higher incidence of GCTs in the Chinese population has been reported, ranging from 13.7 to 20 % of all bone tumors (benign and malignant) 16,18. In contrast, the incidence was only 5 % in other large-scale studies 16–18.…”

Section: Discussionmentioning

confidence: 63%

“…Notably, a higher incidence of GCTs in the Chinese population has been reported, ranging from 13.7 to 20 % of all bone tumors (benign and malignant) 16,18. In contrast, the incidence was only 5 % in other large-scale studies 16–18. When compared with all GCTs that most frequently occur in persons aged 20–40 years,16 malignant GCTs in the current study were more likely to occur in the elderly, and the incidence was consistent with previous reports that showed no gender predilection 17.…”

Section: Discussionmentioning

confidence: 99%

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Incidence Patterns of Primary Bone Cancer in Taiwan (2003–2010): A Population-Based Study

et al. 2014

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BackgroundPrimary bone cancer (BC) incidence by age has not been surveyed in Asia. MethodsThe incidence patterns of nine subtypes of primary BCs registered between 2003 and 2010 were analyzed from Taiwan cancer registry data. More specific analyses were conducted within age groups (Group I: 0–24 years; Group II: 25–59 years; and Group III: 60–85+ years). ResultsA total of 1,238 newly diagnosed subjects were registered with an age-standardized incidence rate (ASR) of 6.70 per million person-years. Overall, osteosarcoma (OS: 45 %) was the most common, followed by chondrosarcoma (CS: 18 %), and Ewing sarcoma (ES: 8 %). The percentages of cases and ASRs for age groups I, II, and III were 36.3, 43.0, and 20.7 %, and 7.00, 5.48, and 10.28 per million, respectively. Significant male predilections were observed for all BCs combined, and the CS, chordoma, and malignant ameloblastoma subtypes. Our findings demonstrated an upward trend of 4.8 % per year over the study period, and was more significant for females (6.7 %). A significant increase in trend existed in the incidence of BC among females in Group II, and the incidence of OS and ES among females in Group I.ConclusionsThis population-based study has allowed us to confidently define the incidence rates among three age groups of Taiwanese. Despite overall low rates, the upward trend in BC incidence among females may invoke a concern. The results suggest areas for further study into the underlying causes for these cancer trends.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Incidence Patterns of Primary Bone Cancer in Taiwan (2003–2010): A Population-Based Study

et al. 2014

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“…GCTB is one of the most widely investigated yet perplexing bone tumors. It accounts for 3–8% of primary bone tumors in Western countries; however, it is more common in Asia, where it accounts for approximately 20% of primary bone tumors234567. GCTB is most commonly diagnosed in individuals aged 20–40 years, and >50% of cases occur around the knee23891011.…”

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confidence: 99%

Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China

Zhao

Zhang

et al. 2016

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Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23.4%, but was higher in patients aged 20–39 years (28.5%; P = 0.039). The local recurrence rate was the highest in patients treated with intralesional curettage (53.4%), and the lowest in those treated with resection (4.9%). We found a higher risk of tumor recurrence in the proximal fibula compared to the distal femur (hazard ratio: 28.52, 95% confidence interval: 5.88–138.39; P < 0.0001), and in patients treated with curettage compared to those treated with resection (hazard ratio: 12.07, 95% confidence interval: 4.99–29.18; P < 0.0001). Thus, the tumor location must be considered when selecting the optimal surgical treatment approach to reduce the risk of local recurrence and preserve joint function, especially in young patients.

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“…Giant cell tumor of bone (GCTB) accounts for only 3–8% of primary bone tumors in Western populations, compared with 20% in Asian countries1234567. GCTB is particularly likely to occur around the knee (including the distal femur, proximal tibia, proximal fibula, and patella), accounting for >50% of cases23891011.…”

mentioning

confidence: 99%

“…Furthermore, a previous study conducted in China reported a 12.4% local recurrence rate in patients with primary GCTB located in an extremity6. However, all the patients collected in these previous reports were from a single institution and followed over a long time interval.…”

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Sex Differences in the Recurrence Rate and Risk Factors for Primary Giant Cell Tumors Around the Knee in China

Zhao

Zhang

et al. 2016

Sci Rep

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Although giant cell tumor of bone (GCTB) is more common in women in Western countries, it tends to be more common in men in Asian countries. We aimed to determine the sex differences in clinical characteristics, local recurrence rate, and relevant risk factors for local recurrence in primary GCTB around the knee. Between March 2000 and June 2014, patients with primary GCTB around the knee were recruited from 7 institutions in China, and 410 patients were included. The age at diagnosis was younger in women than in men (34.0 vs 37.2 years). The local recurrence rates were 23.4% overall, 25.8% in men, and 20.7% in women. Lower local recurrence rates were observed with en-bloc marginal resection in both men (6.9%) and women (3.1%). With tumors located in the distal femur, the local recurrence rate was higher for men than for women (29.1% vs 14.3%, P = 0.025). Local recurrence was significantly associated with the tumor location and surgical operation in men and only surgical operation in women. These findings suggest that more aggressive operations should be considered in men with GCTB in the proximal fibula.

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Giant Cell Tumor of the Extremity

Abstract: The incidence of giant cell tumor in the Chinese population may be higher than that in Western countries, and it has a male predilection. The results of the present study suggest that extensive curettage provides favorable local control and satisfactory functional outcomes.

Cited by 156 publications

References 41 publications

Incidence Patterns of Primary Bone Cancer in Taiwan (2003–2010): A Population-Based Study

Incidence Patterns of Primary Bone Cancer in Taiwan (2003–2010): A Population-Based Study

Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China

Sex Differences in the Recurrence Rate and Risk Factors for Primary Giant Cell Tumors Around the Knee in China

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