Ghrelin Levels in Patients with Rickets

Şen, Yaşar; Demirol, Mustafa; Demirol, Hatice; Erman, Fazilet; Kılıç, Nermin; Aydın, Süleyman; Yuca, Sevil Arı; Cimbek, Emine Ayça

doi:10.29333/ejgm/82209

Cited by 1 publication

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References 30 publications

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“…Gender and age were not related to development of rickets in studied children. This finding agreed with Tom et al , and Yasar Sen et al, who reported no relation between rachitic infants and age or sex [8, 9]. Rachitic children in our study found to have lower length values and lower mean body weight than non-rachitic children and this agrees with the study of Graff et al [11], and Rooze et al [12], but, this was not the same for Yasar Sen et al , as the difference between rachitic children and controls regarding their weight and height was insignificant [9].…”

Section: Discussionsupporting

confidence: 92%

Assessment of Preptin peptide level in the sera of rachitic children and in breast milk of their mothers

2019

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Background Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis. Research aims To measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children. Methods Thirty children with rickets and another 30 non-rachitic age and sex matched controls were subjected to detailed history, physical examination including anthropometric measurements, assessment of signs of rickets and laboratory measurement of serum vitamin D, calcium, phosphorus, alkaline phosphatase and Preptin. Mothers’ breast milk Preptin were also measured. Results Significantly lower serum Preptin ( p < 0.001) in rachitic children with a significant negative correlation between serum Preptin and alkaline phosphatase ( P < 0.0001). Lower breastmilk Preptin levels in mothers of rachitic children ( P < 0.001) with a negative correlation between breastmilk Preptin and both maternal weight and BMI( P < 0.01& P < 0.02). Mothers’ milk Preptin is positively correlated with serum Preptin and calcium in non-rachitic children(P < 0.001&0.04), but negatively correlated with their mothers’ age ( P < 0.01). Conclusion Preptin may play a role in the etiology of rickets in children. Further studies are recommended to evaluate Preptin role in treatment of rickets in children.

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