Giant cell arteritis presenting with chronic cough and headache after BNT162b2 mRNA COVID-19 vaccination

Ishizuka, Kosuke; Katayama, Kohta; Ohira, Yoshiyuki

doi:10.1093/qjmed/hcac171

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…In early 2022, several case reports of large vessel and GCA developing after mRNA COVID-19 vaccination were published with multiple authors demonstrating the utility of fluorodeoxyglucose-positron emission tomography in conjunction with computed tomography imaging for diagnosis [16][17][18][19][20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Axillo-Brachial Artery Stenosis Following Messenger Ribonucleic Acid (mRNA) Vaccination Against Severe Acute Respiratory Coronavirus 2 (COVID-19)

Güven¹

2023

Cureus

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The following case report is an overview of an unusual presentation of bilateral axillo-brachial artery occlusion following messenger ribonucleic acid (mRNA) vaccination against severe acute respiratory coronavirus 2 (COVID-19). A 64-year-old female presented with symptoms initially consistent with polymyalgia rheumatica five weeks following the first booster of the Pfizer-BioNTech COVID-19 vaccine. She was successfully treated with prednisone therapy; however, despite the normalization of inflammatory markers, she later presented with bilaterally occluded axillo-brachial arteries. She successfully underwent endovascular management for the treatment of her symptoms. To our knowledge, this is the first case report of chronically occluded bilateral axillo-brachial artery disease following mRNA vaccination for COVID-19 successfully treated with endovascular therapy. The unusual pathogenesis of upper extremity arterial disease is reviewed and a review of endovascular treatment options is presented. A literature review of the types of vasculitis seen following mRNA COVID-19 vaccination is also presented.

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Section: Discussionmentioning

confidence: 99%

Bilateral Axillo-Brachial Artery Stenosis Following Messenger Ribonucleic Acid (mRNA) Vaccination Against Severe Acute Respiratory Coronavirus 2 (COVID-19)

Güven¹

2023

Cureus

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“…Several reports have proposed a link between vaccination against SARS-CoV2 with an mRNA vaccine and the development of GCA (Table 1). [4][5][6][7][8] Six patients developed GCA after vaccination against SARS-CoV2; of those, 2 and 4 patients had received the viral vector vaccine and the mRNA vaccine, respectively. The onset time did not depend on the number of vaccinations, and all cases of GCA developed within 10 days after vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…Cadiou et al [6] Cadiou et al [6] Anzola et al [5] Greb et al [4] Xia et al [8] Ishizuka et al [7] Present case vaccination against SARS-CoV2 is lower than that noted for conventional GCA (the sensitivity of temporal artery biopsy in conventional GCA is 92.9%). [1] The function of mRNA vaccines is based on the following steps: translation of mRNA encoding the viral antigen by intracellular ribosomes; production of the spike protein; presentation of the spike as antigen the cell surface by the major histocompatibility complex; and production of antibodies against the target virus.…”

Section: Tablementioning

confidence: 90%

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Development of giant cell arteritis after vaccination against SARS-CoV2: A case report and literature review

Wakabayashi,

Iwayanagi,

Sakai

et al. 2023

Medicine

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Rationale: Giant cell arteritis (GCA) is an autoimmune vasculitis that affects large and medium-sized blood vessels. The mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has been associated with the development of immune-mediated diseases. In this article, we present a case of GCA that developed after vaccination against SARS-CoV2. Patient concerns: A 77-year-old man developed fever, general fatigue, and headache 1 day after the third dose of vaccination against SARS-CoV2. Nodular swelling and tenderness of the bilateral temporal arteries were observed. Diagnoses: Although right temporal artery biopsies were negative, the patient was diagnosed with GCA based on criteria established by the American College of Rheumatology for the classification of GCA. Interventions: The patient received methylprednisolone 1000 mg for 3 days. This was followed by prednisolone 1 mg/kg/d, which was decreased by 10 mg every week to 30 mg. From day 16 of hospitalization, the patient received tocilizumab 162 mg/wk every other week. Outcomes: There was no occurrence of acute side effects. After 38 days of treatment, the condition improved and the patient was discharged from the hospital; as stated above, the dose of prednisolone was tapered to 30 mg/d. Lessons: We experienced a case of GCA that occurred immediately after vaccination against SARS-CoV2 with an mRNA vaccine. Early signs of GCA include fever, fatigue, and headache, and often resemble those noted after vaccination against SARS-CoV2. The potential presence of GCA should be determined in individuals with persistent fever and headache after vaccination against SARS-CoV2.

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“…Interessanterweise wurde das Auftreten einer Vaskulitis auch nach Impfung gegen SARS-CoV-2 beschrieben [43,44,45,46]…”

Section: Covid-19 Als Trigger Für Vaskulitis Und Aortitisunclassified

Takayasu – Arteriitis nach COVID-19-Infektion bei einer 26 Jahre alten Patientin mit Morbus Crohn

Kollecker,

Nistal,

Waltz

et al. 2024

Z Gastroenterol

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ZusammenfassungExtraintestinale Manifestationen z.B. an Haut, Gelenken oder Leber finden sich bei Morbus Crohn häufig. Wir berichten über eine 26 Jahre alte Patientin mit langjährig bekanntem Morbus Crohn, die bei V.a. erneuten akuten Schub bei suggestiver Klinik und laborchemisch deutlich erhöhten Entzündungswerten stationär aufgenommen wurde. Kurze Zeit vorher war die Diagnose einer symptomatischen COVID-19-Erkrankung (SARS-CoV-2-Variante Omikron) gestellt worden. Mittels umfassender endoskopischer und bildgebender Diagnostik konnte eine aktive Crohn-Erkrankung ausgeschlossen werden. Es zeigte sich jedoch eine langstreckige entzündliche Verdickung des Aortenbogens, sodass die Diagnose einer Takayasu-Arteriitis (Typ II b) gestellt werden konnte. Unter Steroidtherapie kam es zu einer raschen und anhaltenden Besserung der klinischen Symptomatik. Das Auftreten einer Takayasu-Arteriitis ist außerhalb von Japan ausgesprochen selten. Eine Koinzidenz mit chronisch entzündlichen Darmerkrankungen ist beschrieben und wird als mögliche extraintestinale Manifestation diskutiert. Das Auftreten immunvermittelter Erkrankungen nach COVID-19-Erkrankungen ist beschrieben und wird möglicherweise durch die Infektion getriggert. Patienten mit chronisch entzündlichen Darmerkrankungen könnten möglicherweise eine besondere Risikopopulation darstellen.

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Giant cell arteritis presenting with chronic cough and headache after BNT162b2 mRNA COVID-19 vaccination

Cited by 9 publications

References 6 publications

Bilateral Axillo-Brachial Artery Stenosis Following Messenger Ribonucleic Acid (mRNA) Vaccination Against Severe Acute Respiratory Coronavirus 2 (COVID-19)

Bilateral Axillo-Brachial Artery Stenosis Following Messenger Ribonucleic Acid (mRNA) Vaccination Against Severe Acute Respiratory Coronavirus 2 (COVID-19)

Development of giant cell arteritis after vaccination against SARS-CoV2: A case report and literature review

Takayasu – Arteriitis nach COVID-19-Infektion bei einer 26 Jahre alten Patientin mit Morbus Crohn

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