Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation

Soriano‐Guillén, Leandro; Barrios, Vicente; Campos-Barros, Ángel; Argente, Jesús

doi:10.1016/j.jpeds.2003.10.036

Cited by 191 publications

(146 citation statements)

References 40 publications

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“…Mean ghrelin concentrations of control and obese children in the latter study were higher than in our patients, which is in agreement with studies showing that ghrelin concentrations decrease with age during childhood and adolescence. 22,25 Mean age in the study of Soriano-Guillen et al 9 was 871.3 years in obese and 6.373 years in control children versus 13.971.3 years in obese and 12.271.8 years in control children in our study. In contrast to Soriano-Guillen et al, 9 who did not find a correlation between BMI and ghrelin in obese children, we demonstrated a significant negative correlation between BMI SDS and ghrelin.…”

Section: Discussioncontrasting

confidence: 45%

“…22,25 Mean age in the study of Soriano-Guillen et al 9 was 871.3 years in obese and 6.373 years in control children versus 13.971.3 years in obese and 12.271.8 years in control children in our study. In contrast to Soriano-Guillen et al, 9 who did not find a correlation between BMI and ghrelin in obese children, we demonstrated a significant negative correlation between BMI SDS and ghrelin. The negative correlation between BMI SDS and ghrelin found in our study Regulation of ghrelin in obese children K Krohn et al is in agreement with findings in obese adults.…”

Section: Discussioncontrasting

confidence: 45%

“…12 A rise in ghrelin levels after weight loss has been demonstrated earlier in adults 8 and more recently in children, who were younger than in our study. 9 In these studies, ghrelin levels remained below those of normal weight control subjects after weight loss. In our study, ghrelin levels only remained below or at the level of control children in the groups of obese children with lower estimated insulin sensitivity.…”

Section: Discussionmentioning

confidence: 65%

“…6,7 Weight loss led to an increase of plasma ghrelin in adults and children. 8,9 However, ghrelin levels remained below those of normal weight control subjects. The mechanism leading to an increase in plasma ghrelin during weight loss is still unclear.…”

Section: Introductionmentioning

confidence: 94%

“…Fasting insulin levels have been demonstrated to correlate negatively with fasting ghrelin levels in obese and normal -weight subjects in some studies, 10,11 whereas there was no relationship between insulin and ghrelin in other studies. 9 Insulin administration has been shown to decrease ghrelin levels. 12 However, this effect could not be demonstrated in other studies.…”

Section: Introductionmentioning

confidence: 99%

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Regulation of ghrelin is related to estimated insulin sensitivity in obese children

Krohn

Boczan

Otto³

et al. 2006

Int J Obes

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Objective: To investigate whether ghrelin concentrations and their changes during weight loss in obese children are associated with parameters of glucose and insulin metabolism. Design: Total plasma ghrelin, insulin and glucose were measured during oral glucose tolerance testing before and after dietinduced weight loss over 6 weeks. Setting: In-patient rehabilitation program in a pediatric hospital. Participants: Twenty-three obese children (age 10-16 years) and 11 normal weight controls (age 10-15 years). Outcome measures: Changes in ghrelin concentrations during weight loss and correlation analysis of changes in ghrelin and changes in parameters of glucose and insulin metabolism. After data collection, subgroup analysis of obese patients with high, medium and low estimated insulin sensitivity whole-body insulin sensitivity index (WBISI) was performed. Results: Weight loss increased the area under the curve (AUC) of ghrelin by 26% (Po0.001). The increase in ghrelin AUC correlated significantly with improved estimated insulin sensitivity (WBISI) (r ¼ 0.69, Po0.001). The independent predicting effect of WBISI was confirmed in multivariate analysis. In children with low WBISI, ghrelin reached the level of control values after weight loss. In children with high WBISI, ghrelin increased markedly above control levels. Conclusions: Changes in ghrelin are independently associated with changes in glucose and insulin metabolism. The increase in plasma ghrelin above control levels was limited to obese children with high WBISI.

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Section: Discussioncontrasting

confidence: 45%

Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Regulation of ghrelin is related to estimated insulin sensitivity in obese children

Krohn

Boczan

Otto³

et al. 2006

Int J Obes

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Roles of Gastrointestinal and Adipose Tissue Peptides in Childhood Obesity and Changes After Weight Loss Due to Lifestyle Intervention

Roth

Reinehr

2010

Arch Pediatr Adolesc Med

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hildhood obesity is a global epidemic and associated with an increased risk of hypertension, diabetes mellitus, and coronary heart disease, in addition to psychological disorders. Interventions such as bariatric surgery are highly invasive and lifestyle modifications are often unsuccessful because of disturbed perceptions of satiety. New signaling peptides discovered in recent years that are produced in peripheral tissues such as the gut, adipose tissue, and pancreas communicate with brain centers of energy homeostasis, such as the hypothalamus and hindbrain. This review discusses the major known gut-and adipose tissuederived hormones involved in the regulation of food intake and energy homeostasis and their serum levels in childhood obesity before and after weight loss as well as their relationship to consequences of obesity. Since most of the changes of gastrointestinal hormones and adipokines normalize in weight loss, pharmacological interventions based on these hormones will likely not solve the obesity epidemic in childhood. However, a better understanding of the pathways of body weightand food intake-regulating gut-and adipose tissue-derived hormones will help to find new strategies to treat obesity and its consequences.

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Physiology of Weight Regulation

Chaptini

Peikin

2016

Practical Gastroenterology and Hepatology Board Review Toolkit

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Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation

Cited by 191 publications

References 40 publications

Regulation of ghrelin is related to estimated insulin sensitivity in obese children

Regulation of ghrelin is related to estimated insulin sensitivity in obese children

Roles of Gastrointestinal and Adipose Tissue Peptides in Childhood Obesity and Changes After Weight Loss Due to Lifestyle Intervention

Physiology of Weight Regulation

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