Giant cell tumor of the distal common bile duct: report of a rare, benign entity that may mimic malignant biliary obstruction

Kolokotronis, Theodoros; Glanemann, Matthias; Wagner, Mathias; Bohle, Rainer M.; Grünhage, F

doi:10.1007/s00384-013-1798-2

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…Although we believe this is the first case report of UC-OGC in extrahepatic bile duct, a few similar entities in the literature were reported and deserve review. Giant cell tumor (GCT) of the extrahepatic biliary tree, which bears its name and histology analogy to the bone counterpart (16)(17)(18), is considered benign, although it is also composed of a mixture of mononuclear and multinucleated osteoclast-like giant cells. However, different than UC-OGC, the mononuclear cells in GCT do not express any cytokeratin, indicating mesenchymal rather than epithelial origin, as seen in our case.…”

Section: Discussionmentioning

confidence: 99%

Polypoid Undifferentiated Carcinoma With Osteoclast-like Giant Cells Arising in the Distal Common Bile Duct: A Rare Case Report

et al. 2018

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Background: Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) in distal common bile duct (CBD) is a rare entity. Case report: This case report describes a 45-year-old male with a history of a choledochal cyst status post partial excision and cholecystectomy who presented with a mass in the remaining distal/intrapancreatic common bile duct. It was initially mistaken for post-surgery hematoma; however, the rapid growth raised concern for malignancy, and prompted a pancreaticoduodenectomy (Whipple) procedure. Macroscopic examination revealed a 5.5 cm polypoid mass grossly confined in the lumen of the distal CBD. Histology was consistent with UC-OGC, with minimal invasion into the polyp stalk and adjacent CBD wall. Immunohistochemistry demonstrated co-expression of CK7 and p40, normal/wild-type p53, and retained SMAD4 expression in tumor cells. Next-generation sequencing detected mutations at p.Q61H (c.183A>C) of KRAS and p.E545K (c.1633G>A) of PIK3CA, keeping in line with similarity to conventional cholangiocarcinoma. The patient remained disease-free after two years of follow-up without chemotherapy. Conclusion: To our knowledge, this is the first case report of UC-OGC presented as a polypoid mass in the distal CBD. It highlights the complex dynamism and controversial pathogenesis of this unique entity, which should be made aware to avoid diagnostic pitfalls.

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Section: Discussionmentioning

confidence: 99%

Polypoid Undifferentiated Carcinoma With Osteoclast-like Giant Cells Arising in the Distal Common Bile Duct: A Rare Case Report

et al. 2018

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“…4 Another few similar cases have been reported in the region although there are skeptical comments against benign GCT of the EHBD. [5][6][7] The distinction between biliary adenocarcinoma with GCTlike component and benign GCT of the EHBD is crucial because the former is believed to behave in an aggressive fashion. Herein we present a case of EHBD adenocarcinoma morphologically indistinguishable from benign GCT of the EHBD, and would like to emphasize that it could be quite difficult or might be impossible to differentiate between undifferentiated adenocarcinoma with GCT-like component and benign GCT of the EHBD.…”

Section: Polypoid Extrahepatic Bile Duct Carcinoma Morphologically Inmentioning

confidence: 99%

Polypoid extrahepatic bile duct carcinoma morphologically indistinguishable from benign giant cell tumor

Tamura

Doi

Adachi

2015

Pathology International

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Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Common Bile Duct: A Case Report of a Rare Entity at an Unusual Location

Chen

2022

Diagnostics

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Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) is a rare variant of carcinoma with unique radiological and pathological features. This unusual carcinoma has been reported in a variety of organs and pancreas is the most frequently involved anatomical site. UCOGC of pancreas attains a relatively indolent clinical behavior and should be distinguished from ordinary pancreatobiliary adenocarcinoma. This paper presents the first case of UCOGC involving the entire segment of common bile duct (CBD) and common hepatic duct (CHD) without extending to the pancreatic tissue. Getting familiar with its clinical, radiological and pathological characters can help establish accurate diagnosis despite the occurrence of an unusual location.

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Giant cell tumor of the distal common bile duct: report of a rare, benign entity that may mimic malignant biliary obstruction

Cited by 4 publications

References 4 publications

Polypoid Undifferentiated Carcinoma With Osteoclast-like Giant Cells Arising in the Distal Common Bile Duct: A Rare Case Report

Polypoid Undifferentiated Carcinoma With Osteoclast-like Giant Cells Arising in the Distal Common Bile Duct: A Rare Case Report

Polypoid extrahepatic bile duct carcinoma morphologically indistinguishable from benign giant cell tumor

Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Common Bile Duct: A Case Report of a Rare Entity at an Unusual Location

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