Ghrelin Levels and Hunger Sensation after Laparoscopic Sleeve Gastrectomy Compared with Laparoscopic Greater Curvature Plication in Obese Patients

Dobrescu, Amadeus; Copăescu, Cătălin; Zmeu, B; Duţă, Ciprian; Bedreag, Ovidiu Horea; Stoica, Laurian; Tarţa, Cristi; Rogobete, Alexandru Florin; Lazăr, Fulger

doi:10.7754/clin.lab.2019.191012

Cited by 8 publications

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“…Present only in very small amounts in the body, no physiological role has been established yet. As a toxic element, previous studies have looked into its effects on cardiovascular function (78,79), obesity and ghrelin regulation (80,81), possible cancer occurrence (82,83), reproduction and pregnancy (84)(85)(86)(87). Rodent fetal experimentation has suggested cytotoxicity problems, progesterone disorders, microRNA expression changes, elevated oxidative stress and DNA damage (84)(85)(86).…”

Section: Discussionmentioning

confidence: 99%

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

et al. 2021

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The growth and development of the fetus is a complex phenomenon that can be influenced by several variables. High quantities of heavy metal ions in the amniotic fluid have been linked to poor health, especially in industrial, polluted and poor areas. The aim of the present study was to assess the differences in the concentration of these ions between preterm (weeks 15-37) and term pregnancies (starting at week 37). Another objective was to compare pregnancies from two cities with different industry levels. Two sample lots from two Romanian cities were analyzed. A total of 100 patients from Timisoara were compared with 60 from Petrosani, a heavy industry city in Romania. Demographic data were collected, and amniocentesis was performed on all women. Lead (Pb), copper (Cu), nickel (Ni), cadmium (Cd), arsenic (As), iron (Fe) and zinc (Zn) concentrations were assessed. Descriptive and analytical statistics were performed using the Mann-Whitney U test for non-parametric data and the Fisher's exact test for categorical data. In addition, categorical data was represented graphically. In the Timisoara cohort, the differences in heavy metal concentrations between preterm and term pregnancies were not statistically significant. In the Petrosani cohort, however, the concentrations of Zn (P=0.02606) and Cd (P=0.01512) were higher in preterm than in term pregnancies. When comparing the two cohorts as a whole, the concentration of Pb (P=0.04513), Cd (P=0.00002), As (P=0.03027) and Zn (P<0.00001) were higher in the patients from Petrosani than in those from Timisoara. Only Cu concentrations were higher in the Timisoara cohort (P<0.00001). The concentrations of Ni (P=0.78150) and Fe (P=0.44540) did not differ statistically. Thus, amniocentesis is an important diagnostic and exploratory tool in determining differences in the concentrations of elements such as heavy metal ions. Research over a longer period of time should be carried out to examine the relation between heavy metal ions concentration and possible postnatal health outcomes.

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Section: Discussionmentioning

confidence: 99%

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

et al. 2021

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“…It is known that, under normal conditions, ghrelin production in the stomach and secretion into the blood are decreased during satiety, while production increases during fasting and starvation, resulting in an increase in ghrelin concentration in the blood [ 26 ]. Conversely, blood ghrelin concentration and appetite have been found to be decreased in patients who have been administered with anticancer drugs, patients with gastric mucosal atrophy or gastrectomy [ 42 , 43 , 44 , 45 ], and in animal models of these conditions [ 22 , 46 , 47 , 48 , 49 ]. Blood ghrelin levels have been found to be reduced in mice treated with the anticancer drug cisplatin [ 46 , 47 ] and classical SSRIs [ 49 ], as well as during psychological stress [ 22 ] and cancer cachexia [ 48 ].…”

Section: Abnormal Ghrelin Secretion and Changes In Reactivitymentioning

confidence: 99%

Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease

Yamada¹

2021

IJMS

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Growth hormone secretagogue receptor 1a (GHS-R1a), which is one of the G protein-coupled receptors (GPCRs), is involved in various physiological actions such as energy consumption, growth hormone secretion promoting action, and cardiovascular protective action. The ligand was searched for as an orphan receptor for a while, but the ligand was found to be acylated ghrelin (ghrelin) discovered by Kangawa and Kojima et al. in 1999. Recently, it has also been reported that dysregulation of GHS-R1a mediates reduced feeding in various diseases. On the other hand, since the physiological effects of ghrelin have been studied exclusively in male mice, few studies have been conducted on gender differences in ghrelin reactivity. In this review, we describe (1) the characteristics of GHS-R1a, (2) the role of ghrelin in hypophagia due to stress or anticancer drugs, and (3) the gender differences in the physiological effects of GHS-R1a and the influence of stress on it.

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“…The immune system needs enough and proper nourishment to operate efficiently [ 17 , 18 , 19 ]. During an active illness, such as the SARS-CoV-2 infection, the work of the immune system boosts the need for energy even more, with increased baseline energy expenditure.…”

Section: Introductionmentioning

confidence: 99%

Calcium, Magnesium, and Zinc Supplementation during Pregnancy: The Additive Value of Micronutrients on Maternal Immune Response after SARS-CoV-2 Infection

et al. 2022

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Magnesium may contribute to the immune response during and after SARS-CoV-2 infection by acting as a cofactor for immunoglobulin production and other processes required for T and B cell activity. Considering magnesium as a recommended dietary supplement during pregnancy and the possible role of magnesium deficiency in COVID-19 and its complications, the current study sought to determine the effect of magnesium and magnesium-containing nutritional supplements on the immune response following SARS-CoV-2 infection in pregnant women, as well as to observe differences in pregnancy outcomes based on the supplements taken during pregnancy. The study followed a cross-sectional design, where patients with a history of SARS-CoV-2 infection during their pregnancy were surveyed for their preferences in nutritional supplementation and their profile compared with existing records from the institutional database. A cohort of 448 pregnant women with COVID-19 during 22 months of the pandemic was assembled, out of which 13.6% took a magnesium-only supplement, and 16.5% supplemented their diet with a combination of calcium, magnesium, and zinc. Around 60% of patients in the no-supplementation group had the SARS-CoV-2 anti-RBD lower than 500 U/mL, compared with 50% in those who took magnesium-based supplements. A quantity of magnesium >450 mg in the taken supplements determined higher levels of antibody titers after COVID-19. Low magnesium dosage (<450 mg) was an independent risk factor for a weak immune response (OR-1.25, p-value = 0.003). The observed findings suggest supplementing the nutritional intake of pregnant women with magnesium-based supplements to determine higher levels of SARS-CoV-2 anti-RBD antibodies, although causality remains unclear.

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Ghrelin Levels and Hunger Sensation after Laparoscopic Sleeve Gastrectomy Compared with Laparoscopic Greater Curvature Plication in Obese Patients

Cited by 8 publications

References 0 publications

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease

Calcium, Magnesium, and Zinc Supplementation during Pregnancy: The Additive Value of Micronutrients on Maternal Immune Response after SARS-CoV-2 Infection

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