Giant cell tumor of the tendon sheath arising from a membrane surrounding the posterior arch of C1: a case report

Yamada, Shutaro; Oshima, Kazuya; Hamada, Kenichiro; Sotobori, Tsukasa; Joyama, Susumu; Hashimoto, Nobuyuki; Outani, Hidetatsu; Tanaka, Yoshikazu; Nakanishi, Katsuyuki; Araki, Nobuhito

doi:10.1016/j.spinee.2015.12.081

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…Some have emphasized the need to remove the entire synovium to prevent recurrence [ 5 ]. Giant cell tumors are radiosensitive, and radiation is generally recommended for subtotal resection; however, its role is controversial [ 9 , 10 ]. Due to the number of risk factors present for recurrence in this case, despite the gross total resection, postoperative radiation was planned should recurrence occur.…”

Section: Discussionmentioning

confidence: 99%

Tenosynovial Giant Cell Tumor of the Cervical Spine: Case Report and Review of the Literature

Thatikunta¹,

Nuru²,

Mathew³

et al. 2020

Cureus

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Section: Discussionmentioning

confidence: 99%

Tenosynovial Giant Cell Tumor of the Cervical Spine: Case Report and Review of the Literature

Thatikunta¹,

Nuru²,

Mathew³

et al. 2020

Cureus

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“…The most common origin of TGCTs has been reported to be the synovial membranes of the facet joints and bursa, depending on the location and growth characteristics, which can be classified as localized or diffused[ 6 ]. The diffuse type of TGCT affects the synovial membranes of large joints, such as the knees, hips, ankles, and elbows, while the localized type usually involves the tendons of the hands and feet[ 6 ]. TGCTs are also divided into intraarticular and extraarticular according to the site of growth.…”

Section: Discussionmentioning

confidence: 99%

Tenosynovial giant cell tumor involving the cervical spine: A case report

Zhu¹,

Li²,

Liang³

et al. 2021

WJCC

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BACKGROUND Tenosynovial giant cell tumors (TGCTs) are a frequent benign proliferative disease originating from the synovial membrane. However, TGCTs rarely occur in the spine. The purpose of this paper is to report a case of TGCT occurring in the cervical spine. Although the disease is rare, it is essential to consider the possibility of TGCT in axial skeletal lesions. Awareness of spinal TGCTs is important because their characteristics are similar to common spinal tumor lesions. CASE SUMMARY A 49-year-old man with a 2-year history of neck pain and weakness in both lower extremities was referred to our ward. Imaging revealed a mass extending from the left epidural space to the C4-5 paravertebral muscles with uneven enhancement. The tumor originated in the synovium of the C4-5 lesser joint and eroded mainly the C4-5 vertebral arch and spine. Puncture biopsy was suggestive of a giant cell-rich lesion. The patient had pulmonary tuberculosis, and we first administered anti-tuberculosis treatment. After the preoperative requirements of the anti-tuberculosis treatment were met, we used a posterior cervical approach to completely remove the mass after fixation with eight pedicle screws. The mass was identified as a TGCT by postoperative immunohistochemical analysis. Recurrence was not detected after 1 year of follow-up. CONCLUSION Spinal TGCTs are often misdiagnosed. The radiological changes are not specific. The ideal treatment comprises complete excision with proper internal fixation, which can significantly reduce postoperative recurrence.

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“…The cervical spine was the most common site, followed by the lumbar and thoracic spines [3]. TSGCT of the cervical spine usually occurs in the lower cervical vertebrae, and to the best of our knowledge, there have been only 10 cases of this tumor occurring at C1-C2 (Table 1) [3][4][5][6][7][8][9][10]. TSGCT of the spine is considered to arise from the facet joint synovium [11], and often grows extra-articularly and invades the posterior elements of the vertebra [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…In many of the reported cases occurring in C1-C2, bone erosion was seen in the facet between C1 and C2 or atlantoaxial joint, suggesting that the tumors originated from these sites. However, it has also been reported that there were no obvious bony lesions [7,8,10], the origins of the tumors were speculated to be the bursa [7] or vertebra membrane [10] in such cases. In our case, CT showed no bony lesion in the facet or atlantoaxial joint, suggesting that the tumor may have originated from the bursa or vertebra membrane, as in the previously reported cases [7,10], or from the tendon sheath of the paravertebral muscles.…”

Section: Discussionmentioning

confidence: 99%

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Tenosynovial giant cell tumor of the cervical spine: a case report

Furuhata

Iwanami

Tsuji

et al. 2019

Spinal Cord Ser Cases

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Introduction Tenosynovial giant cell tumors (TSGCTs) generally occur in the limb joints, and only rarely in the spine. This case report describes a patient with TSGCT of the spine at C1-C2, which was treated surgically and diagnosed as TSGCT. Case presentation A 32-year-old woman with a 4-month history of neck pain and numbness in both upper extremities was referred to our department. Magnetic resonance imaging (MRI) revealed a neoplastic lesion extending from the left epidural space to the erector spinae muscles at the C1-C2 vertebral level, which was isointense on T1-weighted images, heterogeneously hypointense on T2-weighted images, and showed heterogeneous enhancement on gadopentetate dimeglumine (Gd-DTPA)-enhanced T1-weighted images. Computed tomography showed no findings suggestive of bone destruction of the vertebral body. Because the neurological symptoms were progressive, total macroscopic resection of the tumor was performed via a posterior approach. Histopathological examination of the resected specimen revealed the diagnosis of TSGCT. Improvement of the both the neck pain and upper-extremity numbness was noted postoperatively. An MRI obtained 6 months after the surgery revealed no evidence of tumor recurrence and the postoperative course was uneventful. Discussion TSGCT of the upper cervical spine (C1-C2) is rare, and this is the tenth reported case. If a tumor is heterogeneously hypointense on T2-weighted MRI, which reflects hemosiderosis, the possibility of this tumor should be considered in the differential diagnosis.

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Giant cell tumor of the tendon sheath arising from a membrane surrounding the posterior arch of C1: a case report

Cited by 15 publications

References 20 publications

Tenosynovial Giant Cell Tumor of the Cervical Spine: Case Report and Review of the Literature

Tenosynovial Giant Cell Tumor of the Cervical Spine: Case Report and Review of the Literature

Tenosynovial giant cell tumor involving the cervical spine: A case report

Tenosynovial giant cell tumor of the cervical spine: a case report

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