Giant-Cell Carcinoma of the Lungs. An Analysis of 12 Cases

Guillan, Ramon A.; Zelman, Samuel

doi:10.1093/ajcp/46.4.427

Cited by 20 publications

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“…Fishback et al reported that the single large pleomorphic nucleus of GC measured greater than the diameter of four small resting lymphocytes [14]. Guillan and Zelman reported that the giant cells varied in size from 50 to 120 µm in diameter [15], and Hellstrom and Fisher reported that the giant cells measured from 80 to 100 µm [16]. This vague definition of giant cells causes confusion among pathologists.…”

Section: Discussionmentioning

confidence: 99%

Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas

Hiroshima

Dosaka‐Akita²,

Usuda³

et al. 2011

Acta Cytologica

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Objective: To establish cytological features of pulmonary pleomorphic carcinoma (PC) or giant cell carcinoma (GC), we evaluated the cytological characteristics of these tumors using a multidisciplinary approach. Study Design: Samples from 13 surgically resected and histologically confirmed PC or GC patients were collected from our institutes. Eight cases without prior chemotherapy before surgery were selected, and cytological features were analyzed. Results: The background contained numerous lymphocytes and neutrophils. The tumor cells were arranged in flat loose clusters, but some were in fascicles. The shape of the tumor cell was spindle or pleomorphic, and the sizes of the tumor cells varied by more than 5-fold. The tumor cells had an abundant, thick and well-demarcated cytoplasm. The location of the nucleus was centrifugal, and the nucleus was oval or irregularly shaped. Multinucleated giant cells were frequently observed. The size of the nucleus was more than 5 times that of normal lymphocytes, and its size also varied by more than 5-fold. The nuclear membrane was thin, and nuclear chromatin was coarsely granular, while the nucleolus was single and round. Conclusion: PC or GC has characteristic cytological features, however, spindle cells tended to be hardly observed in cytological specimens in some cases.

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Section: Discussionmentioning

confidence: 99%

Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas

Hiroshima

Dosaka‐Akita²,

Usuda³

et al. 2011

Acta Cytologica

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“…Therefore, we confined our analysis to males. The 111 male cases with smoking data were found in 23 independent studies (Bendel & Ishak, 1961;Broderick et al, 1975;Dailey & Marcuse, 1969;DeAngelis et al, 1961;Flanagan & Roeckel, 1964;Friedberg, 1965;Gajaraj et al, 1971;Guillan & Zelman, 1966;Hathaway et al, 1969;Hellstrom & Fisher, 1963;Horie & Ohta, 1981;Kallenberg & Jaque, 1979;Kennedy, 1969;Lerner, 1967;Naib, 1961;Matsuo et al, 1986;Nash & Stout, 1958;Pfeffer & Stoven, 1978;Pfitzer & Knoblich, 1975;Shin et al, 1986;Thomas, 1962;Wang et al, 1976). (Although not reported as such in the publication, one woman in the study of Shin et al (1986) was a smoker, as were 8 of the 13 men; Shin, personal communication.…”

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confidence: 95%

Pulmonary giant cell carcinoma: the relation to smoking

Depue

Ballard²

1989

Br J Cancer

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“…Fishback et al2 reported that the single large pleomorphic nucleus of a GC was 4 times larger than that of small resting lymphocytes. Guillan and Zelman17 reported that the GCs varied in diameter from 50 µm to 120 µm, and Hellstrom and Fisher18 reported that the GCs measured from 80 µm to 100 µm. This vague definition of GCs has caused confusion among pathologists.…”

Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung

et al. 2012

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BackgroundPleomorphic carcinoma (PC) is a rare pulmonary malignancy. Because of its rarity and histological heterogeneity, cytopathologists might suspect PC only rarely on the basis of its cytological specimen. In addition, cytological findings from fine needle aspiration (FNA) specimens have rarely been described. Hence, we investigated the cytological features of FNA in the cases of PC.MethodsWe reviewed 7 FNA specimens of PC. The patients had undergone surgical resection at the Korea Cancer Center Hospital between 2007 and 2011. The cytological features of PC were assessed and compared with the histopathological features of the corresponding surgical specimen. Immunocytochemical analysis with cytokeratin and vimentin was performed on the cell blocks.ResultsThe tumor cells were either dispersed or arranged in loose aggregates, and generally lacked any glandular or squamous differentiation. Pleomorphic or spindle shape tumor cells were observed, and mono-, bi-, or multi-nucleated giant cells were frequently observed. The background showed necrosis and contained numerous lymphocytes and neutrophils. Immunocytochemically, the tumor cells were positive for cytokeratin and vimentin.ConclusionsPC displays characteristic cytological features. It might therefore be possible to make an accurate diagnosis of PC by assessing the degree of nuclear atypia.

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Giant-Cell Carcinoma of the Lungs. An Analysis of 12 Cases

Cited by 20 publications

References 0 publications

Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas

Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas

Pulmonary giant cell carcinoma: the relation to smoking

Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung

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