Ghrelins, obestatin, nesfatin-1 and leptin levels in pregnant women with and without hyperemesis gravidarum

Güngör, Sami; Gürateş, Bilgin; Aydın, Süleyman; Şahin, İ̇brahim; Kavak, Salih Burçin; Kumru, Selahattin; Çelik, Hüsnü; Aksoy, Aziz; Yılmaz, Musa; Çatak, Zekiye; Citil, Cihan; Baykuş, Yakup; Deniz, Rulin; Karakaya, Fethi; Özdemir, Nazan

doi:10.1016/j.clinbiochem.2013.01.015

Cited by 24 publications

(26 citation statements)

References 14 publications

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“…51 Lower levels of leptin were found in 1 study of 20 patients with HG compared with 20 controls as were higher levels of nesfatin-1, another hormone thought to regulate appetite and weight. 52 Of note, the leptin level results in this study differ from what has previously been reported in the literature 53 ; thus, further studies are needed to determine the role of hunger hormones in HG and whether they can serve as a marker for disease severity.…”

Section: Psychologic Factorscontrasting

confidence: 79%

Hyperemesis Gravidarum

2018

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Nausea and vomiting of pregnancy affect the majority of pregnancies, while the most severe version, hyperemesis gravidarum (HG), affects a much smaller subset of women. Despite the prevalence of nausea and vomiting of pregnancy and the severe consequences of HG, the pathophysiology of these conditions is not fully understood. Currently, it is thought that a combination of hormonal factors accounts for their development. Multiple treatments have been described for nausea and vomiting of pregnancy and HG with varying levels of success. In this paper we describe the epidemiology of nausea and vomiting of pregnancy and HG, the recommended workup, their proposed etiologic factors, treatments, and their potential impact on mother and baby.

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Section: Psychologic Factorscontrasting

confidence: 79%

Hyperemesis Gravidarum

2018

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“…Th e eff ect of Ramadan fasting on LH,FSH,oestrogen,progesterone and leptin in pregnant women 637 In pregnant women (who cannot eat regularly), the leptin concentration was signifi cantly lower in comparison to the control group (Gungor et al 2013).…”

Section: Discussionmentioning

confidence: 98%

The effect of Ramadan fasting on LH, FSH, oestrogen, progesterone and leptin in pregnant women

Khoshdel

Kheiri

Hashemi-Dehkordi

et al. 2014

Journal of Obstetrics and Gynaecology

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Many pregnant Muslim women fast during Ramadan. Leptin has an important role in the reproductive system and hormones. In this study, FSH, LH, oestrogen, progesterone and leptin were measured in the first, second and fourth week of Ramadan and the second week post-Ramadan, in 30 fasting pregnant women. Data were analysed using repeated measures ANOVA by SPSS. The weight and BMI did not change during the study. A significant change in FSH, oestrogen, progesterone and leptin was observed (p < 0.05). The lowest value of FSH was in the second week of Ramadan. Progesterone increased at the end of Ramadan and the second week after. Oestrogen increased significantly during Ramadan and decreased after Ramadan. A decreasing trend was seen in LH during the Ramadan and 2 weeks after (p < 0.1). Leptin decreased significantly 2 weeks after Ramadan. We found poor weight gain and hypoleptinaemia in pregnant fasted women during the study. Food restriction in pregnant fasted women during Ramadan may induce poor weight gain during pregnancy. These data confirm that Ramadan fasting by pregnant women may have potential risks during pregnancy. We recommend further study to evaluate long-term effects of Ramadan fasting during pregnancy in different countries with different food habits and traditions, to obtain reliable and documented data.

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“…Whether released nesfatin‐1 is implicated in DON‐induced vomiting remains an open question. The future studies should confirm it, because a pilot study has indicated that nesfatin‐1 might be involved in the hyperemesis gravidarum (Gungor et al , ).…”

Section: Identified and Potential Molecule Mechanisms Of Emesis Aftermentioning

confidence: 90%

Current and prospective sights in mechanism of deoxynivalenol‐induced emesis for future scientific study and clinical treatment

Chen

Zhao

Nüssler

et al. 2017

J of Applied Toxicology

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Deoxynivalenol (DON), one of trichothecene mycotoxins produced by the fungus Fusarium, is commonly detected in cereal foods and in secondary food production across the world. Lower concentrations of DON induce a dose-related feed refusal (anorexia), whereas it acts as a potent emetic agent at higher levels. DON-induced emesis in humans and livestock can be observed and recorded in both undeveloped and developed regions such as Lixian, Guide and Huangzhong in China and Illinois in the USA. Some studies with different animal models (pigs and minks) suggested that DON could change expressions of 5-hydroxytryptamine, peptide YY, neuropeptide Y2 receptor and nucleobindin-2/nesfatin-1 in plasma and different areas of the brain. Some selective antagonist of 5-hydroxytryptamine 3 receptors can inhibit DON-induced emetic response. Otherwise, the Ca homeostasis and MAPK pathway could be potential directions in future studies. Dolasetron, dantrolene and JNJ-31020028 can be used in clinical treatment but they have potential toxic effects. (-)Epicatechin, ginger phytochemicals and isoflavone can be tested in in vitro and in vivo for their usage as food additives for reducing the emesis. The present review summarizes and discusses some information from previous and recent prominent publications with the aim to provide some comprehensive and helpful data for understanding the mechanism of DON-induced emesis. Copyright © 2017 John Wiley & Sons, Ltd.

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Ghrelins, obestatin, nesfatin-1 and leptin levels in pregnant women with and without hyperemesis gravidarum

Cited by 24 publications

References 14 publications

Hyperemesis Gravidarum

Hyperemesis Gravidarum

The effect of Ramadan fasting on LH, FSH, oestrogen, progesterone and leptin in pregnant women

Current and prospective sights in mechanism of deoxynivalenol‐induced emesis for future scientific study and clinical treatment

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