Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implication
Xingli Pan,
Yuxin Gao,
Kaifu Guan
et al.
Abstract:Depression is the most common chronic mental illness and is characterized by low mood, insomnia, and affective disorders. However, the pathological mechanisms of depression remain unclear. Numerous studies have suggested that the ghrelin/GHSR system may be involved in the pathophysiologic process of depression. Ghrelin plays a dual role in the experimental animals, increasing depressed behavior and decreasing anxiety. By combining several neuropeptides and traditional neurotransmitter systems to construct neur… Show more
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