Ghrelin Stimulates Gastric Acid Secretion and Motility in Rats

Masuda, Yutaka; Tanaka, Taisaku; Inomata, Norio; Ohnuma, Norio; Tanaka, Shoji; Itoh, Zen; Hosoda, Hiroshi; Kojima, Masayasu; Kangawa, Kenji

doi:10.1006/bbrc.2000.3568

Cited by 777 publications

(586 citation statements)

References 18 publications

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“…As dictated above, ghrelin stimulates the secretion of gastric acid [10,11] . The mechanism for the action of ghrelin on acid secretion was also demonstrated that the vagal nerve was involved in the action of ghrelin [10,11] .…”

Section: Ghrelin and Histamine Releasementioning

confidence: 88%

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Ghrelin and gastric acid secretion

Yakabi¹,

Kawashima²,

Kato³

2008

WJG

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Section: Ghrelin and Histamine Releasementioning

confidence: 88%

“…Ghrelin, and gastric acid secretion 6335 with atropine or bilateral cervical vagotomy [10] . Date and co-workers demonstrated that intracerebroventricular (ICV) administration of ghrelin induced the increase in the secretion of gastric acid and vagotomy and the pretreatment with atropine abolished the action of ghrelin [11] .…”

Section: Introductionmentioning

confidence: 99%

Ghrelin and gastric acid secretion

Yakabi¹,

Kawashima²,

Kato³

2008

WJG

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Section: A Role For Cephalic Phase Responses In Appetite and Satiety?mentioning

confidence: 99%

“…Exogenous ghrelin stimulates insulin and gastrin secretion (Lee et al, 2002), as well as secretion of gastric acid (Masuda et al, 2000), possibly via gastrin (Lee et al, 2002). Exogenous ghrelin increases gastric motility (Masuda et al, 2000). Vagotomy increases plasma ghrelin concentration (Lee et al, 2002), and abolishes the effect of exogenous ghrelin on gastric acid secretion and gastric motility (Masuda et al, 2000).…”

Section: A Role For Cephalic Phase Responses In Appetite and Satiety?mentioning

confidence: 99%

“…Exogenous ghrelin increases gastric motility (Masuda et al, 2000). Vagotomy increases plasma ghrelin concentration (Lee et al, 2002), and abolishes the effect of exogenous ghrelin on gastric acid secretion and gastric motility (Masuda et al, 2000). A cephalic ghrelin response is associated with increased fat absorption (Heath et al, 2004).…”

Section: A Role For Cephalic Phase Responses In Appetite and Satiety?mentioning

confidence: 99%

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Anticipatory physiological regulation in feeding biology: Cephalic phase responses

2008

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Anticipatory physiological regulation is an adaptive strategy that enables animals to respond faster to physiologic and metabolic challenges. The cephalic phase responses are anticipatory responses that prepare animals to digest, absorb and metabolize nutrients. They enable the sensory aspects of the food to interact with the metabolic state of the animal to influence feeding behavior. The anticipatory digestive secretions and metabolic adjustments in response to food cues are key adaptations that affect digestive and metabolic efficiency and aid in controlling the resulting elevation of metabolic fuels in the blood. Cephalic phase responses enable digestion, metabolism and appetite to be regulated in a coordinated fashion. These responses have significant effects on meal size. For example, if the cephalic phase insulin response is blocked the result is poor glucose control and smaller meals. Cephalic phase responses also are linked to motivation to feed, and may play a more direct role in regulating meal size beyond the permissive one of ameliorating negative consequences of feeding. For example, the orexigenic peptide ghrelin appears to display a cephalic phase response, rising before expected meal times. This anticipatory ghrelin response increases appetite; interestingly it also enhances fat absorption, linking appetite with digestion and metabolism.

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Roles for Ghrelin in the Regulation of Appetite and Body Weight

Cummings

Shannon²

2003

Arch Surg

254

142

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besity is a global epidemic that has proven daunting to prevent and treat. The prevalences of obesity (body mass index [BMI] Ͼ30) and morbid obesity (BMI Ͼ40) among American adults are about 30% and 5%, respectively. 1 Obesity is so strongly associated with medical comorbidities and mortality that it has begun to overtake infectious diseases as the most significant contributor to ill health worldwide. 2,3 Overweight persons are also frequently stigmatized and consequently suffer from low self-esteem. Their motivation to achieve and maintain weight loss is often Herculean. In 1 study of 47 patients who had durably lost 45 kg or more after bariatric surgery, 100% preferred to be deaf, dyslexic, diabetic, or have heart disease rather than be obese again; leg amputation and blindness were preferred by 91.5% and 89.4%, respectively. 4 The traditional treatment paradigm of diet, exercise, and medication generally achieves no more than a 5% to 10% reduction in body weight, 5,6 and recidivism after such weight loss exceeds 90% within 5 years. 7,8 This failure arises because a robust homeostatic system of body weight regulation compensates for weight loss with increased hunger and decreased energy expenditure. [9][10][11] The molecular mediators of these compensatory responses to weight loss are potential targets for antiobesity treatments. Ghrelin is a potent orexigenic (appetite-stimulating) peptide that seems to participate in the adaptive response to weight loss. Therefore, ghrelin holds promise as a target for both medical and surgical approaches to obesity.

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Ghrelin Stimulates Gastric Acid Secretion and Motility in Rats

Cited by 777 publications

References 18 publications

Ghrelin and gastric acid secretion

Ghrelin and gastric acid secretion

Anticipatory physiological regulation in feeding biology: Cephalic phase responses

Roles for Ghrelin in the Regulation of Appetite and Body Weight

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