Giant Cell Tumor of Major Salivary Glands: Report of Three Cases, One Occurring in Association with a Malignant Mixed Tumor

Eusebi, Vincenzo; Martin, Scott A.; Govoni, E; Rosaí, Juan

doi:10.1093/ajcp/81.5.666

Cited by 63 publications

(48 citation statements)

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“…In most instances, the giant cell component has an osteoclast-like appearance and is related to stromal hemorrhage. This situation has been reported in thyroid gland [6], pancreas [7], liver [12], gall bladder [8], salivary glands [5], colon [4], ovary [17], kidney [3], renal pelvis [11], urinary bladder [10], breast [19], and larynx [16]. In other cases, often from lung origin [1,2,9,15] but also occurring in pancreas [13], urinary bladder [10], and other sites, the giant cells are neoplastic and are associated with poor differentiation and dismal prognosis.…”

Section: Introductionsupporting

confidence: 53%

Renal cell carcinoma with syncytial giant cell component

et al. 2001

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We report a case of clear cell renal cell carcinoma in which a prominent multinucleated giant cell component was intermingled with clear, granular, and spindle cells. Histological, ultrastructural, cytometric, and cytogenetic features of giant cells were similar to those of mononucleated cells in the tumor, and therefore they were not from stromal or osteoclast derivation. These giant cells had homogeneous, finely granular, abundant cytoplasm, often with scalloped cell borders, and contained from 5 to more than 50 nuclei, all of them very similar in size and shape, with prominent central nucleoli. Occasionally, surrounding inflammatory cells were also engulfed in the cytoplasm. This syncytial appearance was more similar to that of some giant cell carcinomas from the lung than to the pleomorphic giant cells often encountered in high grade renal cell tumors. Although the patient is alive and free of disease 6 years after diagnosis, a longer follow-up will be required to assess the potential prognostic influence of this peculiar histological appearance.

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Section: Introductionsupporting

confidence: 53%

Renal cell carcinoma with syncytial giant cell component

et al. 2001

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“…Occurrence of the tumors with the same histology is also known in visceral organs, such as the liver, gall bladder, pancreas, salivary gland, thyroid, skin, heart, lung, breast, intestine, larynx, and female genital tract, where they have been termed 'osteoclastoma-like giant-cell tumor' or 'giant-cell tumor.' [1][2][3][4][5][6][7][8][9] To the best of our knowledge, less than 20 case reports (maximum two cases per report) of osteoclast-like giant-cell tumor of the urothelial tract have been published in the English literature. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Our study is the largest series in the literature of osteoclast-like giant-cell tumors arising in the urinary tract, and includes six patients.…”

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confidence: 99%

Osteoclast-rich undifferentiated carcinomas of the urinary tract

2006

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Osteoclast-like giant-cell neoplasms of the urinary tract are rare. They are composed of ovoid or spindle-shaped mononuclear cells with evenly spaced osteoclast-like giant cells. Terminology, histogenesis, and biologic behavior of these tumors remain controversial. Six cases of osteoclast-like giant-cell neoplasms of the urinary tract were identified from the consultation files of two of the authors. Patients were all male and elderly (range 65-82), with the exception of one 39-year-old male. In all, 3/6 tumors developed in the bladder and 3/6 in the renal pelvis. Size ranged from 5 to 11 cm. One bladder and three renal pelvis tumors were high stage (pT3) at time of presentation. Adjacent to the osteoclast-like giant-cell neoplasm in the same specimen, all patients had urothelial carcinoma in situ and/or high-grade papillary urothelial carcinoma. Multinucleated cells had identical morphological and immunohistochemical properties of osteoclasts; positive for CD-68, LCA, CD51 and CD54, and negative for cytokeratins and EMA. Varying percentages of mononuclear cells expressed a-smooth muscle actin (4/6), desmin (1/6), S-100 (4/6), LCA (2/6) and CD68 (6/6). However, mononuclear cells were also positive for epithelial markers in 4/6 tumors (cytokeratins AE-1/AE-3, Cam 5.2, CK7 and/or EMA). p53 stained mononuclear tumor cells in three cases, paralleling the staining on the accompanying urothelial carcinoma. Ki-67 stained mononuclear tumor cells, but not osteoclast-like giant cells. Follow-up data were available in five cases. One patient developed recurrence of noninvasive urothelial carcinoma and is still alive. Four patients were dead due to disease within 15 months, three with distant metastases. The intimate association of these tumors with urothelial carcinoma along with their immunohistochemical profile supports an epithelial origin for the mononuclear cells and non-neoplastic reactive histiocytic lineage for the osteoclast-like giant cells.

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“…As reported in the recent review [28][29][30] , most cases of the GCT-ST are arose from extremities involving either superficial or deep soft tissue. From our review of all the English-language literature, seventeen cases, including our case, were identified as GCT-ST arose in the oral and maxillofacial region [13][14][15][16][17][18][19][20][21][22][23][24][25] . About 82 % (14/ 17) have occurred in the parotid gland, most of which were associated with a carcinomatous component.…”

Section: Discussionmentioning

confidence: 99%

“…Primary GCT of soft tissue (GCT-ST) was originally demonstrated by Salm and Sissons in 1972 9) , followed shortly by Guccion and Enzinger 10) . In the oral and maxillofacial region, not frequent site for GCT, most cases affect the mandible and maxilla 2,11,12) and some cases located in the salivary gland [13][14][15][16][17][18][19][20][21][22][23][24] or nasal cavity 25) have been reported as primary soft tissue analogue in this region. Despite the majority of GCT in the oral and maxillofacial region are histologically comprised of an abundance of multinucleate giant cells and homogeneous population of round to polygonal mononuclear cells in the background 11) with poor cellular atypia and mitotic figures, some of them have revealed a carcinomatous component [13][14][15][17][18][19][20][22][23][24] , local recurrence 2,3) or malignant transformation like those in the extremities.…”

Section: Introductionmentioning

confidence: 99%

Primary Giant Cell Tumor of Soft Tissue in the Mental Region

Tanaka

Shen

Hasegawa

et al. 2012

J. Hard Tissue Biology.

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Giant cell tumors of soft tissue (GCT-ST) are considered to be the soft tissue analogue of giant cell tumors of bone. Although the majority of GCT-ST cases manifest histologically benign features, special consideration is required because GCT-ST can occasionally demonstrate extensive local invasion or distant metastases. Here, we present an extremely rare case of GCT-ST arising from subcutaneous mental soft tissue, rapidly growing over the mandibular gingiva and bone, and lacking overtly malignant features in clinical, radiological and cytological findings.

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Giant Cell Tumor of Major Salivary Glands: Report of Three Cases, One Occurring in Association with a Malignant Mixed Tumor

Cited by 63 publications

References 0 publications

Renal cell carcinoma with syncytial giant cell component

Renal cell carcinoma with syncytial giant cell component

Osteoclast-rich undifferentiated carcinomas of the urinary tract

Primary Giant Cell Tumor of Soft Tissue in the Mental Region

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