Ghrelin gene polymorphism as a genetic biomarker for prediction of therapy induced clearance in Egyptian chronic HCV patients

Hamdy, Marwa; Kassim, Samar K.; Khairy, Eman; Maher, Mohamed; Mansour, Khaled A; Albreedy, Ashraf M

doi:10.1016/j.gene.2018.01.077

Cited by 8 publications

(7 citation statements)

References 39 publications

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“…The protein encoded by the ghrelin gene is the ligand for the growth hormone secretagogue receptor, which mainly regulates the concentration of growth hormone in the body and affects some of the body’s functions through affecting the release of growth hormone, such as regulating growth and development, affecting sugar, lipid and protein metabolism, and relaxing the cardiovascular system [ 16 , 17 ]. It has been proved that the ghrelin gene polymorphisms can affect the occurrence and susceptibility to a variety of diseases, such as polycystic ovary syndrome [ 18 ], chronic hepatitis C [ 19 ], and type 2 diabetes mellitus [ 20 ]. In cerebral infarction patients, the effects of ghrelin gene polymorphisms have not been studied yet.…”

Section: Discussionmentioning

confidence: 99%

Association Between Ghrelin Gene Polymorphism and Cerebral Infarction

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Association Between Ghrelin Gene Polymorphism and Cerebral Infarction

et al. 2020

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“…Data on ghrelin concentration in CHC and chronic hepatitis B (CHB) are limited [ 164 , 165 , 166 ], including those for patients on antiviral treatment [ 167 , 168 ]. Plasma AG concentrations were significantly lower in relation to the severity of liver disease in both the HBV- and HCV-infected patients.…”

Section: The Effects Of Ghrelin System On the Hepatic Inflammationmentioning

confidence: 99%

“…Attempts have been made to study genetic variants in GHRL in various CLDs in humans in the context of their prognostic significance [ 42 , 165 , 166 , 175 ]. Moreno et al, studying European patients with CHC, observed that those with the -994T and -604A haplotype are more prone to severe liver fibrosis [ 42 ].…”

Section: The Effects Of Ghrelin System On the Hepatic Inflammationmentioning

confidence: 99%

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Role of the Ghrelin System in Colitis and Hepatitis as Risk Factors for Inflammatory-Related Cancers

Kasprzak

Adamek

2022

IJMS

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It is not known exactly what leads to the development of colorectal cancer (CRC) and hepatocellular carcinoma (HCC), but there are specific risk factors that increase the probability of their occurrence. The unclear pathogenesis, too-late diagnosis, poor prognosis as a result of high recurrence and metastasis rates, and repeatedly ineffective therapy of both cancers continue to challenge both basic science and practical medicine. The ghrelin system, which is comprised of ghrelin and alternative peptides (e.g., obestatin), growth hormone secretagogue receptors (GHS-Rs), and ghrelin-O-acyl-transferase (GOAT), plays an important role in the physiology and pathology of the gastrointestinal (GI) tract. It promotes various physiological effects, including energy metabolism and amelioration of inflammation. The ghrelin system plays a role in the pathogenesis of inflammatory bowel diseases (IBDs), which are well known risk factors for the development of CRC, as well as inflammatory liver diseases which can trigger the development of HCC. Colitis-associated cancer serves as a prototype of inflammation-associated cancers. Little is known about the role of the ghrelin system in the mechanisms of transformation of chronic inflammation to low- and high-grade dysplasia, and, finally, to CRC. HCC is also associated with chronic inflammation and fibrosis arising from different etiologies, including alcoholic and nonalcoholic fatty liver diseases (NAFLD), and/or hepatitis B (HBV) and hepatitis C virus (HCV) infections. However, the exact role of ghrelin in the progression of the chronic inflammatory lesions into HCC is still unknown. The aim of this review is to summarize findings on the role of the ghrelin system in inflammatory bowel and liver diseases in order to better understand the impact of this system on the development of inflammatory-related cancers, namely CRC and HCC.

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“…Gene polymorphism describes individual variations in alleles or genotypes at the same locus in the population, which can change the expression of a gene and influence the occurrence of disease or increase/decrease the population's susceptibility to some diseases [20]. Several polymorphisms of ghrelin and its receptor have been described, particularly in diabetes [21,22], obesity [23], metabolic disorders [24,25], cardiovascular disease [26], hepatitis [27], anorexia-cachexia [28,29], and alcoholism [30,31]. The ghrelin polymorphisms most studied to date are located in the promoter and coding regions of the gene; some of them have implications for gene activity [21].…”

Section: Introductionmentioning

confidence: 99%

SNPs-Panel Polymorphism Variations in GHRL and GHSR Genes Are Not Associated with Prostate Cancer

Merabet,

Ramoz,

Boulmaiz

et al. 2023

Biomedicines

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Prostate cancer (PCa) is a major public health problem worldwide. Recent studies have suggested that ghrelin and its receptor could be involved in the susceptibility to several cancers such as PCa, leading to their use as an important predictive way for the clinical progression and prognosis of cancer. However, conflicting results of single nucleotide polymorphisms (SNPs) with ghrelin (GHRL) and its receptor (GHSR) genes were demonstrated in different studies. Thus, the present case–control study was undertaken to investigate the association of GHRL and GHSR polymorphisms with the susceptibility to sporadic PCa. A cohort of 120 PCa patients and 95 healthy subjects were enrolled in this study. Genotyping of six SNPs was performed: three tag SNPs in GHRL (rs696217, rs4684677, rs3491141) and three tag SNPs in the GHSR (rs2922126, rs572169, rs2948694) using TaqMan. The allele and genotype distribution, as well as haplotypes frequencies and linked disequilibrium (LD), were established. Multifactor dimensionality reduction (MDR) analysis was used to study gene–gene interactions between the six SNPs. Our results showed no significant association of the target polymorphisms with PCa (p > 0.05). Nevertheless, SNPs are often just markers that help identify or delimit specific genomic regions that may harbour functional variants rather than the variants causing the disease. Furthermore, we found that one GHSR rs2922126, namely the TT genotype, was significantly more frequent in PCa patients than in controls (p = 0.040). These data suggest that this genotype could be a PCa susceptibility genotype. MDR analyses revealed that the rs2922126 and rs572169 combination was the best model, with 81.08% accuracy (p = 0.0001) for predicting susceptibility to PCa. The results also showed a precision of 98.1% (p < 0.0001) and a PR-AUC of 1.00. Our findings provide new insights into the influence of GHRL and GHSR polymorphisms and significant evidence for gene–gene interactions in PCa susceptibility, and they may guide clinical decision-making to prevent overtreatment and enhance patients’ quality of life.

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Ghrelin gene polymorphism as a genetic biomarker for prediction of therapy induced clearance in Egyptian chronic HCV patients

Cited by 8 publications

References 39 publications

Association Between Ghrelin Gene Polymorphism and Cerebral Infarction

Association Between Ghrelin Gene Polymorphism and Cerebral Infarction

Role of the Ghrelin System in Colitis and Hepatitis as Risk Factors for Inflammatory-Related Cancers

SNPs-Panel Polymorphism Variations in GHRL and GHSR Genes Are Not Associated with Prostate Cancer

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