Giant Cell Angiofibroma

Tos, Angelo Paolo Dei; Seregard, Stefan; Calonje, Eduardo; Chan, J. K. C.; Fletcher, C. D. M.

doi:10.1097/00000478-199511000-00009

Cited by 108 publications

(3 citation statements)

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“…Although it was firstly described as a distinct orbital neoplasm by Dei Tos [1], until now there are approximately 26 various extraorbital site cases reported in the literature [2-18] (Table 1). By taking into account the orbital GCA cases and extraorbital head and neck cases we could assume that GCA may have a predilection for the head and neck region.…”

Section: Discussionmentioning

confidence: 99%

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Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature

Zhang

Liu

et al. 2014

World J Surg Onc

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PurposeTo present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA).Case presentationIn this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformation for one year prior to surgical removal. We summarize the clinical manifestations, imaging, pathological and molecular features of this rare disease.After complete surgical removal of the tumor, immunohistochemical analysis revealed strong positivity for the mesenchymal markers vimentin, CD34, CD31 and CD99 in neoplastic cells. Tumor proliferation antigen marker Ki67 was partly positive (<5% of cells). Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8. The morphological and immunohistochemical profile was consistent with the diagnosis of GCA.ConclusionGCA is a rare soft tissue tumor that can easily be misdiagnosed in the clinical preoperative setting. In view of the clinical, pathological and molecular features of the tumor, complete surgical removal is the current optimal treatment option, providing accurate diagnosis and low to minimal recurrence rate.

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Section: Discussionmentioning

confidence: 99%

“…Giant cell angiofibroma (GCA) was first described by Dei Tos as a rare soft tissue tumor of the orbit [1]. Since the initial report of the disease in orbital tissue, GCA has been reported in a variety of other extraorbital sites [2-8].…”

Section: Introductionmentioning

confidence: 99%

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature

Zhang

Liu

et al. 2014

World J Surg Onc

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“…In 1995, Dei Tos et al [1]were the first to report giant cell angiofibroma (GCA) of the orbit in 7 cases. Since the original description, the tumour has been described at many extra-orbital locations.…”

Section: Introductionmentioning

confidence: 99%

Two Cases of STAT6-Positive, Primary Conjunctival Giant Cell-Rich Solitary Fibrous Tumour (Giant Cell Angiofibroma) with Some Unusual Histological Features

et al. 2020

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• Giant cell-rich solitary fibrous tumour (GCR-SFT) (giant cell angiofibroma) is a well-described soft tissue tumour that classically occurs in the orbit but very rarely presents in the conjunctiva. • GCR-SFT is positive immunohistochemically for STAT6, including the tumour giant cell nuclei. Novel Insights • We describe two cases of a unilateral inferior bulbar conjunctiva GCR-SFT with clear immunohistochemical demonstration of STAT6 positivity of the spindle, ovoid, and giant tumour cells at this location. • In one case, the giant cells resembled Touton giant cells with possible confusion with the histology of juvenile xanthogranuloma. • The same case showed a prominent stromal spindle melanocytic population, representing a likely collision with a subepithelial nevus.

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