Ghrelin gene polymorphism is associated with depression, but not panic disorder

Nakashima, Keiichi; Akiyoshi, Jotaro; Hatano, Koji; Hanada, Hiroaki; Tanaka, Yoshihiro; Tsuru, Jusen; Matsushita, Hirotaka; Kodama, Kensuke; Isogawa, Koichi

doi:10.1097/ypg.0b013e328306c979

Cited by 52 publications

(35 citation statements)

References 7 publications

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“…Surprisingly little is known about the effects of chronic ghrelin exposure on these behaviours, forming a key aim of the present study. Even though, genetic and pharmacological studies suggest that ghrelin may be of clinical relevance for psychiatric conditions like mood disorders in man , Nakashima et al, 2008 some contradictory data have been published (Emul et al, 2007, Kluge et al, 2009). …”

Section: 2mentioning

confidence: 99%

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

et al. 2011

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Section: 2mentioning

confidence: 99%

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

et al. 2011

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“…It appears that the mechanism in which these two hormones affect mood or are affected by mood could be further enlightened if a limbic areas and the hypothalamus create a circuit that connects emotional states and eating behavior. Moreover, Nakashima et al [71] , found an association between a gene polymorphism and depression. Different studies in animals yielded contrasting findings.…”

Section: Ref Findingsmentioning

confidence: 99%

Mood disorders: A potential link between ghrelin and leptin on human body?

Zarouna

Wozniak

2015

WJEM

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Leptin and ghrelin are two hormones associated with multiple physiological functions, especially energy balance. Leptin is an adipocyte-secreted hormone discovered in 1950 and ghrelin which was found in 1999, is a peptide hormone produced and secreted in the stomach. A number of previous studies showed that these hormones could be associated with different types of mood disorders. The results of previous studies, nevertheless, are confounded by diverse sample selection and different methodologies. A search for related articles in the PubMed database was attempted. The search covered studies, reports, reviews and editorials published in the last ten years. Older references served as auxiliary sources for comparison purposes. However, due to the different results of the studies, there is a need for more investigation in order to establish the exact biochemical mechanisms that are responsible for these diseases and ghrelin's and leptin's effects on mood. Core tip: Mood disorders are affecting a major amount of the world population. Considering the multiple factors that are contributing in the development of mood disorders, this review emphasizes on the role of leptin and ghrelin hormones. These two hormones have a key role in energy balance but they also have an effect on other physiological functions too, therefore we emphasize on the recent findings which raise a potential link between the hormones and the disorders of mood.

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“…One study has reported that the levels of acylated and des-acylated ghrelin are lower in depressive patients before and after citalopram treatment than in the control group (OlszaneckaGlinianowicz et al, 2010). Other studies have shown no significant difference in patients with major depression (Asakawa et al, 2001a;Nakashima et al, 2008;Ogaya et al, 2011). Despite of these controversial findings, emerging evidences suggest that ghrelin plays an important role in depression.…”

Section: Ghrelin and Memory Depression And Anxietymentioning

confidence: 93%

Ghrelin, a Gastric Hormone with Diverse Functions

Li¹,

Luo²,

Li³

et al. 2012

Chemical Biology

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Ghrelin gene polymorphism is associated with depression, but not panic disorder

Cited by 52 publications

References 7 publications

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

Mood disorders: A potential link between ghrelin and leptin on human body?

Ghrelin, a Gastric Hormone with Diverse Functions

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