Ghrelin and obestatin plasma levels and ghrelin/obestatin prepropeptide gene polymorphisms in small for gestational age infants

Zhang, Shulian; Zhai, Guanpeng; Zhang, Jinping; Zhou, Jianguo; Chen, Chao

doi:10.1177/0300060514533525

Cited by 8 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As expected, in our study the GHRL rs696217 T allele showed a statistically significant association with waist circumference and hip circumference level in all subjects. The GHRL Arg51Gln [rs34911341 (C>T)] was associated with hypertension in Caucasian subjects [35], on the other hand, the 51Gln marker has been found to have a protective factor against the development of T2DM [24,36]. The Arg51 residue is a site for proteolytic cleavage to synthesis ghrelin, and its substitution to the 51Gln variant leads to lower ghrelin plasma levels, resulting in less abundant synthesizing of the preproghrelin peptide [37].…”

Section: Discussionmentioning

confidence: 99%

“…The GHRL Leu72Met variant and obesity-related phenotype and metabolic diseases vary according to different populations. Surprisingly, there is no study to show any association of the GHRL c.152C>T (p.Arg51 Gln) (rs34911341) variant and being obese in the literature [ 24 ]. Detection of gene variants and modifiers that might regulate the gene expression are crucial.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dual effect of the GHRL gene variant in the molecular pathogenesis of obesity

Becer

Ergoren

2021

Balkan Journal of Medical Genetics

View full text Add to dashboard Cite

Obesity is as a global health problem due to its interaction with complex chronic disorders such as cardiovascular disorders, type 2 diabetes mellitus (T2DM) and cancer. Despite the fact that pathogenesis of obesity is not yet clearly understood, it is associated with a combination of psychological, environmental and various genetic factors. Here, employing a case-control design, we aimed to examine the effects of the GHRL c.152C>T (p.Arg51Gln) (rs34911341) and c.214G>T (p.Leu72Met) (rs696217) markers on susceptibility to obesity in a Turkish-Cypriot population, as well as to evaluate whether these markers affect biochemical parameters and show their putative functional consequences. This study involved 211 Turkish-Cypriot subjects (106 obese and 95 non obese). Genotyping for the GHRL gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Our results indicate that the GHRL Leu72Met polymorphism was found to be significantly higher in obese patients, with respect to genotypic (p = 0.0012) and allelic (p = 0.0005) frequencies. Strikingly, the rs696217 GT genotype (heterozygous) had significantly lower serum high-density lipoprotein cholesterol (HDL-C) (p = 0.015) than GG (wild type) genotypes. Overall, Leu72Met susceptibility variant may be considered as risk and crucial marker for both obesity and cholesterol metabolism in the community of Turkish-Cypriots. Thus, the dual effect of the GHRL gene Leu72Met variant may be used for clinical diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dual effect of the GHRL gene variant in the molecular pathogenesis of obesity

Becer

Ergoren

2021

Balkan Journal of Medical Genetics

View full text Add to dashboard Cite

show abstract

“…These findings are consistent with those of previous studies that have shown an OB-induced reduction in MDA levels in different experimental models. 15,19 SODs are enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. High SOD levels in the immature and newborn's intestines are known to exert a protective effect against intestinal ischemia and reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 Studies associated with OB in newborns are related only to plasma OB levels. 18,19 In these studies, the OB levels in newborns with different birth weights according to gestational age were investigated. It was reported that small for gestational age newborns have higher plasma OB levels than large for gestational age newborns, and it has been suggested that OB levels may be involved in growth and development in newborns.…”

mentioning

confidence: 99%

Obestatin Reduces Intestinal Damage in Experimental Necrotizing Enterocolitis in Newborn Rats

et al. 2018

View full text Add to dashboard Cite

Objective To investigate the effect of pretreatment with obestatin (OB), an endogenous hormone also found in mother's milk, in experimental necrotizing enterocolitis (NEC). Study Design Pups were randomized into four groups: control, OB-control, NEC, and OB-NEC. NEC was induced by asphyxia and hypothermia in the NEC and OB-NEC groups. OB was administered to the OB-control and OB-NEC groups. Macroscopic scoring of the intestinal tract was evaluated and tissue samples were obtained for histopathological and biochemical examination on the fourth day. Results OB improved the macroscopic appearance of the gut and the clinical score during the experiment (p < 0.05). The rate of occurrence of NEC in the OB-NEC group was lower than the NEC group (p = 0.001). OB prevented necrosis and reduced the number of apoptotic cells in the OB-NEC group compared with the NEC group (p = 0.006). Furthermore, interleukin-6 and malondialdehyde levels in the OB-NEC group were lower than the NEC group (p < 0.05). Conclusion OB reduced intestinal damage and prevented necrosis through anti-inflammatory and antiapoptotic effects in experimental NEC. This effect of OB should be confirmed in clinical studies. Furthermore, future research should investigate whether OB plays a role in NEC pathogenesis or NEC is associated with OB levels in the serum and in breast milk.

show abstract

“…However, some studies have different findings. That is, no difference was observed in the serum ghrelin levels between full-term and preterm infants and between AGA and large for gestational age (LGA) infants ( 19 , 41 , 42 ). Moreover, SGA neonates have lower cord blood ghrelin levels ( 43 ).…”

Section: Role Of Ghrelin In Fetal Developmentmentioning

confidence: 99%

Role of ghrelin in promoting catch-up growth and maintaining metabolic homeostasis in small-for-gestational-age infants

Zhang,

Liu,

Gao

et al. 2024

Front. Pediatr.

View full text Add to dashboard Cite

Small-for-gestational age (SGA) has been a great concern in the perinatal period as it leads to adverse perinatal outcomes and increased neonatal morbidity and mortality, has an impact on long-term health outcomes, and increases the risk of metabolic disorders, cardiovascular, and endocrine diseases in adulthood. As an endogenous ligand of the growth hormone secretagotor (GHS-R), ghrelin may play an important role in regulating growth and energy metabolic homeostasis from fetal to adult life. We reviewed the role of ghrelin in catch-up growth and energy metabolism of SGA in recent years. In addition to promoting SGA catch-up growth, ghrelin may also participate in SGA energy metabolism and maintain metabolic homeostasis. The causes of small gestational age infants are very complex and may be related to a variety of metabolic pathway disorders. The related signaling pathways regulated by ghrelin may help to identify high-risk groups of SGA metabolic disorders and formulate targeted interventions to prevent the occurrence of adult dwarfism, insulin resistance-related metabolic syndrome and other diseases.

show abstract

Ghrelin and obestatin plasma levels and ghrelin/obestatin prepropeptide gene polymorphisms in small for gestational age infants

Cited by 8 publications

References 26 publications

Dual effect of the GHRL gene variant in the molecular pathogenesis of obesity

Dual effect of the GHRL gene variant in the molecular pathogenesis of obesity

Obestatin Reduces Intestinal Damage in Experimental Necrotizing Enterocolitis in Newborn Rats

Role of ghrelin in promoting catch-up growth and maintaining metabolic homeostasis in small-for-gestational-age infants

Contact Info

Product

Resources

About