gHRV: Heart rate variability analysis made easy

“…This hardware dependency might be a disadvantage for some users. The most popular desktop applications for Heart Rate Variability analysis are: Kubios HRV software [30], CODESNA [31], SinusCor [32], gHRV [33], and others.…”

Section: Research Backgroundmentioning

confidence: 99%

Portable Sensor System for Registration, Processing and Mathematical Analysis of PPG Signals

et al. 2020

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This article introduces an integrated photoplethysmographic (PPG) based cardiovascular monitoring system that consists of an individually portable PPG device for recording photoplethysmographic signals and a software system with a serverless architecture for processing, storing, and analyzing the obtained signals. The portable device uses the optical plethysmography technique for measuring blood volume in blood vessels. The device was tested and validated by a comparative analysis of three photoplethysmographic signals and one Electrocardiographic signal registered simultaneously in the target subject. The comparative analysis of these signals shows insignificant deviations in the obtained results, with the mean squared error between the studied signals being less than 21 ms. This deviation cannot affect the results that were obtained from the analysis of the interval series tested. Based on this result, we assume that the detected signals with the proposed device are realistic. The designed software system processes the registered data, performs preprocessing, determines the pulse rate variability, and performs mathematical analysis of PP intervals. Two groups of subjects were studied: 42 patients with arrhythmia and 40 healthy controls. Mathematical methods for data analysis in time and frequency domain and nonlinear methods (Poincaré plots, Rescaled Range Plot, Detrended Fluctuation Analysis, and MultiFractal Detrended Fluctuation Analysis) are applied. The obtained results are presented in tabular form and some of them in graphical form. The parameters studied in the time and frequency domain, as well as with the nonlinear methods, have statistical significance (p < 0.05) and they can distinguish between the two studied groups. Visual analysis of PP intervals, based on Poincare’s nonlinear method, provides important information on the physiological status of patients, allowing for one to see at a glance the entire PP interval series and quickly detect cardiovascular disorders, if any. The photoplethysmographic data of healthy individuals and patients diagnosed with arrhythmia were recorded, processed, and examined through the system under the guidance of a cardiologist. The results were analyzed and it was concluded that this system could serve to monitor patients with cardiovascular diseases and, when the condition worsens, a signal could be generated and sent to the hospital for undertaking immediate measures to stabilize patient’s health.

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“…Free Serial Port Terminal 1.0.0.710 software. All data were analysed using gHRV 1.6 software (Rodriguez-Linares et al, 2014).…”

Section: Heart Rate Measurementsmentioning

confidence: 99%

Identification of a novel population of peripheral sensory neuron that regulates blood pressure

Morelli

Castaldi

Brown

et al. 2020

Preprint

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The vasculature is innervated by a network of peripheral afferents that sense and regulate blood flow. Here, we describe a system of non-peptidergic sensory neurons with cell bodies in the spinal ganglia that regulate vascular tone in the distal arteries. We identify a population of mechanosensitive neurons marked by TrkC and Tyrosine hydroxylase in the dorsal root ganglia that project to blood vessels. Local stimulation of these neurons decreases vessel diameter and blood flow, while systemic activation increases systolic blood pressure and heart rate variability via the sympathetic nervous system. Chemogenetic inactivation or ablation of the neurons provokes variability in local blood flow leading to a reduction in systolic blood pressure, increased heart rate variability and ultimately lethality within 48 hours. Thus, TrkC/Tyrosine hydroxylase positive sensory neurons form part of a sensory feedback mechanism that maintains cardiovascular homeostasis through the autonomic nervous system. Author contributionsCM, LC, SJB, LLS, AW, FJT, BC, AB, JS, TF, LS, BD and JS acquired data and performed analysis, KMB developed computational analysis methods for LSCI, RP, SGL, PAH gave feedback on experimental aspects, supervised experimental approaches, and implemented the data interpretation. LC prepared the figures. PAH designed the study with help from CM and LC and wrote the manuscript.

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gHRV: Heart rate variability analysis made easy

Cited by 41 publications

References 32 publications

Ectopic beats detection and correction methods: A review

Ectopic beats detection and correction methods: A review

Portable Sensor System for Registration, Processing and Mathematical Analysis of PPG Signals

Identification of a novel population of peripheral sensory neuron that regulates blood pressure

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