Giant Cell Temporal Arteritis Associated with Overlying Basal Cell Carcinoma: Co-Incidence or Connection?

Mahé, Etienne; Demellawy, Dina El; Bane, Anita; Alowami, Salem

doi:10.4081/rt.2012.e46

Cited by 2 publications

(1 citation statement)

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“…[60][61][62][63] However, some cases of concomitant nonmelanoma skin cancer and GCA have been reported. 64,65 Mahe et al 65 reported a patient referred to the dermatology clinic due to a left temporal ulcerating skin lesion. Excision of the cutaneous lesion revealed an ulcerating basal cell carcinoma.…”

Section: Cutaneous Diseases Associated With Giant Cell Arteritis Genementioning

confidence: 99%

A Review of the Dermatological Complications of Giant Cell Arteritis

Prieto-Peña¹,

Castañeda²,

Atienza‐Mateo³

et al. 2021

CCID

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Giant cell arteritis (GCA) is characterized by granulomatous inflammation of large and medium-sized vessels. It is the most common vasculitis among elderly people in Europe and North America. GCA usually presents with ischemic cranial manifestations such as headache, scalp tenderness, visual manifestations, and claudication of the tongue and jaw. Thickness and tenderness of temporal arteries are the most recognizable signs of GCA on physical examination. Laboratory tests usually show raised acute phase reactants. Skin manifestations are uncommon in GCA and are rarely found as a presenting symptom of GCA. Necrosis of the scalp and tongue is the most common ischemic cutaneous manifestation of GCA. Although infrequent, when present it reflects severe affection and poor prognosis of GCA. Panniculitis-like lesions have been reported in the setting of GCA, with nodules being the most common finding. Other entities, such as generalized granuloma annulare or basal cell carcinoma have been occasionally described in GCA patients. Prompt recognition and initiation of therapy are crucial to prevent serious complications of GCA. When high suspicion of GCA exists, immediate administration of glucocorticoids is recommended. It is advisable to refer the patient to a specialist GCA team for further multidisciplinary assessment.

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