Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment

Barim, Abdullah Önder; Aydın, Süleyman; Çolak, Ramis; Dağ, Ersel; Deniz, Ömer; Şahin, İ̇brahim

doi:10.1016/j.clinbiochem.2009.02.020

Cited by 86 publications

(75 citation statements)

References 34 publications

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“…Arylesterase (AE) activity, which is not affected by the presence of salt, was measured with phenyl acetate as a substrate as described earlier (10,30). The assay tube contained 750 mL 0.1 mol/L Tris-HCl (pH=8.5), 1 mmol/L CaCl 2 and 125 mL 12 mmol/L phenyl acetate and 125 mL serum (1:10 diluted with water).…”

Section: Assay Of Arylesterase Activitymentioning

confidence: 99%

“…Human ghrelin (hunger hormone) is a novel peptide hormone, which is predominantly synthesized in the stomach (10,12,13), but it is also synthesized in several other tissues including the central nervous system, kidney, heart, parathyroid glands, the small and large intestines, a-cells of the pancreatic islet (14), placenta (15), and salivary gland (16). It sti mulates growth hormone (GH) secretion and acts as a signal for the regulation of food intake, energy expenditure and fat accumulation, and body weight gain (12,17).…”

Section: Introductionmentioning

confidence: 99%

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Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Aydın¹,

Aydın²,

Croteau³

et al. 2010

Journal of Medical Biochemistry

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Kratak sadr`aj: Izlaganje cementnoj pra{ini na radnom mestu povezano je s pove}anim rizikom od promena na jetri, plu}nih bolesti i nastanka kancera. Mogu}i mehanizmi koji uzrokuju bolesti su smanjeni antioksidativni kapacitet i po vi{e na lipidna peroksidacija u plazmi. U skladu s tim, u ovoj studiji prou~avani su nivoi paraoksonaze (PON1) -arilesteraze (AE), grelina, HDL-C, LDL-C i nitrita (NOx) u serumu kod radnika izlo`enih cementnoj pra{ini. U studiji je u~e stvovalo dvadeset osam radnika u cementari i 30 dobro voljaca (kontrola), starosti 29-54 godine. Koncentra cije PON1, AE, NOx, grelina i HDL-holesterola i LDL-holesterola u serumu merene su u obe grupe. PON-1, AE, grelin i HDL-holesterol bili su ni`i kod radnika u cementari nego u kontrolnoj grupi. Nivoi nitrita i LDL-C u serumu kod radnika u cementari bili su vi{i (p<0,05) nego u kontrolnoj grupi radnika. Nije prime}ena korelacija izme|u nivoa HDL-holesterola i PON1 u serumu, kao ni izme|u HDL-holesterola i grelina. Slaba nega tivna korelacija otkrivena je izme|u grelina i NOx u serumu. Rezultati studije sna`no ukazuju na to da HDL-paraoksonaza, AE, grelin, HDL-C i visoki nivoi NOx i LDL-C verovatno igraju ulogu u bolesti koja uklju~uje oksidativna o{te}enja. Me|utim, potrebna su dalja istra`ivanja kako bi se ispitala veza izme|u izlaganja pra{ini na radnom mestu i respiratornih simptoma.

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Section: Assay Of Arylesterase Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Aydın¹,

Aydın²,

Croteau³

et al. 2010

Journal of Medical Biochemistry

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“…No differences were found in terms of PON1 activity between patients with depression and controls 17 . A diminished PON1 activity was also reported 13,18,19 . In addition, long-term AD treatment seems to increase the paraoxonase/ arylesterase levels in patients with depression 19 .…”

Section: Discussionmentioning

confidence: 94%

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Yıldız¹,

Celikel²,

Ateş³

et al. 2017

JMOOD

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Background: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.

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“…Yapılan çalışmalarda ghrelinin nöroprotektiyonda önemli koruyucu etkisi olduğu bildirilmiştir (25). Literatürde depresif hastalarda düşük (26), yüksek (27) veya değişmeyen ghrelin seviyeleri bildirilmiştir (28). Depresyon hastalarında birbirinden farklı sonuçların bulunması depresyonda ghrelinin rolü ile ilgili bazı tartışmalara neden olmaktadır.…”

Section: Bulgularunclassified

Examining Nesfatin-1 and Ghrelin Hormone in Severity of Depression

Algül¹,

Erkeç²,

Kara³

et al. 2017

Van Med J

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Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment

Cited by 86 publications

References 34 publications

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Examining Nesfatin-1 and Ghrelin Hormone in Severity of Depression

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