Ghrelin is expressed in trigeminal neurons of female mice in phase with the estrous cycle

Puri, Veena; Chandrala, Syam; Puri, Sanjeev; Daniel, Carrie Gobar; Klein, Robert M.; Berman, Nancy E.J.

doi:10.1016/j.npep.2005.10.004

Cited by 21 publications

(15 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…40,41 The increased gene expression of ER in OVX rats was lowered down in the trigeminal ganglia of estrogen-replenished rats suggesting negative regulation of ER mRNA expression by estrogen. These results appear consistent with the data indicating estrogen receptor expression is negatively correlated to estrogen levels in trigeminal ganglia sensory neurons 42 , pituitary cells and cell lines 43 and central nervous system tissue. 44 …”

Section: Discussionsupporting

confidence: 92%

Effects of Estrogen on the Serotonergic System and Calcitonin Gene-Related Peptide in Trigeminal Ganglia of Rats

Aggarwal¹,

Puri

2012

ANS

Self Cite

View full text Add to dashboard Cite

BackgroundThe prevalence of migraine is 3-folds higher in females than in males, and it is intricately related to the levels of estrogen. Estrogen may regulate the expression of metabolic enzymes and receptors of serotonin and also calcitonin gene-related peptide (CGRP), which are implicated in migraine pathogenesis.PurposeTo study the effects of estrogen on the components of serotonin system and CGRP in trigeminal ganglia of ovariectomized (OVX) rats.MethodsOVX rats were administered estrogen in silastic tubes and after 48 h, serum estrogen levels were determined. Trigeminal ganglia tissues were used for RT-PCRs of tryptophan hydroxylase (TPH), monoamine oxidase (MAO), serotonin receptors (5-HT1A, 5-HT1B, 5-HT2A), estrogen receptor (ER) and CGRP. Western blots of TPH and MAO were performed.ResultsEstradiol administration to OVX rats increased TPH mRNA levels, while decreased MAO mRNA levels in trigeminal ganglia tissue. Western blot data correlate with the gene expression results. The decreased mRNA levels of serotonin receptors following ovariectomy were restored in estrogen-replenished rats. The induced gene expression of ER in OVX rats was restored following estrogen replenishment.ConclusionEstrogen levels affect the levels of serotonin metabolizing enzymes and its receptors besides CGRP levels. Since TPH and MAO levels regulate circulating and physiologically available serotonin content, the regulation of serotonin metabolizing enzymes suggest a plausible mechanism by which estrogen alleviates migraine in women.

show abstract

Section: Discussionsupporting

confidence: 92%

Effects of Estrogen on the Serotonergic System and Calcitonin Gene-Related Peptide in Trigeminal Ganglia of Rats

Aggarwal¹,

Puri

2012

ANS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Clues of a potential relationship between ghrelin and the female reproductive cycle have recently emerged. Ghrelin was up-regulated 5-fold in the central nervous system of female mice during the estrous cycle, a high-estrogen state (26). We did not find a relationship between estradiol and ghrelin in our participants, but our estradiol values were derived from a single sample instead of integrated estradiol concentrations over a longer period of time (27), which could have provided additional information.…”

Section: Discussionmentioning

confidence: 69%

Impact of Fatness, Fitness, and Ethnicity on the Relationship of Nocturnal Ghrelin to 24-Hour Luteinizing Hormone Concentrations in Adolescent Girls

Kasa-Vubu

Rosenthal

Murdock

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

“…Es el caso de estudios en roedores que demuestran la expresión de grelina en las neuronas del ganglio trigémino y cuyos receptores se localizan en una vasta zona corporal que incluye varios elementos constitutivos del aparato digestivo, explicando cambios locales comportamentales durante algunas fases del ciclo ovárico (55). En humanos, por ejemplo, hay evidencia de receptores para estrógenos en las células del ganglio espinal trigeminal, lo que propone cambios en la neuromodulación relacionada con fluctuaciones hormonales (56); incluso las concentraciones de estrógenos aparentemente modulan la expresión de péptidos específicos en el ganglio del trigémino, lo que pudiere jugar un papel importante en la génesis de migrañas y desórdenes temporomandibulares relacionados con el ciclo ovárico (57).…”

Section: Discussionunclassified

Descripción Anatómica, Fisiológica y Embriológica del Nervio Trigémino en el Marco Conceptual de la Terapia Neural, como Sustrato Frecuente de Campo Interferente

López

Salazar

Suárez

2012

nova

View full text Add to dashboard Cite

Descripción anatómica, fisiológica y embriológica del nervio trigémino en el marco conceptual de la terapia neural, como sustrato frecuente de campo interferente RESUMENLa terapia neural, como sistema médico complejo, se caracteriza por el enfoque integral del organismo cuya dinámica está enmarcada por el papel rector del sistema nervioso. Un aspecto clave de este sistema médico es que requiere una visión escrutadora general que involucra el nervio trigémino como fuente de campos interferentes.El quinto par craneano es un nervio con funciones mixtas distribuido en la región facial y craneana, que presenta interconexiones con múltiples estructuras neurales. A la luz de los postulados de Pavlov, de los diferentes hallazgos sobre plasticidad cerebral y desde el marco conceptual de la terapia neural, se busca describir, desde el punto de vista anatómico y fisiológico, la relación que tiene el trigémino con una gran variedad de estructuras neurales, lo que genera otro tipo de correlaciones clínicas y de posibilidades terapéuticas.Palabras clave: nervio trigémino, anatomía, fisiología, embriología, anastomosis, correlación, terapia neural.Anatomical, physiological and embryological description of trigeminal nerve in the conceptual framework of neural therapy, as common substrate interference field ABSTRACTNeural therapy, as a complex medical system, is characterized by the integral approach of the organism whose dynamic is framed by the leading role of the nervous system. An important aspect of this medical system is how it demands a penetrating general vision that involves the trigeminal nerve as a source of interference fields. Artículo de revisiónGloria Esperanza López 1 , Jorge Iván Salazar 2 , Édgar Osuna Suárez Descripción anatómica, fisiológica y embriológica del nervio trigémino en el marco conceptual de la terapia neural, como sustrato frecuente de campo interferente 84The fifth cranial nerve or trigeminal nerve is a nerve with mixed functions distributed in the facial and cranial region that presents interconnections with multiple neural structures. From Pavlov's principles, the different discoveries about brain plasticity, and the neural therapy conceptual framework, this paper seeks to describe, from the standpoint of anatomy and physiology, the relationship of the trigeminal nerve with a variety of neural structures, resulting in other clinical correlations and therapeutic possibilities.

show abstract

Ghrelin is expressed in trigeminal neurons of female mice in phase with the estrous cycle

Cited by 21 publications

References 71 publications

Effects of Estrogen on the Serotonergic System and Calcitonin Gene-Related Peptide in Trigeminal Ganglia of Rats

Effects of Estrogen on the Serotonergic System and Calcitonin Gene-Related Peptide in Trigeminal Ganglia of Rats

Impact of Fatness, Fitness, and Ethnicity on the Relationship of Nocturnal Ghrelin to 24-Hour Luteinizing Hormone Concentrations in Adolescent Girls

Descripción Anatómica, Fisiológica y Embriológica del Nervio Trigémino en el Marco Conceptual de la Terapia Neural, como Sustrato Frecuente de Campo Interferente

Contact Info

Product

Resources

About