Gianotti-Crosti syndrome: case report of a pruritic acral exanthema in a child

Abstract

Gianotti-Crosti syndrome (GCS) is a sporadic dermatosis affecting mainly children. It is characterized by multiple, confluent, monomorphic and pruritic pink to red-brown papules or papulovesicles, distributed symmetrically on the face, extensor surfaces of the extremities and buttocks, commonly sparing the trunk, palms and soles. This can be preceded by a viral infection, and may be accompanied by fever, hepatosplenomegaly, or lymphadenopathy. Personal and family history of atopy appears to be a risk factor in the subsequent development of GCS, thus frequently diagnosed as atopic dermatitis. We report a case of a 4-year-old boy from our institution with generalized, pruritic, papulovesicular rashes on the face and extremities for one month. He was diagnosed to have atopic dermatitis and treated as such, before presentation to our institution. As the signs and symptoms in GCS are similar to atopic dermatitis, we suggest that this diagnosis be considered when presented with a similar case.

Is Gianotti–Crosti Syndrome Associated with Atopy? A Case–Control Study and a Postulation on the Intrinsic Host Factors in Gianotti–Crosti Syndrome

“…The results of this study have some implications for clinicians who are managing children with GCS. Our results highlight the association between GCS and atopy, in line with the known difficulty in differentiating AD from AD with overlying GCS , although this knowledge linking GCS to atopy does not enable us to treat or prevent GCS. GCS is mostly a benign condition.…”

Atypical acral swelling and viral exanthem with parechovirus meningitis

“…Gianotti‐Crosti syndrome usually presents with small papulovesicular lesions over the extremities which are self‐resolving and heals with desquamation . This morphology of our patient's rash was different although the distribution was similar.…”

Pediatric idiopathic hypereosinophilic syndrome with Gianotti–Crosti syndrome: a novel presentation

“…), bacteria ( Bartonella henselae , Mycoplasma pneumoniae , etc. ), and recent immunizations . Atopy may also play a role in conditioning the onset of GCS .…”

“…), and recent immunizations . Atopy may also play a role in conditioning the onset of GCS . Allergic disease is characterized by eosinophilia and elevated serum IgE levels .…”