Giant cell lichenoid dermatitis

González, Juan Guillermo; Marcus, Morris D.; Cruz, Daniel J. Santa

doi:10.1016/s0190-9622(86)70148-5

Cited by 31 publications

(28 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar lichenoid and granulomatous histopathologic features, 18 as observed in our case, have been designated as giant cell lichenoid dermatitis 19 and were associated with sarcoidosis 20 or herpes zoster scars. 21 Recognition of novel drug reaction patterns is important for dermatopathologists.…”

Section: Discussionsupporting

confidence: 80%

Erythroderma with lichenoid granulomatous features induced by erythropoietin

et al. 2005

View full text Add to dashboard Cite

The increasing use of new drugs in cancer therapy, especially growth factors, hormones, and chemotherapies resulted in several reports of unusual skin eruptions. We studied a patient with erythroderma who had received erythropoietin because of myeloma with tumor anemia. The histological features were characterized by a lichenoid, focally granulomatous infiltrate with predominance of histiocytes. It is important for dermatopathologists to recognize this interesting pattern induced by erythropoietin.

show abstract

Section: Discussionsupporting

confidence: 80%

Erythroderma with lichenoid granulomatous features induced by erythropoietin

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Clinically it is characterized by itchy erythematous and violaceous macules, papules, plaques or nodules with or without scaling, usually distributed on the trunk and extremities, although face, scalp, palms and mucosa may also be involved. 1,2 The exact pathogenesis of this entity is unknown. It was first reported as a lichenoid drug reaction presenting as generalized pruritic papulosquamous eruption secondary to methyldopa and chlorothiazide in a patient with systemic lupus erythematosus.…”

mentioning

confidence: 99%

“…It was first reported as a lichenoid drug reaction presenting as generalized pruritic papulosquamous eruption secondary to methyldopa and chlorothiazide in a patient with systemic lupus erythematosus. 1 Goldberg et al 2 reported 3 cases of GCLD, all of whom had drugs as the inciting factor. GCLD has also been reported in a patient with baboon syndrome 3 days after administering amoxicillin-clavulanic acid.…”

mentioning

confidence: 99%

An unusual case of idiopathic localized giant cell lichenoid dermatitis

Khullar

Saikia

et al. 2017

J Cutan Pathol

View full text Add to dashboard Cite

“…The etiology of the giant cells can either be epithelial or histiocytic. Histiocytic epidermal multinucleated giant cells have been noted in giant cell lichenoid dermatitis [7,8] and lichen nitidus of the palms [9,10]. …”

Section: Discussionmentioning

confidence: 99%

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a

Cohen

Paravar

Lee

2014

Dermatol Pract Concept

View full text Add to dashboard Cite

Background:Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections.Purpose:To review the histologic differential diagnosis of conditions with epithelial and histiocytic multinucleated giant cells—since multinucleated giant cells in the epidermis are not always pathognomonic of a cutaneous herpes virus infection—and to summarize dermatoses in which herpes virus infection has been observed to coexist.Methods:Two individuals with acantholytic dermatoses whose initial lesional skin biopsies showed multinucleated epithelial giant cells suggestive of a herpes virus infection are reported. Using the PubMed database, an extensive literature search was performed on multinucleated giant cell (and epidermis, epithelial, and histiocytic) and herpes virus infection. Relevant papers were reviewed to discover the skin conditions with either multinucleated giant cells in the epidermis or coincident cutaneous herpes virus infection.Results:Initial skin biopsies from patients with either pemphigus vulgaris or transient acantholytic dermatosis mimicked herpes virus infection; however, laboratory studies and repeat biopsies established the correct diagnosis of their acantholytic dermatosis. Hence, epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection. Indeed, epithelial multinucleated giant cells in the epidermis can be observed not only in the presence of infection (herpes virus), but also acantholytic dermatoses and tumors (trichoepithelioma and pleomorphic basal cell carcinoma). Histiocytic multinucleated giant cells in the epidermis can be observed in patients with either giant cell lichenoid dermatitis or lichen nitidus of the palms.Conclusions:Epithelial and histiocytic multinucleated giant cell can occur in the epidermis. Keratinocyte-derived multinucleated giant cells are most commonly associated with herpes virus infection; yet, they can also be observed in patients with skin tumors or acantholytic dermatoses. Cutaneous herpes simplex virus infection can coexist in association with other conditions such as acantholytic dermatoses, benign skin tumors, bullous disorders, hematologic malignancies, inflammatory dermatoses, and physical therapies. However, when a herpes virus infection is suspected based upon the discovery of epithelial multinucleated giant cells in the epidermis, but either the clinic presentation or lack of response to viral therapy or absence of confirmatory laboratory studies does not support the diagnosis of a viral infection, the possibility of a primary acantholytic dermatosis should be considered and additional lesional skin biopsies performed. Also, because hematoxylin and eosin staining is not the golden standard for confirmation of autoimmune bullous dermatoses, skin biopsies for direct immunofluorescence should be performed when a primary bullous dermatosis is suspected since the histopathology observed on hematoxylin and eosin stai...

show abstract

Giant cell lichenoid dermatitis

Cited by 31 publications

References 1 publication

Erythroderma with lichenoid granulomatous features induced by erythropoietin

Erythroderma with lichenoid granulomatous features induced by erythropoietin

An unusual case of idiopathic localized giant cell lichenoid dermatitis

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a

Contact Info

Product

Resources

About