Ghrelin effects expression of several genes associated with depression-like behavior

Poretti, María Belén; Rask‐Andersen, Mathias; Kumar, Praveen; Barioglio, Susana Rubiales de; Cúneo, Marta Fiol de; Schiöth, Helgi B.; Carlini, Valeria Paola

doi:10.1016/j.pnpbp.2014.09.012

Cited by 25 publications

(16 citation statements)

References 67 publications

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“…Chronic icv ghrelin treatment increases depression and anxiety related behaviors in male rats (Hansson et al, 2011), and the PVN appears to be an area particularly sensitive to the anxiogenic effects of ghrelin (Currie et al, 2012), possibly mediated through changes in AVP (Poretti et al, 2015). Serum ghrelin levels in humans are elevated in patients with major depression, and responders to treatments for depression and panic disorder have lower ghrelin levels than non-responders (Ishitobi et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Early life social stress induced changes in depression and anxiety associated neural pathways which are correlated with impaired maternal care

et al. 2015

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Exposures to various types of early life stress can be robust predictors of the development of psychiatric disorders, including depression and anxiety. The objective of the current study was to investigate the roles of the translationally relevant targets of central vasopressin, oxytocin, ghrelin, orexin, glucocorticoid, and the brain-derived neurotrophic factor (BDNF) pathway in an early chronic social stress (ECSS )based rodent model of postpartum depression and anxiety. The present study reports novel changes in gene expression and extracellular signal related kinase (ERK) protein levels in the brains of ECSS exposed rat dams that display previously reported depressed maternal care and increased maternal anxiety. Decreases in oxytocin, orexin, and ERK proteins, increases in ghrelin receptor, glucocorticoid and mineralocorticoid receptor mRNA levels, and bidirectional changes in vasopressin underscore related work on the adverse long-term effects of early life stress on neural activity and plasticity, maternal behavior, responses to stress, and depression and anxiety-related behavior. The differences in gene and protein expression and robust correlations between expression and maternal care and anxiety support increased focus on these targets in animal and clinical studies of the adverse effects of early life stress, especially those focusing on depression and anxiety in mothers and the transgenerational effects of these disorders on offspring.

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Section: Discussionmentioning

confidence: 99%

Early life social stress induced changes in depression and anxiety associated neural pathways which are correlated with impaired maternal care

et al. 2015

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“…Due to the wide spread expression of GHSR1, ghrelin has been shown to play a role, in energy homeostasis, eating behavior, sleeping behavior ( 73 ), cognition, reward mechanisms ( 74 ), and mood ( 75 ), all of which can be altered in MDD. As with leptin, a body of work now supports the role of ghrelin in regulating mood, with close links to depression ( 73 , 76 ). Ghrelin has a role in response to acute stress in both animals and humans, with acute stress resulting in elevated ghrelin levels and activation of the hypothalamus-pituitary axis (HPA) ( 77 , 78 ).…”

Section: Ghrelin As a Potential Biomarker Of Gut-brain Interactions Imentioning

confidence: 99%

Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder

Horne

Foster

2018

Front. Psychiatry

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Advances in understanding the role of the microbiome in physical and mental health are at the forefront of medical research and hold potential to have a direct impact on precision medicine approaches. In the past 7 years, we have studied the role of microbiota-brain communication on behavior in mouse models using germ-free mice, mice exposed to antibiotics, and healthy specific pathogen free mice. Through our work and that of others, we have seen an amazing increase in our knowledge of how bacteria signal to the brain and the implications this has for psychiatry. Gut microbiota composition and function are influenced both by genetics, age, sex, diet, life experiences, and many other factors of psychiatric and bodily disorders and thus may act as potential biomarkers of the gut-brain axis that could be used in psychiatry and co-morbid conditions. There is a particular need in major depressive disorder and other mental illness to identify biomarkers that can stratify patients into more homogeneous groups to provide better treatment and for development of new therapeutic approaches. Peripheral outcome measures of host-microbe bidirectional communication have significant translational value as biomarkers. Enabling stratification of clinical populations, based on individual biological differences, to predict treatment response to pharmacological and non-pharmacological interventions. Here we consider the links between co-morbid metabolic syndrome and depression, focusing on biomarkers including leptin and ghrelin in combination with assessing gut microbiota composition, as a potential tool to help identify individual differences in depressed population.

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“…Moreover, it has also been reported that antidepressant treatment can alleviate depressive symptoms by inhibiting their expression (Wu et al, 2007 ; Dagyte et al, 2011 ; Müller et al, 2011 ). Given the effect of synaptic vesicle proteins on the pathogenesis of depression and their interaction with anorexigenic or orexigenic neurotransmitters (Fried et al, 1995 ; Papke et al, 2012 ; Poretti et al, 2015 ), one of the aims of the present study is to investigate the potential effect of nesfatin-1 on the expression of synaptotagmin I and synapsin I in the hypothalamus.…”

Section: Introductionmentioning

confidence: 99%

Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins

Qin

et al. 2015

Front. Neurosci.

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Depression is a multicausal disorder and has been associated with metabolism regulation and immuno-inflammatory reaction. The anorectic molecule nesfatin-1 has recently been characterized as a potential mood regulator, but its precise effect on depression and the possible mechanisms remain unknown, especially when given peripherally. In the present study, nesfatin-1 was intraperitoneally injected to the rats and the depression-like behavior and activity of the hypothalamic-pituitary-adrenal (HPA) axis were evaluated. The plasma concentrations of nesfatin-1, interleukin 6 (IL-6), and C-reactive protein (CRP); and the hypothalamic expression levels of nesfatin-1, synapsin I, and synaptotagmin I mRNA were evaluated in nesfatin-1 chronically treated rats. The results showed that both acute and chronic administration of nesfatin-1 increased immobility in the forced swimming test (FST), and resulted in the hyperactivity of HPA axis, as indicated by the increase of plasma corticosterone concentration and hypothalamic expression of corticotropin-releasing hormone (CRH) mRNA. Moreover, after chronic nesfatin-1 administration, the rats exhibited decreased activity and exploratory behavior in the open field test (OFT) and increased mRNA expression of synapsin I and synaptotagmin I in the hypothalamus. Furthermore, chronic administration of nesfatin-1 elevated plasma concentrations of IL-6 and CRP, which were positively correlated with despair behavior, plasma corticosterone level, and the hypothalamic mRNA expression of synapsin I and synaptotagmin I. These results indicated that exogenous nesfatin-1 could induce the immune-inflammatory activation, which might be a central hug linking the depression-like behavior and the imbalanced mRNA expression of synaptic vesicle proteins in the hypothalamus.

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Ghrelin effects expression of several genes associated with depression-like behavior

Cited by 25 publications

References 67 publications

Early life social stress induced changes in depression and anxiety associated neural pathways which are correlated with impaired maternal care

Early life social stress induced changes in depression and anxiety associated neural pathways which are correlated with impaired maternal care

Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder

Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins

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