Giant cell arteritis and inflammatory bowel disease – Is there a connection? Results from a population-based study

Yavne, Yarden; Tiosano, Shmuel; Ben-Ami, Dana; Watad, Abdulla; Guy, Adi; Comaneshter, Doron; Cohen, Arnon D; Amital, Howard

doi:10.1016/j.autrev.2018.06.003

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…The data undergo an extensive series of cross-check and quality verification by comparing diagnoses from various sources. The validity of the data was verified to be high, as shown in previously published studies (11–14). Wide-scale epidemiological studies can be conducted in real time on heterogeneous groups using advanced, massive data-mining techniques from the database.…”

Section: Methodssupporting

confidence: 78%

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study

et al. 2019

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Objectives: To test the hypothesis that familial Mediterranean fever (FMF)-associated autoinflammation may exaggerate the tendency toward adaptive immunopathology or spondyloarthritis (SpA)-associated disorders including major histocompatibility complex (MHC) class I associated disorders but not classical MHC class II-associated disorders that exhibit transplacental autoimmunity including myasthenia gravis and pemphigus.Methods: Seven thousand seven hundred forty-seven FMF patients and 10,080 age- and sex-matched controls in the Clalit Health Services medical database were identified and compared in terms of prevalence of SpA-associated disorders. We also evaluated four classical and strong MHC class II-associated disorders, namely, pemphigus vulgaris, myasthenia gravis, sarcoidosis, and pernicious anemia, to ascertain whether such associations with SpA-spectrum disease were specific or merely reflected the non-specific consequences of innate immune system activation on driving divergent types of immunity. The diagnosis of FMF was based on the medical records and not genetically proven.Results: FMF showed a strong association with MHC class I-related diseases: odds ratio (OR) of 28.58 [95% confidence interval (95% CI), 6.93–117.87; p < 0.0001] for Behçet's disease, OR of 10.33 (95% CI, 4.09–26.09; p < 0.0001) for ankylosing spondylitis, and OR of 1.67 (95% CI, 1.19–2.33; p = 0.0029) for psoriasis. For weakly MHC class I-linked diseases, an OR of 3.76 (95% CI, 2.48–5.69; p < 0.0001) for Crohn's disease and OR of 2.64 (95% CI, 1.52–4.56; p = 0.0005) for ulcerative colitis were found. No association was found between FMF and the four MHC class II-associated autoimmune disorders.Conclusion: FMF patients are associated with increased risk of SpA-related disease diagnosis including MHC-I-opathies but not MHC-II-associated autoimmune diseases, suggesting that tissue-specific dysregulation of innate immunity share between FMF and SpA spectrum disorders may drive adaptive immune MHC class I-associated conditions.

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Section: Methodssupporting

confidence: 78%

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study

et al. 2019

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Section: Discussionunclassified

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2020

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Pu bli ca ción tri mes tral. Re ser va dos to dos los de re chos. Nin gu na par te de es ta pu bli ca ción pue de ser re pro du ci da en for ma o me dio al gu no, elec tró ni co o me cá ni co, in clu yen do fo to co pias, gra ba cio nes y otros sis te mas de in for ma ción sin la au to ri za ción expresa por parte de los editores. La responsabilidad por los juicios, opiniones, pun tos de vista o traducciones expresados en los artículos publicados corresponde ex clusivamente a sus autores..

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“…En los pacientes con ACG, las masas solo se localizaron en mama u ovario 48 . Se han reportado asociaciones de ACG con tiroideopatía, con enfermedad coronaria (la cual es una de las causas de mortalidad en estos pacientes además de las infecciones), con enfermedad inflamatoria intestinal y con cáncer, entre otras [54][55][56][57][58][59][60] . Con respecto a las neoplasias, los nuevos trabajos no muestran mayor riesgo de malignidad en pacientes con ACG en relación a la población general, aunque algunos muestran sí mayor riesgo de leucemia [57][58][59] .…”

Section: Discussionunclassified

Arteritis de células gigantes: análisis de 15 casos

Young¹

2020

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Introducción. La arteritis de células gigantes es un trastorno inflamatorio cróni co caracterizado por el compromiso de vasos de mediano y gran calibre que afecta principalmente las ramas craneales que emergen del arco aórtico. Materiales y métodos. Se analizaron de manera retrospectiva pacientes con diagnóstico de arteritis de células gigantes diagnosticados entre 2000 y 2016. Resultados. Se incluyeron 15 pacientes, de los que 11 (73.33%) eran mujeres. La edad promedio al diagnóstico fue de 68.53±9.13 años (rango: 5381). El 46.67% asoció polimialgia reumática. Las características clínicas más frecuentes fueron cefalea, anormalidades en la arteria temporal y claudicación mandibu lar en un 66.67, 60 y 40%, respectivamente. Con respecto a los parámetros de laboratorio, el 80% presentó eritrosedimentación mayor a 50 mm/h y el 33% anemia. El 60% presentó biopsia confirmatoria. El 20% recibió pulsos endove nosos de metilprednisolona por déficit visual, el 13.33% requirió adición de me totrexato como ahorrador de corticoides. El 40% logró la remisión con des censo completo de corticoides en un promedio de 33 meses y el 33.33% ex perimentó recaídas. El déficit visual postratamiento fue del 20%. Conclusiones. El análisis de nuestros datos fue comparable con distintas series internacionales, y es la tercera serie local en importancia.

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Giant cell arteritis and inflammatory bowel disease – Is there a connection? Results from a population-based study

Cited by 12 publications

References 29 publications

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study

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Arteritis de células gigantes: análisis de 15 casos

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