Gianotti‐crosti syndrome after COVID‐19 vaccination

Gianotti‐Crosti syndrome following COVID‐19 infection

“…For the best of our knowledge, only two cases of paediatric GCS were reported after COVID-19 infection (Table 1): Both developed rash after 3-4 weeks of COVID-19 symptoms and one of them had atopic disease like our patient, 2,4 two other cases of GCS was reported in adults, 5,6 and three cases after COVID-19 vaccination. 3,7 Physio-pathogeny remains unclear: Type IV hypersensitivity and IgE-mediated response was evoked: In fact, those patients presented elevated IgE for the most of them and like for our patient and had atopic diseases. Multisystemic inflammatory syndrome in children (MIS-C) is a post-infectious complication of COVID-19 infection: It includes fever, gastrointestinal distress and many unspecific dermatologic findings.…”

“…Between them we can cite: EBV, hepatitis B virus, hepatitis A virus, coxsackievirus, cytomegalovirus, enterovirus, ECHO viruses, respiratory syncytial virus and recently COVID-19 infection and vaccination. 3 Histological features of GCS are unspecific. The prognosis is excellent: The eruption may stay between 25 and 45 days, but it remains harmless and self-limited.…”