Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract

Sakata, Ichiro; Nakamura, Kazuaki; Yamazaki, Mami; Matsubara, Maki; Hayashi, Yuijiro; Kangawa, Kenji; Sakai, Takafumi

doi:10.1016/s0196-9781(01)00633-7

Cited by 287 publications

(251 citation statements)

References 16 publications

Supporting

Mentioning

228

Contrasting

Unclassified

Order By: Relevance

“…Likewise in the human, ghrelin is synthesized and secreted from a distinct endocrine cell type found in the submucosal layer of the stomach 4 . It is similarly synthesized and secreted from other parts of the gastrointestinal tract, such as the duodenum, ileum, caecum and colon 5 . Several posttranscriptional and post-translational variants of ghrelin have been reported.…”

Section: Ghrelinmentioning

confidence: 99%

The GH–IGF-I axis and breast cancer

Laban

Bustin

Jenkins

2003

Trends in Endocrinology & Metabolism

109

View full text Add to dashboard Cite

Section: Ghrelinmentioning

confidence: 99%

The GH–IGF-I axis and breast cancer

Laban

Bustin

Jenkins

2003

Trends in Endocrinology & Metabolism

109

View full text Add to dashboard Cite

“…Similar to rats, the GCs of the porcine intestinal tract exist as two cell types, that is, roundshaped closed-type cells and triangular-shaped cells that are open into the lumen. Opened-type cells react to luminal information such as pH and nutrients, whereas closed-type cells are stimulated by hormones, neuronal stimulation or mechanical distension (Sakata et al, 2002a;Vitari et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…As an endocrine hormone, it is also present in the circulatory system and high ghrelin levels can also be detected in colostrum (Aydin et al, 2006). Ghrelin immunoreactive (IR) epithelial cells have been observed from the stomach to the colon in perinatal rodents (Sakata et al, 2002a), humans (Rindi et al, 2002) and postnatal cattle, such as sheep, pigs and horses (Hayashida et al, 2001;Vitari et al, 2012). In the gastric mucosa of rodents, the ghrelin cells (GCs) get distributed from the glandular base to the glandular neck when rat pups grow older (Sakata et al, 2002b).…”

Section: Introductionmentioning

confidence: 99%

Ghrelin in the gastrointestinal tract and blood circulation of perinatal low and normal weight piglets

Willemen

Vos

Huygelen

et al. 2013

Animal

View full text Add to dashboard Cite

Ghrelin, the 'hunger' hormone, is an endogenous growth hormone secretagogue that exerts a wide range of physiological functions. Its perinatal presence suggests that ghrelin might be involved in growth and metabolism processes during intrauterine and postnatal life. Intrauterine growth-restricted (IUGR) neonates have altered endocrine and metabolic pathways because of malnutrition during foetal development. These changes might include an altered gastrointestinal presence of ghrelin cells (GCs). As ghrelin is mainly secreted by the stomach, this altered presence might be reflected in its serum concentrations. Smallfor-gestational age (SGA) pigs appear to be a natural occurring model for IUGR children. Therefore, the first aim of this study was to investigate the presence of gastrointestinal GCs expressing active ghrelin in normal weight (NW) foetal and postnatal piglets compared with their SGA littermates using immunohistochemical analysis in combination with stereological methods. Second, total ghrelin serum concentrations of these piglets were analysed with a porcine radioactive immunoassay. In addition, the growth of the gastric pars fundica in the NW and SGA piglets was analysed stereologically. Corresponding with humans and rats, it was shown that opened-and closed-type immunoreactive GCs are distributed along the entire gastrointestinal tract of the perinatal NW and SGA piglets. However, in contrast to the rat's stomach, the porcine GCs do not disperse from the glandular base to the glandular neck during perinatal development. Furthermore, stereological analysis demonstrated that the NW neonates have a higher amount of gastric cells expressing active ghrelin compared with the SGA piglets that could result in higher milk consumption during the neonatal period. This finding is, however, not reflected in total serum ghrelin levels, which showed no difference between the NW and SGA piglets. Moreover, the stereological volume densities of the fundic layers demonstrate a similar growth pattern in the SGA and NW piglets.

show abstract

“…In both animals and man the greatest amount of ghrelin-immunoreactivity has been found in neuroendocrine cells of the gastric fundus (Date et al 2000;Tomasetto et al 2000;Ariyasu et al 2001;Gnanapavan et al 2002;Sakata et al 2002). Most gastric ghrelin cells are closed-type cells that have no continuity with the lumen (Ariyasu et al 2001), suggesting that they respond to physical stimuli from the lumen or chemical stimuli from the basolateral site, or both.…”

Section: Ghrelin Changes Following Bariatric Surgerymentioning

confidence: 99%

The Sir David Cuthbertson Medal Lecture Hunting for new pieces to the complex puzzle of obesity

Frühbeck

2006

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Disentangling the neuroendocrine systems that regulate energy homeostasis and adiposity has been a long-standing challenge in pathophysiology, with obesity being an increasingly important public health problem. Adipose tissue is no longer considered a passive bystander in bodyweight regulation. It actively secretes a large number of hormones, growth factors, enzymes, cytokines, complement factors and matrix proteins, at the same time as expressing receptors for most of these elements, which influence fuel storage, mobilisation and utilisation at both central and peripheral sites. Thus, an extensive cross talk at a local and systemic level in response to specific external stimuli or metabolic changes underpins the multifunctional characteristics of adipose tissue. In addition to the already-known adipokines, such as IL, TNFa, leptin, resistin and adiponectin, more recently attention has been devoted to 'newcomers' to the 'adipose tissue arena', which include aquaporin, caveolin, visfatin, serum amyloid A and vascular endothelial growth factor. While in vitro and in vivo experiments have provided extremely valuable information, the advances in genomics, proteomics and metabolomics are offering a level of information not previously attainable to help unlock the molecular basis of obesity. The potential and power of combining pathophysiological observations with the wealth of information provided by the human genome, knock-out models, transgenesis, DNA microarrays, RNA silencing and other emerging technologies offer a new and unprecedented view of a complex disease, conferring novel insights into old questions by identifying new pieces to the unfinished jigsaw puzzle of obesity.

show abstract

Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract

Cited by 287 publications

References 16 publications

The GH–IGF-I axis and breast cancer

The GH–IGF-I axis and breast cancer

Ghrelin in the gastrointestinal tract and blood circulation of perinatal low and normal weight piglets

The Sir David Cuthbertson Medal Lecture Hunting for new pieces to the complex puzzle of obesity

Contact Info

Product

Resources

About